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- Apr 8, 2012
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The past couple of years, my wife noticed that it has been a little more difficult to get her body to react to exercise and die the way had in years past. Last year, we had a full panel of bloodwork done, and her doctor put her on progesterone and a small amount of testosterone. Nothing performance-enhancing, just enough to bring her hormones back to where they should be (she’s 56).
Full disclosure, when she starts dieting for her upcoming summer/fall contests, we will utilize some primo, anadrol/anavar/winstrol in small amounts. However, none of this is currently being used.
Everything was clicking along, wonderfully, her body composition shifted back to where it should be, and her body was again reacting to nutrition and training the way that it had previously. However, a few months ago, she started noticing some acne on her face. Now, even before the HRT began, she’s always had intermittent issues with acne. Her doctor put her on Spironolactone, 25 mg in the morning, and 50 mg before bed.
After this, we slowly noticed that her body composition began to shift again. In the wrong direction. Additionally, her sex drive was down (I was fully prepared to chalk that up to the fact that she married a hideous fucking C.H.U.D., but she assures me that that is not the case!
).
We analyzed all of her training and nutrition supplementation, and the only thing that had changed over that four month period was the addition of Spironolactone. After doing a little digging, I discovered that in addition to it being a medication used for acne, as well as a diuretic (affections, we all know), it also acts as an anti-androgen.
Reading further, I saw that it is something that is given to men that are transitioning to female, although the amounts utilized were upwards of 200 mg per day.
This brings me to my question… Could this Spironolactone be blocking the absorption of the testosterone by her androgen receptors, thus negating the effects of the HRT? With all of the reading that I have done, I can’t find a clear indication of whether it blocks the production of testosterone, or the attachment to the androgen receptor.
We thought that it might be having some negative effect, so I suggested that she titrate the dose down, but she stopped cold turkey. It’s been about two weeks now, and her acne has not re-emerged, and the only difference that either of us can tell is that there seems to be some kind of rebound from the loss of the diuretic effect and she’s holding water like someone would a week after for competition.
If anyone has any knowledge of this compound under these circumstances, I would love to hear your feedback. I know she was only on 75 mg per day, but I figured that just as people can be hyper responders to androgens, it could be the same with a drug like Spironolactone.
That was kind of a scattergun method of giving information and asking a question, but this one has me stumped, and I would appreciate some help! Thanks in advance.
Full disclosure, when she starts dieting for her upcoming summer/fall contests, we will utilize some primo, anadrol/anavar/winstrol in small amounts. However, none of this is currently being used.
Everything was clicking along, wonderfully, her body composition shifted back to where it should be, and her body was again reacting to nutrition and training the way that it had previously. However, a few months ago, she started noticing some acne on her face. Now, even before the HRT began, she’s always had intermittent issues with acne. Her doctor put her on Spironolactone, 25 mg in the morning, and 50 mg before bed.
After this, we slowly noticed that her body composition began to shift again. In the wrong direction. Additionally, her sex drive was down (I was fully prepared to chalk that up to the fact that she married a hideous fucking C.H.U.D., but she assures me that that is not the case!
).We analyzed all of her training and nutrition supplementation, and the only thing that had changed over that four month period was the addition of Spironolactone. After doing a little digging, I discovered that in addition to it being a medication used for acne, as well as a diuretic (affections, we all know), it also acts as an anti-androgen.
Reading further, I saw that it is something that is given to men that are transitioning to female, although the amounts utilized were upwards of 200 mg per day.
This brings me to my question… Could this Spironolactone be blocking the absorption of the testosterone by her androgen receptors, thus negating the effects of the HRT? With all of the reading that I have done, I can’t find a clear indication of whether it blocks the production of testosterone, or the attachment to the androgen receptor.
We thought that it might be having some negative effect, so I suggested that she titrate the dose down, but she stopped cold turkey. It’s been about two weeks now, and her acne has not re-emerged, and the only difference that either of us can tell is that there seems to be some kind of rebound from the loss of the diuretic effect and she’s holding water like someone would a week after for competition.
If anyone has any knowledge of this compound under these circumstances, I would love to hear your feedback. I know she was only on 75 mg per day, but I figured that just as people can be hyper responders to androgens, it could be the same with a drug like Spironolactone.
That was kind of a scattergun method of giving information and asking a question, but this one has me stumped, and I would appreciate some help! Thanks in advance.
