Cerulenin

[gelatine]

Anyone heard about this little guy at all?

http://www.drugbank.ca/drugs/DB01034
"Cerulenin produces metabolic effects similar to effects of leptin, but through mechanisms that are independent of, or down-stream from, both leptin and melanocortin receptors."

"It is also shown to inhibit feeding and induce dramatic weight loss in mice. "

http://en.wikipedia.org/wiki/Cerulenin
"Cerulenin is an antifungal antibiotic that inhibits fatty acid and steroid biosynthesis. In fatty acid synthesis, it has been reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, one of the seven moieties of fatty acid synthase, blocking the interaction of malonyl-CoA. It also has the related activity of stimulating fatty acid oxidation through the activation of CPT1, another enzyme normally inhibited by malonyl-CoA."

 

[Chris288]

BUMP!!!

 

[Newman]

How safe is this 4 long term use?

 

[gelatine]

How safe is this 4 long term use?

It appears to have mostly been tested in humans on extremely small sample sizes for experimental treatment of breast and colon cancer. It's unknown if it would even work for bodybuilding purposes, let alone if it would be safe at any dose. The "effects similar to effects of leptin" line was what caught my eye though, and it appears to be indicated for rapid weight loss in lab rats.

 

[gelatine]

Here's a study in mice that would seemingly be applicable:

**broken link removed**