- Joined
- Apr 9, 2021
- Messages
- 1,724
GH increases peripheral conversion of T4 to T3: this is a derangement in thyroid function, and is only considered an "improvement" by bodybuilders who consider crunk T3 numbers "improvement."I am interested in knowing how GH worsens hypothyroidism?
I heard that GH improves conversion of T4 into T3, which in theory, would improve hypothyroidsm.
What we see in patients with central hypothyroidism given rhGH is a diminished GH response (only a miniscule increase in serum IGF-I) and diminished peak GH <3 μg/L (>2x that of normal subjects) in response to provocative stimuli. But what seems to be the primary determinant in thyroid function derangement is the nature of the underlying pathology, consistent with this, central hypothyroidism was more common in patients receiving rhGH if they had structural pituitary abnormalities on MRI.