clomid-Adex/clearance/blood work

Triguy · Aug 25, 2005

friends getting some saliva/blood work done to see how his PCT went, where can i get info on the clearance times of clomid & arimidex in relation to effects on HPTA? not drug testing.

how long after his last dose of 50mg clom & 1mg arimidex should he wait to get the saliva tests done??

Dad · Aug 25, 2005

A guess

My guess (and that's pretty much what it is) would be that you'll need to wait several half-lives of the substance with the longest half-life.

So, look up the half-life of Clomid and Arimidex.
Then, try to find out what the lowest active dosage is - the lowest dose that has any effect.
Then, see how many half-life times have to pass to be well past this lowest active dosage level.

For example, suppose the half-life on 50 mg of Clomid is 5 days, and the lowest active dose is 5 mg.
After 5 days, the 50 mg is down to 25 mg.
After 5 more days, the 25 mg is now down to 12.5 mg.
After 5 more days, the 12.5 mg is down to 6.25 mg.
After 5 more days, the 6.25 mg is down to 3.125 mg.

So, given this example, you're waiting 20 day minimum for the dosage to be below the minimum active dose.
Now, the question is are there residual side effects that have to be taken into account, and/or any problem with the liver enzyme pathways that clear this?

As you can see, it gets complicated fast, but this might be a place to start.

MikeS · Aug 25, 2005

I think the half life of clo and adex are both about 2days.

Triguy · Aug 26, 2005

very logical!

thanx dad
(that was weird typing that)

Triguy · Aug 27, 2005

14C-labeled clomiphene citrate is absorbed by the gastrointestinal tract. Fifty percent of the oral dose is excreted after five days, but radioactivity from labeled clomiphene appears in the feces up to six weeks after administration. However, the pharmacologic effect of clomiphene citrate is brief.

" got this from a website"

Im thinking your right on DAD, with the 20 days, doc said wait 30 days. He'll do 30 just to be sure. Ill let you guys know how the saliva tests go

This was the only website that gave me this info!

thanx!