140 mg trenbolone acetate is more potent than 770 mg testosterone (directly via AR mechanisms) and presents multifaceted harms by other pathways, including antagonism of mineralocorticoid receptor (MR). The principal consequences of MR antagonism are electrolyte disturbances, impacting kidneys (consequences of impaired aldosterone action) and the development of hypertension and cardiovascular disease. That's just one chief factor involved, there are several more.
Of course, if someone has a high risk tolerance, they can go much higher with trenbolone.
Someone with nephritis at best and FSGS at worst, approaching potential renal failure, that person has absolutely no risk tolerance.