Well, first thing you need to know is that I'm a tightwad, so if I was comfortable with a lower dose, I'd stay there. When I first started, I jumped up to 4iu very quickly and had very bad carpal tunnel, so I went back down to 2.5-3 for many months. Noticed slow steady fat loss even in an excess calorie state, except when combined with insulin. Much better sleep.
About 6 months ago, I began dieting (starting around 12%bf) - a long term diet designed to prevent any rebound. Basically I just started using fat burners and slowly cut back my calories. It was at that point I bumped it up to 4iu/ed in the a.m., and I went a month doing 8iu/eod to see if that made a difference (no difference noticed). I noted quicker steady fat loss and very little muscle loss, even in the presence of t3 which is always very catabolic to me. I am down around 6% now with very little suffering involved. My goal is to get rid of my love handles completely, and while I look shredded everywhere else, there is still some protrusion on my sides. So, I've recently bumped it up to 5iu to see if I can achieve this goal quicker.
Anabolics were used off and on throughout. The gh seems to intensify the effects a bit and decreases the loss of gains during pct.