Adding dbol in morning for cortisol

MrCyp · Dec 30, 2009

I've heard a low dose of 5mg-10mg of dbol added every morning can drasically reduce cortisol for the remainder of the day. Is this true and does anyone use it for this reason? Presuming that dose should have no sides it seems like maybe a logical addition to HRT or even when just on a cycle?

doug1 · Dec 30, 2009

sounds like a good plan to me!

KillerStack · Dec 30, 2009

Why do you want to suppress cortisol?

KillerStack · Dec 30, 2009

According to some Russian stuff I've read dbol increases cortisol acutely. This was seen as a good response. In athletes who "abused" steroids there wasn't this increase in cortisol which was seen as a negative and these athletes had poor performance increasing response to AS therapy. Low cortisol was correlated with poor performance, poor work capacity. They had this test where they administered dbol to athletes and measured cortisol and if it was low it may have meant the athlete was doing too many steroids and was no longer responding favorably. Cortisol isn't all bad or we'd all be doing lots of Cytadren and feeling wonderful.

This old paper seems to say dbol increases cortisol, at least acutely.

Journal of Clinical Endocrinology & Metabolism Vol. 32, No. 2 232-240
doi:10.1210/jcem-32-2-232
Copyright © 1971 by the Endocrine Society.

Effects of Anabolic Steroids on Hormone-Binding Proteins, Serum Cortisol and Serum Nonprotein-Bound Cortisol
JOSE BARBOSA, ULYSSES S. SEAL and RICHARD P. DOE

Metabolic Research Section, Minneapolis Veterans Administration Hospital Minneapolis, Minnesota

Department of Medicine, University of Minnesota Minneapolis, Minnesota
Department of Biochemistry, University of Minnesota Minneapolis, Minnesota

The effects on plasma proteins of the anabolic steroids oxymetholone, methandrostenolone, stanozolol, fluoxymesterone, oxandrolone, norethandrolone, ethylestrenol, nandrolone phenpropionate and methandriol dipropionate, as well as 17{alpha}-methyltestosterone, given orally and sublingually, testosterone propionate sublingual and parenteral aqueous testosterone, were studied on both volunteers and patients. The responses of thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), cortisol-binding globulin (CBG), serum cortisol and nonprotein-bound cortisol (NPC) were studied. The 17{alpha}-alkylated anabolic steroids induced marked changes, with significant elevations of TBPA and depression of TBG; CBG was significantly increased by oxymetholone and methandrostenolone. Both the latter steroids have conjugated and unsaturated resonating systems in ring A. On the other hand, the non-17{alpha}-alkylated androgens did not produce these changes. The C-3 ketone group, absent from ethylestrenol, seemed also to be important for effects upon these plasma protein concentrations. These effects on plasma proteins are dose related and different from the ones obtained with estrogens or during an acute phase reaction. Only methandrostenolone produced a significant increment in cortisol, and none of the anabolic steroids significantly changed NPC. A negative correlation (r= –0.78; p<0.01) was found between the ability to produce nitrogen retention in man and the degree of depression of TBG serum levels, for different anabolic steroids. It is concluded that in general a 17{alpha}-alkyl group, and to a lesser degree a C-3 ketone group, are necessary for those changes in plasma proteins. Additional unsaturation in ring A (other than the {alpha}, β unsaturation) may result in changes in CBG and is consistent with the effect of estrogen on this protein.

musicmann89 · Dec 30, 2009

d-bol increases cort.

MrCyp · Dec 30, 2009

It increases cortisol, jeez thats nuts. All these years bro's have been saying it lowers it.

Pumped1 · Dec 30, 2009

vit-c helps lower it

KillerStack · Dec 30, 2009

MrCyp said:
It increases cortisol, jeez thats nuts. All these years bro's have been saying it lowers it.

Well, don't forget that some steroids can increase cort because they have anti-cortisol effects, blocking cortisol receptors or what have you. I'm not sure about dbol specifically but some steroids do this. It can still have an overall "anti-cortisol" effect even if plasma cort goes up. So it's a bit complicated.

And you may not want to lower it anyway, like I said before.

myosin · Dec 30, 2009

2nd

KillerStack said:
According to some Russian stuff I've read dbol increases cortisol acutely. This was seen as a good response. In athletes who "abused" steroids there wasn't this increase in cortisol which was seen as a negative and these athletes had poor performance increasing response to AS therapy. Low cortisol was correlated with poor performance, poor work capacity. They had this test where they administered dbol to athletes and measured cortisol and if it was low it may have meant the athlete was doing too many steroids and was no longer responding favorably. Cortisol isn't all bad or we'd all be doing lots of Cytadren and feeling wonderful.

This old paper seems to say dbol increases cortisol, at least acutely.

Very good point KS- too low of cortisol can wreck havoc on you... extreme lethargy, muscle weakness, poor concentration, etc. I think that is a part of cortisol many may not think about. It's a fine line- you want it low, but not beyond normal nor obviously too high.

almard · Dec 30, 2009

It works very will during your Post cycle, if you wan't to come off.....should be in the morning and no more than 15 gram...

minister · Dec 30, 2009

I have read studies in which 10 mgs of Dbol does decrease cortisol, I have been doing this during my PCT for years, it has worked well for me.

taslajrisi · Dec 30, 2009

lowers cort

The Brief History of Dianabol
Dianabol is the second anabolic androgenic steroid ever created after the introduction of various forms of testosterone such as testosterone suspension. It started out as a cooperative project of Ciba and of a doctor for the US weightlifting team, Dr. John Zeigler. The project aimed to develop a drug that would serve as an equalizer for US athletes. Thus, in 1956, Dianabol was born. The original package insert of Dianabol claimed that a daily dose of 10 mg would be enough to replace androgens in the male body completely, and that the said dose could increase anabolic processes by 5 times than the normal. It was also said to reduce natural cortisol to about 50 to 70 percent of its normal value. At present, Dianabol is known as one of the most effective steroids for bulking. Even though its production has stopped in the US and in Western Europe, Dianabol is still being manufactured in Asia and many East European countries.

Everything i have read says it reduces cortisol. I like taking one or two 10mg tabs preworkout only and it works great.

MrCyp · Dec 30, 2009

I wonder how it could reduce cortisol and at the same time increase androgens and increase anabolic properties in a single 10mg dose when it only has a 4hr half life. Wouldnt that mean it would only drop cortisol and increase androgens for only 4hrs.

oldfella · Dec 31, 2009

MrCyp said:
I wonder how it could reduce cortisol and at the same time increase androgens and increase anabolic properties in a single 10mg dose when it only has a 4hr half life. Wouldnt that mean it would only drop cortisol and increase androgens for only 4hrs.

NO, this means it will reach maximum effeciancy in 4hrs. after that it will begin to decline until it has reached its' 8 hr (approx) lifespan in your system. That is why it was always more effective to take it three or four times a day.

As for cortisol, you can mega dose vit c and this will act as a buffer for cortisol effects in the body. >10,000mgs should help.

KillerStack · Dec 31, 2009

taslajrisi said:
The Brief History of Dianabol
Everything i have read says it reduces cortisol. I like taking one or two 10mg tabs preworkout only and it works great.

Yeah but have you seen any actual human studies showing this?

Lancet. 1976 Oct 2;2(7988):699-702.
"Anabolic" effects of methandienone in men undergoing athletic training.

Hervey GR, Hutchinson I, Knibbs AV, Burkinshaw L, Jones PR, Norgan NG, Levell MJ.

After failure to confirm an anabolic action of testosterone and its derivatives in rats, methandienone ('Dianabol', an "anabolic steroid" used by athletes) has been given to 11 athletic men during a course of weight-training, in a double-blind, crossover experiment. The dose of methandienone was 100 mg/day for 6 wk. Body weight and composition, muscular strength and performance, and indices of endocrine function were studied. Compared with the placebo period, on methandienone the subjects gained weight (mean 3-3 kg +/- 0-6 kg) and accumulated a disproportionately large amount of potassium (420+/-68 mmol); the increase in weight was confined to the lean part of the body, and the muscles increased in size. Strength and performance improved over each training period, but not significantly differently on drug and placebo.On the drug, plasma-cortisol concentration and urinary cortisol excretion increased, and plasma-testosterone decreased.Although the weight and body-composition changes may demonstrate an anabolic action of methandienone in man, they may alternatively have been caused by an increase in intracellular fluid, and the question of anabolic action therefore remains open.

minister said:
I have read studies in which 10 mgs of Dbol does decrease cortisol, I have been doing this during my PCT for years, it has worked well for me.

Can you find the study again maybe?

And of course it works great for PCT. You're still on a potent anabolic. "Post cycle" is probably the wrong term to use in this situation also.

KillerStack · Dec 31, 2009

MrCyp said:
I wonder how it could reduce cortisol and at the same time increase androgens and increase anabolic properties in a single 10mg dose when it only has a 4hr half life. Wouldnt that mean it would only drop cortisol and increase androgens for only 4hrs.

Like oldfella said it's not gone in that time. But even if it were pretty much gone from the blood it doesn't mean the cellular events it triggered stop at that very moment. In a steroid virgin even 10mg of dbol only is going to cause a net gain in muscle IME, despite the short half-life. Even something like Anavar has been shown to do that at that dosage level done once daily, though in a study the researchers speculated that it might give better results if split twice in a day due to the short half-life.