1000iu HCG EOD was too much for me. The most I could tolerate was 500iu EOD.
Personally, I don't like HCG. Especially in large doses, it raises my estrogen too much and gives me anxiety and gyno, and in large doses it made me feel slightly unwell.
In 29 years of steroid use, I never ran HCG before my fertility protocol. In very small doses like Dr John Crisler used to advocate of 100iu per day, it wasn't bad and may have even enhanced my libido. But in large doses it made me feel anxious and unwell, and gave me noticable gyno. It was necessary when I was on my fertility protocol, but as soon as my wife was pregnant, I stopped using HCG and have never used it since. But everyone's different, and I know some guys love the stuff.
I didn't notice any perceptible side effects after adding in the HMG, but it's hard to separate out the effects when you are running multiple compounds at the same time (Test, HCG, HMG, Proviron, etc.)
At any rate, none of the side effects were enough to make me stop the protocol. Test + HMG + HCG gave me my beautiful little baby daughter, who is 18 months old and happy and healthy now. The fertility protocol was expensive and a pain in the ass, but it was all worth it to have my baby girl call me Daddy.