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I would respectfully disagree with this point. It's very hard to crash your Estrogen levels on Exemestane (Aromasin) as long as you stay below 25mg per day. And there is absolutely no evidence to suggest that AIs have a direct effect of bone loss. However, androgens are known to downregulate Estrogen receptor signalling, so that one could make the argument that the T/E ratio should be held at a normal level. So if your test levels are 3x the upper normal, then estradiol should also be somewhat above the normal range.
Well I'll have to respectfully disagree.. I know many who have tanked their e2 on low dose aromasin..including many on this board... two years ago I was on 200mgs of test... I also took 6.25 aromasin 2 times a week... 6 weeks into my trt my blood work showed a e 2 of 15.. 6 weeks later it was 7... I know many who have lowered their e2 to unsafe levels on lower aromasin dosages.. it seems to have a accumulative effect over time.. will it do it to everyone ? No.. but it does happen more often than people realize. Now is being on higher dose test negate some of that? Sure.. and as I stated in this thread it's more about the ratio of test to estro than a estro number..
That being said the are numerous pages on the web along with studies that show bone loss with aromatase inhibitors... many take it from the mineral loss stand point.. there was also a video by a trt dr stating showing bone loss in some of his clients after stating aromatase inhibitors...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693896
https://www.hindawi.com/journals/jos/2011/230671
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