Using saline solution for peptides

Esc8p · May 23, 2012

I have access to lots of 0.9% Sodium Chloride Irrigation USP and was wondering if I could use it in place of bac water or acidic acid water in mixing peptides. I'm new to this and want to make sure everything is as it should be.

Thank you

crackrbaby · May 23, 2012

Here's what I've read by Datbrute

The following seems to indicate that GHRP-6 which is a simple peptide chain unlike IGF-1 which is more complex, is relatively resistant to degradation under the right circumstances at room temperature for almost five years.

The influence of the various buffer species (acetate, citrate, phosphate and borate) was shown to be different and the maximum stability of GHRP-6 was revealed to be in acetate buffer of pH 5.5-6.0. Degradation of GHRP-6 was greater in citrate-containing buffers than in acetate-containing ones. Furthermore, in the citrate-containing buffers, the higher buffer concentration caused greater degradation than the lower ones, but the concentration effect was negligible in acetate-containing buffers. Aqueous solution of GHRP-6 buffered with acetate (0.01 M, pH 5.5) showed a predicted t90% of 4.73 years at 20°C. - Degradation kinetics of growth hormone-releasing hexapeptide (GHRP-6) in aqueous solution, In Sik Ha… International Journal of Pharmaceutics Volume 144, Issue 1, 22 November 1996, Pages 91-97

That being said I'm going to go ahead and say saline should do fine.
.9% sodium chloride has a pH of 5.5 adjusted by Hydrochloric Acid