Thanks for the reply, much appreciated. Not taking any biotin that I'm aware of.
Here are my IGF-1 and IGFBP-3 results, the first one was done at LabCorp and the 2nd one (and binding protein) done at ARUP Labs (local lab sent it out).
- First
- IGF-1 419 ng/mL 83-233[/INDENT]
- Second
- Prolactin 5.9 ng/mL Range: 2.1 - 17.7 ng/mL
- IGF-1 397 ng/mL Range: 83 - 240 ng/mL
- IGFBP-3 6840 ng/mL Range: 2474 - 5208 ng/mL
Everything else-- blood glucose levels, liver enzymes, etc-- all were normal/within range. Up until a few months ago I was using some Masteron as an adjunct to my TRT but stopped in early June. These labs were done in July. I was still using 50,000 IU/week of Vitamin D2 during these labs as well as exemestane to manage E2. Since I've had a clear-ish MRI (the -ish being the heterogeneous enhancing area) and a normal OGTT, I'm wondering whether the combo of Vit D, exemestane, and testosterone contributed to this increased IGF-1? Hard to say. It's all very weird.
I have found a few case reports of people with a similar presentation to me (elevated IGF-1, normal OGTT) finding tiny microadenomas (~3mm) on high-resolution 3T MRIs. In those cases their IGF-1 normalized after surgery. In one case, the woman had a tiny microadenoma on MRI, the surgeon couldn't find it during surgery, they removed 1/3rd of her pituitary in the region where the MRI showed the tumor, and her IGF-1 normalized after surgery.
In the absence of any symptoms other than heat intolerance and sleep apnea,
I think I'm going to ask my endocrinologist to re-test in a few months and do a 3T MRI if IGF-1 is still elevated. Thoughts? Ideas?