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Is there a risk of eye sight problems with Cardarine?

nothuman

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Sorry another cardarine thread but something caught my attention on another site.

Here is a good write up of it
https://www.selfhacked.com/blog/gw501516-cardarine/#2_Cardarine_Benefits_the_Heart

at the bottom, I am reading the comments section and it appears to be a thing if you scroll down, which I was not aware of.

Here is a copy/paste of a comment:
"Hello, the eye side effects seems very concerning, what is happening seems similar to age related macular degeneration (AMD). Not point in looking good if you get blind.
I found these studies that perhaps could help as they help with AMD, as the problem there also is neovascularization growth of new blood vessels.
Just for your information to perhaps discuss with your doctors,
Atorvastatin (perhaps easier, cheaper and better than getting injection into the eyes)
(Statins also lowers one factor involved in AMD, that is called VEGF (vascular endothelial growth factor).
https://eye.hms.harvard.edu/news/pa...n-show-improvement-high-dose-statin-treatment
https://www.reviewofophthalmology.com/article/amd-and-statins-is-there-an-association
And a blood pressure medicine, telmerisartan, as it seems to reduce many of the mediators involved in AMD as well (including VEGF and other factors)
Hypertension is a potential link between cardiovascular pathologies and eye diseases. A large amount of information has demonstrated the presence of a RAS (refers to how blod pressure is regulated) in the retina which is greatly spread in the vasculature. To date, findings from epidemiological studies indicate an association between AMD and hypertension. Moreover, studies in vitro and in vivo show that Ang II contributes to sub-RPE deposit formation and CNV development and that these events can be improved by Ang II receptor blockers (ARBs). However, the utility of ARBs for the treatment of eye AMD is still to be determined. In terms of DR (diabetic retinopathy), there is documented evidence showing a clear contribution of Ang II to the development of this disease. Therefore, the use of ARBs (including telmerisartan) can confer retinoprotection and arrest the progression of DR.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176806/
Study with atorvastatin with aspirin
Cholesterol-Lowering Statin Drugs and Aspirin Show Protection Against Wet AMD | blindness.org
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939755/ (just aspirin for ARMD)
A animal disease model that shows telmerisartan and aspirin could work for a similar condtion that happends in the kidneys
https://www.researchgate.net/publication/41909567_Combination_of_aspirin_with_telmisartan_suppresses_the_augmented_TGFbsmad_signaling_during_the_development_of_streptozotocin-induced_type_I_diabetic_nephropathy"


Personally, I haven't noticed any eye sight issues from all the times I have used it but I do take eye health supplements (Telmisartan is also shown to prevent macular degeneration).

Anyone have knowledge or experience with this possible side effect?
 

rmtt

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I've been on it since last September or so....and only bp support I take is Carditone and whatever benefits I get from Ubiquinol and the other supplements.

But I just had my annual eye exam a few weeks ago as I've worn contacts since I was a teenager.

For the last 2-3 years, they have done this type of imaging that shows all the vascular parts in the background....can't remember what it's called. But since diabetes runs in my family....I get it done.

It came back perfectly fine. It's a cool looking image too.....looks like a deep sky time lapse pic from the Hubble Telescope.

Sent from my LG-H871 using Tapatalk
 

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