I am prescribed t3 and t4 for hypothyroidism. I take my t3 spaced evenly 3x a day and find that this keeps my energy consistent. I have not found that an empty stomach is necessary for t3, nor have I noticed absorbtion issues related to any food or mineral intake in the period preceding or after administration. The same cannot be said for t4 and as such I take that in the middle of the night.
Bodybuilders and many (most every) coach fuck t3 dosing up. While the half-life is 12-24 hours, the time for which it is bioactive is much shorter, more like 4-6 hours. This is why people with actual thyroid issues at a minimum dose am and pm.
I think this mistake dosing is also a reason that competitors suffer muscle loss form t3 - taking 75mcg all in one dose is much more catabolic to muscle than woudl be the same total amount spread throughout the day. Moreover, the side-effects will be mitigated by spread dosing and energy will be more consistent such that you may even avoid the late afternoon crash that comes later in a prep.
i partially agree. :lightbulb:
you mentioned some -imo- VERY Important points that many oversee
BUT
the term bioactive is not correct
t3 is FULLY ABSORBED within 3-4 hours (or 4-6, whatever)...
it is ACTIVE all the time. as long as it remains in your body.
however i definitely agree that taking 75mcg all at once is much different from taking 37.5mcg twice a day...
taking a huge does at once leads to a much higher spike, since everything "hits" you at once... this possibly leads to more catabolism too, as you say.
keep in mind that t3 interacts with numerous other hormones, upregulation, downregulation etc. a high dose at once possibly causes a cascade of catabolic processes, much worse than the same dose but spread out into smaller portions..
a single t3 dose is still "bioactive" after 24hours though.
its just better to spread it out for even levels and less spikes. :headbang: