Broscience
There will be only one pass through the liver
No that's not true.
There won't be a first pass via the
hepatic portal vein because the drug is being introduced directly into systemic circulation. However, there will be as many passes through the liver as the half-life of the drug permits. Consider,
-- An average person has
5 liters of blood (~5 quarts);
-- The length of time it takes blood to circulate throughout the body depends on numerous factors including body mass and heart rate but on average
**broken link removed** i.e. in one minute all of a persons blood will have passed through their heart;
-- Besides the hepatic portal vein the liver is fed blood directly from the
aorta which comes from the left-ventricle;
-- The half-life of
Stanozolol is 1 day,
methandienone is 4-6 hours,
oxymethelone is 8-9 hours so on a very conservative estimate the liver will receive an injection of blood (via the aorta and the proper hepatic artery) containing Stanozolol
at least 300 times (ie. 5 hours x 60 minutes). That blood will flow out of the liver and back into systemic circulation at a much lower rate but it will flow out eventually because the liver can only contain a limited amount of blood -- so the volume entering will eventually equal the amount exiting. So we can safely assume the liver will handle the Stanolozol contining blood
hundreds of times.
so it will still be liver toxic but not as harsh.
This is doubtful. The toxicity is unchanged because the liver will eventually process the same quantity of the substance (it would actually process more of the drug when it is injected because of greater bioavailability) . Injecting the drug improves its bioavailability because you are not relying on absorption via the stomach wall and small intestine and you are avoiding the first pass liver metabolism effect which destroys a siginificant quantity of the drug (precise amount depends on the drug in question). You could argue that because the liver doesn't receive a bolus of the drug (via the hepatic portal vein) the liver is not taxed to the same extent in a given period of time and it has time to replenish its glutathione and glucuronide reserves. Maybe, but not likely. If you are concerned with sparing the liver from processing a large dose of the drug all at once then you are better off assisting the liver in its work of glucuronidation, methylation and glutathione conjugation.
Problem with injectable dbol is the half life is so short you should really inject it multiple times per day, but if you really want to thats how I would go about it.
Then in this case the liver will never really get an AAS-free period to replenish itself so the bolus argument becomes moot.
PS:- Are you the broscientist from that crap forum "
Steroid Encyclopedia"?