HI Stewie, good morning to you!
I have hundreds of papers and unpublished studies gathered up to do my PPT presentation at A4M and A5M when I have the second round of hippocampal scans and the 5th round of N-P testing on my Azlheimer's patients. Yes,what you are reading out there is that 3/3 is average risk but new data (I'm sorry I have it somewhere in my list) shows it is slight increase.Sorry if I sent old data-I haven't really sorted through my "pile" adequately.....
IMHO the effect of the DNA is less than the effect of excitotoxins like artificial sweetners,diacetyl or MSG...or synthetic estrogens...or HEAD TRAUMA. There are even papers suggesting BB puts guys at increased risk-haven't read these yet so don't know the mechanism-these are all studies in progess.....
Re epigenetics as you well know we are CONSTANTLY undergoing epigenetic manipulation with our diets, for example. For those who are getting lost with your resident genius Stewie and I here chatting here is what this means. What this means in simple terms is say you have genes for diabetes. When you eat clean you "down-regulate" those genes. When you eat a HAPPY MEAL you "up-regulate" those genes. Get it?
My AD research involves a lot of epigenetic research....all the factors and there are a LOT that go into making someone "get" AD which starts happening 25 years PRIOR to clinical symptoms with detectable amyloid which is why I beat the TAKE A GOOD CURCUMINOID drum so much -for inflammation yes,but it also dissolves amyloid. Does it prevent AD? We do not know as the amyloid is chicken-egg situation.
We DO know high cortisols which ALL BB"s have due to intense physical stress on the body DOES up the chances of AD and IMHO I believe this will be one of the main "mechanisms" elucidated as the BB-AD connection.
And Stewie,you have good docs but do ANY of them talk about cortisol and it's role in placquing-if you see a prior post you will see I listed cortisol levels and they play quite a role in all diseases including CAD and this is the one factor I've noticed even good preventive cardiologists are not addressing.
OK enough for one post and I agree-
Good conversation
.gif "IP Gear")
