What is amazing is that the FDA has approved increlex for use in short kids who weigh 40KG at a dose of up to 10mg a day (0.24mg per KG/day), but bodybuilders who are much more than twice that bodyweight are using only 50mcg a day and claiming great results off like $1day's worth. Costs for the kid can be $50k per year so how can one really expect results from using so little?
If a little kid is taking 200x the dose of a bodybuilder to grow (yep 200x) and the FDA says that is approved to be safe and effective, one can't help but wonder how effective 50mcg really is for muscle growth.
LR3 and rIGF doses can not be assumed to be similar surely now? LR3 is not affected by binding proteins like regular IGF is which is quickly bound up by IGFBP3. Since we're talking pharma grade rIGF1 costs you have to compare that with pharma grade LR3 from gropep/repligen/novozymes which is like $300/1mg while increlex works out to around $20/mg or less depending where you are getting it.
If long term use in kids has shown high doses of rIGF1 to be safe you might as well hit bigger doses that are still affordable and get better results.