BERBERINE - before fasted cardio?

[iron lifter]

Was thinking of taking 500-1000mg berberine before fasted cardio to Wisk away some floating glucose. will that amount cause hypoglycemia?

 

[micro2000]

Others with real world experience can chime in and correct my assumption, but I am of the belief that much of berberine's glucose lowering effect is from inhibiting intestinal carbohydrases, similar to acarbose. Berberine has very poor bioavailability which leads me to believe any systemic effect is minimal.

 

[SouthernMuscle]

I use berberine daily, I wouldn’t want to take it on an empty stomach. especially 1000mg, the chance for stomach upset is high.

Also it’s primary mechanism of action, as i understand it, is through inducing ampk

Google warriors feel free to correct me

 

[luki7788]

if you want to use berberine to lower your morning sugar, I recommend that you try adding 500-1000mg to the last meal of the day

 

[MR. BMJ]

I actually have zero problems taking it on an empty stomach...thankfully. I take one cap at night and first thing in the morning (on empty stomach). Dosage is 500mg per cap.

 

[juggy38]

Others with real world experience can chime in and correct my assumption, but I am of the belief that much of berberine's glucose lowering effect is from inhibiting intestinal carbohydrases, similar to acarbose. Berberine has very poor bioavailability which leads me to believe any systemic effect is minimal.

Actually 500mg Berberine 3x a day was on par with 500mg metformin 3x a day.

Definitely not minimal.

 

[nothuman]

Nah berberine is better at the beginning of meals

 

[micro2000]

Actually 500mg Berberine 3x a day was on par with 500mg metformin 3x a day.

Definitely not minimal.

Oh I believe that berberine is having an effect, I just don't know how much is from intestinal carbohydrase inhibition or systemic effects. Berberine has been shown to act like acarbose in the intestines and is likely the reason for the diarrhea potential.

 

[Type-IIx]

Oh I believe that berberine is having an effect, I just don't know how much is from intestinal carbohydrase inhibition or systemic effects. Berberine has been shown to act like acarbose in the intestines and is likely the reason for the diarrhea potential.

While absolutely true that berberine's oral bioavailability is very low (<1%), its mechanisms are manifold. Its antidiabetic effects include insulin pathway regulation (liver, pancreatic islet cells), increased GLUT1 expression, AMPK activation, and gut microbiota modulation. See Liu, C.-S., Zheng, Y.-R., Zhang, Y.-F., & Long, X.-Y. (2016). Research progress on berberine with a special focus on its oral bioavailability. Fitoterapia, 109, 274–282. doi:10.1016/j.fitote.2016.02.001

 

[nothuman]

Others with real world experience can chime in and correct my assumption, but I am of the belief that much of berberine's glucose lowering effect is from inhibiting intestinal carbohydrases, similar to acarbose. Berberine has very poor bioavailability which leads me to believe any systemic effect is minimal.

Two ways to deal with the bioavailability concern

1. Take with milk thistle

or

2. take Dihydroberberine instead. It's 5x more bioavailable than regular berberine

 

[Elvia1023]

 

[micro2000]

While absolutely true that berberine's oral bioavailability is very low (<1%), its mechanisms are manifold. Its antidiabetic effects include insulin pathway regulation (liver, pancreatic islet cells), increased GLUT1 expression, AMPK activation, and gut microbiota modulation. See Liu, C.-S., Zheng, Y.-R., Zhang, Y.-F., & Long, X.-Y. (2016). Research progress on berberine with a special focus on its oral bioavailability. Fitoterapia, 109, 274–282. doi:10.1016/j.fitote.2016.02.001

Berberine, like curcumin, is an extremely interesting compound, but without significant bioavailability, many of these pharmacological effects are academic as the compound can never reach adequate concentrations to elicit such effects.

 

[Knight9]

Others with real world experience can chime in and correct my assumption, but I am of the belief that much of berberine's glucose lowering effect is from inhibiting intestinal carbohydrases, similar to acarbose. Berberine has very poor bioavailability which leads me to believe any systemic effect is minimal.

There is dihydroberberine which I am not sure of - could be great or could be marketing bS. I tell my close friends to take berberine with milk thistle because it enhances its absorption.


Edit..just saw Nothuman's post..lol.

 

[Type-IIx]

Berberine, like curcumin, is an extremely interesting compound, but without significant bioavailability, many of these pharmacological effects are academic as the compound can never reach adequate concentrations to elicit such effects.

Oh, my rationale for linking the particular paper I did was because it discusses the various methods employed to increase its bioavailability (none of which have been mentioned here). I'm really only in the habit of sharing practical research, at least I think that's what I do. With respect to curcumin, there are commercial preparations with high bioavailability on the market.

 

[Zarati]

Two ways to deal with the bioavailability concern

1. Take with milk thistle

or

2. take Dihydroberberine instead. It's 5x more bioavailable than regular berberine

What brand do you suggest for dihydro, couldn't find any on Amazon

 

[Knight9]

What brand do you suggest for dihydro, couldn't find any on Amazon

It's called GlucoVantage.

Nothuman, have you tried it?

 

[nothuman]

It's called GlucoVantage.

Nothuman, have you tried it?

Yea I've gone through several bottles by now but haven't had blood tests in a while to compare

 

[Zarati]

It's called GlucoVantage.

Nothuman, have you tried it?

Berberine 500mg Formula HCL Complex Supplement with Silymarin for Better Absorption, Cholesterol Support, Natural Alternative https://www.amazon.com/dp/B01JZSH3HA/ref=cm_sw_r_apan_glt_fabc_BZ9WZ8449BKZFG1FE6M2

I got this, it's berberine with milk thistle . Price is better

 

[Zarati]

The question is, is 100-200mg of dihydroberberine as effective as 1000mg of berberine hcl with milk thistle?
Huge difference price wise

 

[Vanilla Thunder]

https://www.amazon.com/Berberine-HC...&qid=1637074085&sprefix=dihydr,aps,177&sr=8-6

This one has the best label if that much dihydro is really in there. I've ordered it a couple times but I've never run any kind of test to see if / how much better it works.