Metformin may be a poor choice for athletes (unless suffer from type 2 known diabetes), as it hinder the body ability to exert maximum performance (you may google exercise and metformin).
IGF1 will be much more suited tool to increase insulin sensitivity while further increasing the anabolic/anti-catabolic potential of the GH - http://www.professionalmuscle.com/forums/articles-forum/133700-gh-igf1-should-i-combine-them.html
Yeah, I have no idea what anecdotal evidence or studies you are looking at with that answer.
SEVERAL posters on PM run metformin (or Berberine for that matter) to offset the rise in fasting blood glucose that comes with GH use.
To the OP, go to the main ProMuscle forum and type Metformin into the search box and see the TONS of threads discussing this.
Metformin does have its downsides, but it is still the best option available to address high blood glucose levels caused by GH use. So what people should do is to measure their fasting blood glucose when on GH, and only in case it is excessive (say, >95mg/dL) take Metformin.Make a simply search on google, get into real data bases of scientific literature, and learn about the Metformin's negative effects on exercise, maximum performance, and also specifically on exercise's effects on glucose levels.
Metformin is suited for increasing insulin sensitivity, hence if an individual was diagnosed with diabetics then Metformin is necessary, but as an additive to GH regime for a healthy athlete in order to increase insulin sensitivity it's a poor choice and IGF1 is the solution you're aiming for
https://www.ncbi.nlm.nih.gov/pubmed/9153298/We have investigated the metabolic actions of recombinant human IGF-1 in mice genetically deficient of insulin receptors (IR-/-). After intraperitoneal administration, IGF-1 caused a prompt and sustained decrease of plasma glucose levels in IR-/- mice. Plasma free fatty acid concentrations were unaffected. Interestingly, the effects of IGF-1 were identical in normal mice (IR+/+) and in IR-/- mice. Despite decreased glucose levels, IR-/- mice treated with IGF-1 died within 2-3 d of birth, like sham-treated IR-/- controls. In skeletal muscle, IGF-1 treatment caused phosphorylation of IGF-1 receptors and increased the levels of the phosphatidylinositol-3-kinase p85 subunit detected in antiphosphotyrosine immunoprecipitates, consistent with the possibility that IGF-1 stimulates glucose uptake in a phosphatidylinositol-3-kinase-dependent manner. IGF-1 receptor phosphorylation and coimmunoprecipitation of phosphatidylinositol3-kinase by antiphosphotyrosine antibodies was also observed in liver, and was associated with a decrease in mRNA levels of the key gluconeogenetic enzyme phosphoenolpyruvate carboxykinase. Thus, the effect of IGF-1 on plasma glucose levels may be accounted for by increased peripheral glucose use and by inhibition of hepatic gluconeogenesis. These data indicate that IGF-1 can mimic insulin's effects on glucose metabolism by acting through its own receptor. The failure of IGF-1 to rescue the lethal phenotype due to lack of insulin receptors suggests that IGF-1 receptors cannot effectively mediate all the metabolic actions of insulin receptors.
I am a big believer in IGF-1 and it's overall effectiveness. I have posted about it for years even when most stated it is useless and would often post only pharm grade works (silly imo). But for hgh induced insulin resistance the main drug I would look towards would be metformin. If that caused people issues then berberine and well there is a big list of useful supplements one could use. IGF-1 obviously helps (very well in some cases)but I think metformin is better and is extremely cheap as well. I look at the insulin sensitivity effects of IGF-1 as a bonus in a sense. Melanotan 2 I look at in the same regard and it's insulin sensitivity effects are a bonus but I wouldn't just dose it for that reason. I have never noticed a decrease in performance from metformin either. The only thing for me is it can upset my stomach when I first start it even at just 500mg per day.
I should add IGF-1 would probably be enough for the typical hgh user and the combo of hgh/igf1 is highly effective for bodybuilding purposes. I can only see this being an issue in sensitive individuals or people who heavily use hgh and basically take it throughout every day for long periods. Although when I start 4iu hgh per day I will still be dosing 500mg metformin pre bed.