Selank

[Press]

definitely be adding this to my next order. thanx JJ

 

[johnjuanb1]

Selanks’ method of action is entirely unique of most other nootropics. It is thought to modulate the concentration of monoamine neurotransmitters. This may have incredible benefits for cognition. Another recognized benefit is its alleged effects on brain-derived neurotropic factor (BDNF)

 

[johnjuanb1]

Selank is able to influence the release of both the neurotransmitter Dopamine and Serotonin.

 

[bootdoc]

Selank- positive response

75 kg male
67 in

250-500 mcg daily
really calms the model down in the virtual reality model

 

[johnjuanb1]

Selank considered to be immunomodulatory, or capable of improving and changing the immune system for the better.

 

[johnjuanb1]

[Compensatory and antiamnestic effects of heptapeptide Selank in monkeys].

Authors
[No authors listed]
Journal
Zh Evol Biokhim Fiziol. 2008 May-Jun;44(3):284-90. Article in Russian.

Affiliation
Abstract
The work presents results of study of role of heptapeptide Selank--an anxiolytic from group of biologically active peptides--in compensation of disturbed psychic and homeostatic functions in monkeys. New data have been obtained which indicate that an intranasal administration of Selank produces long-term changes of the monkeys' behavior disturbed during neurosis: elimination of fear and aggression and an increase of orientational-explorative activity as well as facilitation of handling reactions and communicational relations. It has been established that on the background of the Selank there occurs a long compensation of disturbed psychic functions (processes of memory) and of homeostatic parameters. It has been shown that unlike the earlier studied neurohormones (thyroliberin and ACTH4-10), the antistressor Selank effects do not depend on the type of neurotic disturbances and have long-term compensatory character. Comparison of the data obtained on monkeys with results of similar studies on the more low-organized mammals (rodents) allow suggesting that the new peptide preparation Selank is a promising agent for correction of various psychoemotional disturbances (alarm- and depression-like disorders).

PMID 18727417 [PubMed - indexed for MEDLINE]

 

[johnjuanb1]

[Experimental optimization of learning and memory processes by selank].

AuthorsSemenova TP, et al. Show all Journal
Eksp Klin Farmakol. 2010 Aug;73(8):2-5. Article in Russian.

Affiliation
Abstract
The effect of selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), which is a synthetic derivative of the endogenous tetrapeptide tuftsin (stable with respect to tissue peptidases), on the learning and memory processes and metabolism of serotonin (5-HT) have been experimentally studied on Wistar rats. The animals were trained with food reward in 30 trials per day. Selank (300 microg/kg) or saline were injected after the 10th trial. Elaboration of conditioned reflex with food reward was continued 30 min later. Retention was tested 24 h, 7 and 30 days after treatment. A single injection of selank activated the metabolism of 5-HT in the hypothalamus and caudal brain stem for 30 min to 2 h. It was established that selank induces an increase in memory trace stability during 30 days. These findings provide direct evidence that selank, when injected during consolidation phase, can enhance memory storage processes. Nootrope activity of the selank is probably caused by its obvious effect on the level of serotonin and its metabolite in the brain.

 

[johnjuanb1]

I interpret this study to be one of those old studies where they give a rat certain choices and if the rat makes the incorrect choice he is punished. This is what they mean by "conditined active avoidance reflex", if I'm not mistaken. This study shows that rats with below normal learning abilities improve rapidly post selank administration.


The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats.

AuthorsKozlovskii II, et al. Show all Journal
Neurosci Behav Physiol. 2003 Sep;33(7):639-43.

Affiliation
Abstract
The actions of the synthetic heptapeptide preparation Selank on learning and memory processes in rats with initially low levels of learning ability were compared with those in normal rats, using a method based on acquisition of a conditioned active avoidance reflex, with repeated administration of peptide 15 min before the start of training sessions for four days. The effects of Selank (300 microg/kg) were compared with the effects of the nootrope piracetam (400 mg/kg). These experiments showed that Selank significantly activated the learning process in rats with initially poor learning ability, with effects apparent after first dose on training day 1. The effect progressively increased on repeated administration of Selank: the total number of correct solutions increased and the number of errors decreased (p < 0.05). The maximum optimizing activity of Selank on learning in normal rats was seen on day 3 of repeated administration and training, i.e., after formation of the initial consolidation phase. The dynamic features of the development of the activating action of Selank and piracetam were described. Comparison of the results obtained here with data on the anti-anxiety actions of Selank suggested potential for its use in optimizing mnestic functions in conditions of elevated emotional tension.

PMID 14552529 [PubMed - indexed for MEDLINE]

 

[johnjuanb1]

[Effects of the new peptide anxiolytic drug selank on the cardiovascular system functioning and respiration in cats].

AuthorsGan'shina TS, et al. Show all Journal
Eksp Klin Farmakol. 2005 Jul-Aug;68(4):33-5. Article in Russian.

Affiliation
Abstract
The effects of the new heptapeptide anxiolytic drug selank (300 mg/kg, i.v.) on the arterial pressure (AP), cerebral blood flow, heart rhythm, respiration, and the AP depression induced by acetylcholine injections was recorded in narcotized male cats. Selank produced a 32 +/- 4.3% decrease in the AP for the first 1-3 min after injection. The drug also induced a 24 +/- 2.8% increase in the cerebral blood flow for the first 5 - 10 min upon injection and then the blood flow was gradually restored on the initial level. The heart rate and the respiratory rate were not affected by the drug injections. Nor did selank influence the AP depression in response to the acetylcholine introduction.

PMID 16193654 [PubMed - indexed for MEDLINE]

 

[johnjuanb1]

It was posted on another forum that Selank is helping remove withdrawal symptoms from a chronic pain suffer who is prescribed opiates. That's very interesting as anyone who has ever withdrawn from opiates knows it's pure hell!!!

 

[johnjuanb1]

[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].

AuthorsZozulia AA, et al. Show all Journal
Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48. Article in Russian.

Affiliation
Abstract
Sixty-two patients with generalized anxiety disorder (GAD) and neurasthenia were studied. The effect of selank (30 patients) was compared to that of medazepam (32 patients). Patient's state was assessed with psychometric scales (Hamilton, Zung, CGI). Enkephalin activity in the blood serum was measured as well. The anxiolytic effects of both drugs were similar but selank had also antiasthenic and psychostimulant effects. The clinical-biological study revealed that patients with GAD and neurasthenia had the decreased level of tau(1/2) leu-enkephalin which was correlated with disease duration, severity of symptoms related to anxiety and asthenia and autonomic disorders. The increase of this parameter and stronger positive correlations with anxiety level were observed during the treatment with selank mostly in patients with GAD.

 

[johnjuanb1]

Selank-induced normalizing effects on the integrative brain activity and biogenic amine level disorders due to antenatal hypoxia.

AuthorsSemenova TP, et al. Show all Journal
Ross Fiziol Zh Im I M Sechenova. 2006 Nov;92(11):1332-8. Article in Russian.

Affiliation
Abstract
The effects of Selank synthetic analog of Tuftsin, representing the heptapeptide forming Thr-Lys-Pro-Arg-Pro-Gly-Pro, on behavior and serotonin/noradrenalin concentrations in brain were investigated in adult rats exposed to hypoxia during 14-16 days of gestation. It was revealed that injection of Selank (300 mkg/kg, i/p) increased 2--3-fold (p < 0.01) the sensory attention, facilitated 1.5-fold the learning capacity (p < 0.01), normalized exploratory activity in the open field and hole board, and recovered the balance of serotonergic and noradrenergic brain system activity. The data obtained demonstrate the possibility of Selank to compensate for long-lasting negative effects of antenatal hypoxia on integrative brain activity and brain monoamine level.

PMID 17385425 [PubMed - indexed for MEDLINE]

 

[Press]

great info! thanx

JJ which peptide do you think is best for anxiety/lowering heart rate?

 

[Elvia1023]

Out of the 3 I had in mine Selank is number one after more research. I was basically just after something that helped with anxiety. Everyone seems to really find benefits from it. It sounds like it would be great for me. Budget is limited so I had to take it off my shipping cart but I will try it out soon.

It was a choice between 2nd vial of LR3 or selank... had to go with the muscle growth

 

[Elvia1023]

great info! thanx

JJ which peptide do you think is best for anxiety/lowering heart rate?

Not JJ but from my research I would definitely say selank. Although it shouldn't effect heart rate. I assume you just mean an elevated heart rate due to anxiety? You don't have a high resting heart rate do you? So if you stop the anxiety you stop the times of an elevated heart rate.

I have seen various studies on rodents and cats etc relating to cardiovascular effects and heart rate was never effected. Although as you know humans are different.

[Effects of the new peptide anxiolytic drug selank on the cardiovascular system functioning and respiration in cats].

Gan'shina TS, Kozlovskiĭ II.

Abstract

The effects of the new heptapeptide anxiolytic drug selank (300 mg/kg, i.v.) on the arterial pressure (AP), cerebral blood flow, heart rhythm, respiration, and the AP depression induced by acetylcholine injections was recorded in narcotized male cats. Selank produced a 32 +/- 4.3% decrease in the AP for the first 1-3 min after injection. The drug also induced a 24 +/- 2.8% increase in the cerebral blood flow for the first 5 - 10 min upon injection and then the blood flow was gradually restored on the initial level. The heart rate and the respiratory rate were not affected by the drug injections. Nor did selank influence the AP depression in response to the acetylcholine introduction.


PMID: 16193654 [PubMed - indexed for MEDLINE]

 

[Press]

Not JJ but from my research I would definitely say selank. Although it shouldn't effect heart rate. I assume you just mean an elevated heart rate due to anxiety? You don't have a high resting heart rate do you? So if you stop the anxiety you stop the times of an elevated heart rate.

I have seen various studies on rodents and cats etc relating to cardiovascular effects and heart rate was never effected. Although as you know humans are different.
QUOTE]


right now i take propranolol for anxiety but sometimes it drops my diastolic blood pressure to low. it took my resting HR from 70's to 50's which feels much better.im always stressing about something. so i need something that keeps HR low but doesnt drop blood pressure. to me it would only make sense that selank would have to control your heart rate to control anxiety.

 

[Elvia1023]

All the studies I have read have stated otherwise but it's a possibility. But you need to have you resting heart rate tested throughout the day. I am sure it will be fine so you wouldn't need to take anything. It's in moment of anxiety it will shoot up so I imagine if you control the anxiety your heart rate shouldn't be an issue.

How much cardio do you do? Cardio should be the first thing you think of imo.

Not JJ but from my research I would definitely say selank. Although it shouldn't effect heart rate. I assume you just mean an elevated heart rate due to anxiety? You don't have a high resting heart rate do you? So if you stop the anxiety you stop the times of an elevated heart rate.

I have seen various studies on rodents and cats etc relating to cardiovascular effects and heart rate was never effected. Although as you know humans are different.
QUOTE]


right now i take propranolol for anxiety but sometimes it drops my diastolic blood pressure to low. it took my resting HR from 70's to 50's which feels much better.im always stressing about something. so i need something that keeps HR low but doesnt drop blood pressure. to me it would only make sense that selank would have to control your heart rate to control anxiety.

 

[Elvia1023]

The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity.

Zozulya AA1, Kost NV, Yu Sokolov O, Gabaeva MV, Grivennikov IA, Andreeva LN, Zolotarev YA, Ivanov SV, Andryushchenko AV, Myasoedov NF, Smulevich AB.



Abstract

Examination of patients with various forms of anxiety and phobic disorders (according to DSM-4 criteria) demonstrated a considerable shortening of enkephalin half-life and reduced total enkephalinase activity in the blood during generalized anxiety, but not during panic disorders and agoraphobia. This was probably related to low blood concentration of endogenous inhibitors of enkephalin-degrading enzymes in patients with generalized anxiety disorders. Heptapeptide Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), which attenuates behavioral anxiety reactions and does not cause side effects typical of most anxiolytics, dose-dependently inhibited enzymatic hydrolysis of plasma enkephalin (IC50 15 microM). Selank was more potent than peptidase inhibitors bacitracin and puromycin in inhibiting enkephalinases. These results suggest that high efficiency of Selank in the therapy of anxiety and phobic disorders, including generalized anxiety, is due to its ability to inhibit enkephalin hydrolysis.


PMID: 11550013 [PubMed - indexed for MEDLINE]

 

[Press]

All the studies I have read have stated otherwise but it's a possibility. But you need to have you resting heart rate tested throughout the day. I am sure it will be fine so you wouldn't need to take anything. It's in moment of anxiety it will shoot up so I imagine if you control the anxiety your heart rate shouldn't be an issue.

How much cardio do you do? Cardio should be the first thing you think of imo. quote]



right it could also work in the reverse.ive had my HR tested throughout the day and got put on propranolol. i do cardio technically everyday only a 10 minute run on lifting days 30min on non lifting days. i add in sprints as well.

 

[johnjuanb1]

Out of the 3 I had in mine Selank is number one after more research. I was basically just after something that helped with anxiety. Everyone seems to really find benefits from it. It sounds like it would be great for me. Budget is limited so I had to take it off my shipping cart but I will try it out soon.

It was a choice between 2nd vial of LR3 or selank... had to go with the muscle growth

I agree. Selank is my choice and also noopept. I just ordered but this time I got all HGH enhancing stuff: prami, cjcDAC, GHRP2, ipamorelin, BPC 157 for my strained pec , and tadalafil for my strained pecker. Bahahahaha