HGH downregulation/negative feedback loop?

VNV · Feb 3, 2015

If you start taking exogenous testosterone, your nuts produce less testosterone.

Does taking exogenous hGH also cause endogenous hGH production to decrease? For example, if I'm slamming 20 iu/day for three months straight, then come off completely, am I going to be producing a normal amount of hGH immediately after I come off?

Has anyone gotten labs to investigate this?

the_gift · Feb 4, 2015

I actually don't think so BUT you will build up antibodies by injecting GH on a regular basis.

Hammersmark · Feb 4, 2015

good question.

some of the vets I have talked to claim yes it does.. but maybe its just cause they got older

Anabolic Hercules · Feb 4, 2015

I am not sure how anyone could slam 20 ius a day of gh, even Chinese gh. So in all honesty, who knows what could happen at that extreme of dosing. There are probably not too many studies that are conducted on that one

Steroid Guru · Feb 4, 2015

synthetic hGH inhibitions
producing pituitary, so after using hGH is better to use peptides ghrp2 + mod1-29 to help the body to regain normal levels of hGH, this is for serious doses and prolonged use,

Captain Androgen · Feb 5, 2015

My guess would be that over time, the body would get used to the superphysiological doses of GH and reduce its own natural GH, but that's purely a guess based on the bodies constant change to achieve homeostasis. Very good question, nonetheless.

Jizzmo · Feb 5, 2015

Steroid Guru said:
synthetic hGH inhibitions
producing pituitary, so after using hGH is better to use peptides ghrp2 + mod1-29 to help the body to regain normal levels of hGH, this is for serious doses and prolonged use,

wrong, you dont need a "pct" for GH use.
the half life is too short to cause some kind of "shut down".

the body starts producing GH immediately after you stop using exogenous GH.

in fact youll still produce endogenous GH at night even while on supraphysiological doses of exogenous GH, assuming you dont jab your exo GH pre bed.

plus the antibody buildup is supposed to take place with cheap chinese GH, not with pharm GH and not with endogenous GH.