ghrp-6 useful in conjunction with gh at all?

[mville1035]

is there any use of ghrp6 in conjunction with regular hgh? it covers ghrp6 with cjc1295 all over but i dont have nor plan on having cjc so would ghrp6 be good with my regular hgh say 3x daily for short bursts / spikes in my gh levels?
respect,
mville1035

 

[likkayouth]

There isnt much info on ghrp-6 ...

In this forum??????????????????

 

[Jarconis]

I do 250mcgs before bed every day, and just run my gh eod

 

[Smooth_Silk]

There isnt much info on ghrp-6 and i can get it dirt cheap, is there any point to using it if already running hgh?
respect,
rassler125

also has anyone posted a profile for ghrp-6 i cant find as much info on it as say cj1295 for some reason... thanks for any help...

um what about dats wholeeee guide lol

 

[mville1035]

um what about dats wholeeee guide lol

ok, i retract that statement, hows this, theres not information on what i would like to know...
is there any use of ghrp6 in conjunction with regular hgh? it covers ghrp6 with cjc1295 all over but i dont have nor plan on having cjc so would ghrp6 be good with my regular hgh say 3x daily for short bursts / spikes in my gh levels?
respect,
mville1035

 

[mville1035]

bump for the brute?

 

[Bobaslaw]

The pituitary has negative feedback mechanisms. Somatotrophs have HGH receptors just like other tissues in the body. If Somatotrophs HgH receptors are overly stimulated via exogenous GH, downstream signaling processes will blunt that somatotrophs responsiveness to GHRH and most likely GHS (GHRPs).

If combining both GH and GHRH/GHS, I would make sure that you use each compound out of the window of activity of the other for maximum benefit.

 

[mville1035]

The pituitary has negative feedback mechanisms. Somatotrophs have HGH receptors just like other tissues in the body. If Somatotrophs HgH receptors are overly stimulated via exogenous GH, downstream signaling processes will blunt that somatotrophs responsiveness to GHRH and most likely GHS (GHRPs).

If combining both GH and GHRH/GHS, I would make sure that you use each compound out of the window of activity of the other for maximum benefit.

so lets say this... there are 24 hours in the day... gh has a 12 hour half life correct? so for the remaining (4 considering i sleep 8) i could probably use ghrp6 with effectiveness? i need the help in appetite! lol
respect,
rassler125

brute where are ya brother?

 

[Bobaslaw]

so lets say this... there are 24 hours in the day... gh has a 12 hour half life correct? so for the remaining (4 considering i sleep 8) i could probably use ghrp6 with effectiveness? i need the help in appetite! lol
respect,
rassler125

brute where are ya brother?

See Dats post:
http://www.professionalmuscle.com/forums/showpost.php?p=488753&postcount=374

A 7.5 IU dose is active for 12 hrs. 15 IU dose is active for 24 hrs. Speculation dictates that an approx. 4 IU dose would have a 6hr rise to falloff...

Going by this you could most likely plan a decent strategy

 

[DatBtrue]

would ghrp6 be good with my regular hgh say 3x daily for short bursts / spikes in my gh levels?
respect,
mville1035

What you want with GH is testosterone. Testosterone will enhance GH and reduce the interval of time that synthetic GH (rhGH) suppressed natural GH release.

Note the dose used was only about 1iu.

From: Short-Term Testosterone Supplementation Relieves Growth Hormone Autonegative Feedback in Men, JOHANNES D. VELDHUIS, The Journal of Clinical Endocrinology & Metabolism 89(3):1285–1290

CONCLUSION:

"The current analyses reveal that short-term Testosterone (Te) supplementation in normal middle-aged and older men stimulates basal and pulsatile GH secretion, attenuates rhGH-induced suppression of basal GH secretion, and facilitates initial recovery of GH concentrations from autonegative feedback. This ensemble of actions would, in principle, limit the duration of autoinhibition and enhance GH pulse renewal."

INCREASE in BASAL GH

"Numerically, the absolute increment in basal secretion induced by Te repletion under GH autofeedback was approximately 30 ug/24 h or 12% of total daily GH production."

INCREASE in PULSATILE GH

"Te administration stimulates pulsatile and total daily GH secretion by 2-fold."

REDUCES GH NEGATIVE INHIBITION

"Te repletion, but not Pl, reversed the decline in GH concentrations 4 h after controlled feedback imposition (Fig. 6). Specifically, Te exposure elicited significant recovery (positive slope) of suppressed GH concentrations 3 h after the rhGH feedback signal. More rapid initial escape from autoinhibition also occurs in Te-sufficient midpubertal, compared with prepubertal, boys (6). The precise mechanisms that mediate postfeedback recovery of endogenous GH secretion in the human have not been established."​

 

[Bobaslaw]

Brilliant! Now that is another remarkable find, Dat!

 

[mville1035]

thanks dat, good thing im already on a decent amount of test
do you agree with bobaslaw in the respects of ghrp and hgh not being run congruantly? I am really after the appetite increasing with the ghrp!
respect,
mville1035

 

[VictorZ06]

thanks dat, good thing im already on a decent amount of test
do you agree with bobaslaw in the respects of ghrp and hgh not being run congruantly? I am really after the appetite increasing with the ghrp!
respect,
mville1035

The "GHRP-6 appetite" or hunger pains will soon linger away. I got massive hunger pains when I first started, no longer. Toss some EQ with that test you are taking and see what kind of munchies you'll get.

 

[mville1035]

The "GHRP-6 appetite" or hunger pains will soon linger away. I got massive hunger pains when I first started, no longer. Toss some EQ with that test you are taking and see what kind of munchies you'll get.

never had luck with eq increasing my appetite for some reason... also feel that nandralone was much more suited for my goals so ive been running the following

dbol 1-4 35mg/day
drol 5-9 50mg/day
sust 1-4 600mg/week
enan 5-16 750mg/week
dbol 13-16 35mg/day
npp 1-16 150mg eod
hgh 5ius a day
insulin 3x a week 5ius


respect,
mville1035

 

[DatBtrue]

thanks dat, good thing im already on a decent amount of test
do you agree with bobaslaw in the respects of ghrp and hgh not being run congruantly? I am really after the appetite increasing with the ghrp!
respect,
mville1035

Maybe I should have posted more detail from the above study. There is another companion study that also indicates that testosterone inhibits IGF-1 negative feedback.

I just kinda thought that this stuff was common knowledge but it turns out my head is the only one filled with this stuff. I might post more detail in my thread on this so I can dump it from my head to make room for dreaming about beautiful women again.

What I left out from the above study was that testosterone also blunted GH response to GHRP-2. If you take the research forward into more current studies you'll see that the reason appears to be that there is some duplication on mode of action between the GHRPs & testosterone.

This duplication comes in the form of inhibiting Somatostatin. So IF testosterone is already doing that then the GHRPs which also do that will be less effective.

But testosterone WILL NOT inhibit GHRP-6's hunger effect (I don't think). The reason is simply that this effect comes from exciting neurons in the hypothalamus. So if you want the hunger effect use it here and there.

Victor was correct that the effect wanes after a while ...so you might want to cycle it in and out with something else that makes you hungry.

 

[GoneForever]

Dat, what is your avatar?

 

[DatBtrue]

Dat, what is your avatar?

An injured little girl amidst death & destruction ....nothing more than cannon fodder to some. She deserves better.