First off, the studies put all the growth hormone releasing peptides (GHRPs) in the same category because their method of action is identical. That method of action was more fully described in the second article I wrote "Basic Guide: Growth Hormone Secretagogues" in my thread post #3 at:
http://www.professionalmuscle.com/forums/showthread.php?t=37381
GHRP-6 was first created, followed by GHRP-1 (sometimes called just GHRP, which was a modification that wasn't used much) followed by GHRP-2 and then Hexarelin. (Note: Ipamorelin is a more recently created interesting but weaker peptide)
Each one was a little more powerful then the previous one. The three (GHRP-6, GHRP-2 & Hexarelin) have been thoroughly tested. In fact the GH release potential is so well understood that newer studies involving these peptides usually focus on other potential uses. Hexarelin Cardio-protective, GHRP-2 reduction in muscle catabolism (distinct from GH release), GHRP-6 neuroprotective.
As far as GH release you can get more by going over the saturation dose. The penalty is not that great if you double of triple GHRP-6, even GHRP-2. Cortisol & prolactin will rise but still be in the high normal range and GH will end up being higher (but well below double that elicited by the saturation dose).
There was a study using Hexarelin that determined the top out dose for Hexarelin...meaning that there was not even a 1% increase in GH no matter how much Hex you administered above that top out level. That upper boundary was found to be 400mcg.
Unfortunately at that upper range you may (many studies demonstrate this, one study doesn't) desensitize to Hexarelin after a few weeks which is remedied by several days off.
With the saturation dose of GHRP-6 (and it appears to be so with GHRP-2 & Hexarelin) your body does not desensitize and is ready to accept another dose 3 hours later.
So at saturation doses you could administer the GHRPs every 3 hours or 6 times a day.
The GH pulse is created by GHRPs within 5 minutes and rises to a peak amplitude within 15 - 25 minutes. GHRP-6 actually acts faster then the non-peptide molecules GHS (GH Secretagogues) and maybe just a teeny bit faster then the other peptides. I believe the reason has to do with quicker action in the Hypothalamus.
Ingesting fats will blunt but not stop this GH pulse.
Ingesting Carbs will to a lesser extent blunt but not stop this GH pulse.
Ingesting protein will not interfere with this GH pulse.
So you do not want to eat fats and carbs within one hour previous to administering the GHRPs AND after administering the GHRPs you need to let them go to work for a minimum of 5 minutes and a maximum of 30 minutes before eating fats and carbs.
PRACTICAL NOTE: When you feel the hunger from the GHRPs you know it is active. Probaly five minutes later you can eat.
PRACTICAL TIP: 100mcg of GHRP will produce less hunger then higher doses.
REALLY PRACTICAL TIP: Pre-bed hunger can be intense with GHRPs. So to eliminate this you can administer the GHRP 30 minutes before bed. 20 minutes later when you feel that hunger eat a pre-bed meal or snack. Then go to sleep.
One further note of interest is that IF you are using GHRPs for a while and discontinue, your body will continue to release GH at a higher then pre-GHRP level for at least 14 days before falling back to pre-GHRP administration levels.
This effect is more pronounced in older people (if you ain't in your 20's you are older people...some of you are older older people and a few are older older older people but that is much better then being "don't know sh1t about sh1t younger people") whose signaling has lessened over time. By this I simply mean the signal to release GHRH has diminished & the signal to release Somatostatin has increased.
GHRPs can be used by themselves and they will almost always create a GH pulse lasting 2 hours. This happens in 90 year olds, in young, middle aged and older men & women (at all stages of the menstrual cycle), in the obese and in those with diabetes...
The other companion peptide (hormone) is Growth Hormone Releasing Hormone (GHRH). It is THE hormone responsible for releasing GH BUT it is a crapshoot if you take it by itself.
The reason is that THE inhibiting hormone Somatostatin is still doing its thing. Its thing is primarily playing a part in modulating GH release by dampening release.
The GHRHs are available to us as Sermorelin (basically just native GHRH); modified GRF(1-29) (basically native GHRH with a few amino-acid substitutions to protect it from quick degradation) and CJC-1295 (basically the modified GRF(1-29) plus a compound that isn't an amino acid but acts as a magnet for albumin which circulates in the blood thereby conveying longer life when injected).
When you administer GHRH the amount of GH that is released depends primarily on whether Somatostatin (the inhibiting hormone) is active. If Somatostatin isn't active and there is a natural rising GH pulse, taking GHRH at that time will produce a larger pulse of GH then if it is administered during a natural falling GH pulse.
So as Somatostatin increases it checks the activity of GHRH.
This is one of the primary reasons that the GHRPs when taken with GHRH guarantee a large GH pulse. The GHRPs have their own action AND they inhibit the inhibiting hormone Somatostatin. By blocking Somatostatin administered GHRH is free to act positively and GH release will be magnified.
This gets us into the synergy we talk about so frequently.
So you could create a lot of GH by creating 8 pulses a day spread out every 3 hours by co-administering a GHRP and a GHRH such as Sermorelin or modified GRF(1-29) at saturation dose every 3 hours.
Since we need to sleep for practical purposes this limits things to six administrations per day.
Damn...this turned out to be a long post. Maybe the people that PM me asking for a quick summary of all of this could read this and get a solid general idea of what we are talking about.
Anyway Sam I KNOW I answered your question. If this post raised more curiosity and questions GREAT! Just ask and if I've had my coffee I'll be happy to answer them.
.gif "IP Gear")
Just curious to see what would happen. Maybe he will explode? Maybe he'll win the lottery? Seriously though if 72 grams would make you win the lottery what would 76 grams do?
