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BIG A ? "Metformin Lowers Testosterone Levels "

Ashop

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Metformin Lowers Testosterone Levels

The results of this study were just published. There have been reports of metformin raising levels of SHBG in patients with type 2 diabetes, but this is the first report that I am aware of showing a decrease in total testosterone in normal men from metformin.

Saudi Med J 2002 Aug;23(8):934-7

Effects of short term metformin administration on androgens in normal men.

Shegem NS, Nasir AM, Jbour AK, Batieha AM, El-Khateeb MS, Ajlouni KM.

National Center for Diabetes Endocrinology and Genetics, Jordan University Hospital, Amman, Jordan.

OBJECTIVE: To study the effect of metformin on androgens in normal men.
METHODS: A total of 12 healthy males volunteered to participate in the study. A blood sample was obtained from each of them and analyzed for the following: Testosterone (total and free), sex hormone binding globulin dehydroepiandrosterone sulphate, 17-hydroxyprogesterone, luteinizing hormone, and follicle stimulating hormone. In addition, each participant was subjected to a glucose tolerance test and his insulin level was measured. Metformin 850 mg twice daily for 2-weeks was given to each subject after which the above tests were repeated. A paired t-test was used to assess the statistical significance of any observed differences before and after metformin.
RESULTS: After metformin administration, there was a significant reduction in serum level of total testosterone (p=0.0001), free testosterone (P=0.002), and 17 hydroxyprogesterone (p=0.0001). There was also a significant increase in serum level of sex hormone binding globulin (p=0.009) and dehydroepiandrosterone sulphate (P=0.0008). Serum levels of luteinizing hormone and follicle stimulating hormone showed no significant changes. Similarly, there were no changes in fasting plasma glucose, fasting serum insulin, weight, or blood pressure. CONCLUSION: Metformin administration was associated with a reduction in total testosterone, free testosterone, and 17-hydroxyprogesterone and an increase in sex hormone binding globulin and dehydroepiandrosterone sulphate in normal males. The clinical significance of these findings needs further investigation.

Later, Shammy
 

Big A

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A 12 people 'study', especially if it's not properly controled doesn't have any real medical importance. I am not saying its wrong, but it would have to be researched further.
Most bb's use metformin on gear, so it doesn't matter if natural test gets reduced, 'cause a geared bb doesn't have any natural test anyway.
 

MikeS

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BigA quite a bit like what I was going to say. When using with a cycle, we are pummeling our HPTA anyway. This probably wont make much of a difference. Maybe in a totally natural athlete...
although Im not aware what significance those numbers have or mean.
Interesting post though!
 
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