Fenugreek?...

[6.8SPC]

Anyone use this supp.? I have been reading about 4-hydroxisoleucine and its effects on glucose/insulin metabolism and was wondering if anybody has used fenugreek for this purpose? What were the results if any? With all the threads about pwo nutrition I can see maybe using it to help shuttle carbs/replenish glycogen pwo without using slin. It seems promising to me, it's cheap too. Thanks.

 

[6.8SPC]

?????...

The addition of fenugreek extract (Trigonella foenum-graecum) to glucose feeding increases muscle glycogen resynthesis after exercise.
Ruby BC, Gaskill SE, Slivka D, Harger SG.

Department of Health and Human Performance, The University of Montana, Missoula, Montana 59812-1825, USA. [email protected]

The purpose of this study was to determine the effects of ingesting an oral supplement containing 4-Hydroxyisoleucine (4-OH-Ile, isolated from fenugreek seeds [Trigonella foenum-graecum]) with a glucose beverage on rates of post-exercise muscle glycogen resynthesis in trained male cyclists. Following an overnight fast (12 hr), subjects completed a 90-minute glycogen depletion ride after which a muscle biopsy was obtained from the vastus lateralis. Immediately and 2 hours after the muscle biopsy, subjects ingested either an oral dose of dextrose (Glu) (1.8 g.kg BW(-1)) or 4-OH-Ile supplement (Glu+4-OH-Ile, including 2.0 mg.kg(-1) 4-OH-Ile with the same oral dose of dextrose) with a second muscle biopsy 4 hours after exercise. Post exercise muscle glycogen concentration was similar for both trials. Overall, there was a significant increase in glucose and insulin concentrations from time 0 throughout the majority of the 4-hour recovery period, with no significant differences between the two trials at any time point. Although muscle glycogen concentration significantly increased from immediately post exercise to 4 hr of recovery for both trials, the net rate of muscle glycogen resynthesis was 63% greater during Glu+4-OH-Ile (10.6+/-3.3 vs. 6.5+/-2.6 g.kg wet wt.(-1).hr.(-1) for the Glu+4-OH-Ile and Glu trials, respectively). These data demonstrate that when the fenugreek extract supplement (4-OH-Ile) is added to a high oral dose of dextrose, rates of post-exercise glycogen resynthesis are enhanced above dextrose alone.

PMID: 15719265 [PubMed - indexed for MEDLINE]

 

[6.8SPC]

Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study.

Gupta A, Gupta R, Lal B.
Jaipur Diabetes and Research Centre.

OBJECTIVES: To evaluate the effects of Trigonella foenum-graecum (fenugreek) seeds on glycemic control and insulin resistance, determined by HOMA model, in mild to moderate type 2 diabetes mellitus we performed a double blind placebo controlled study. METHODS: Twenty five newly diagnosed patients with type 2 diabetes (fasting glucose < 200 mg/dl) were randomly divided into two groups. Group I (n=12) received 1 gm/day hydroalcoholic extract of fenugreek seeds and Group II (n=13) received usual care (dietary control, exercise) and placebo capsules for two months. RESULTS: At baseline both the groups were similar in anthropometric and clinical variables. Oral glucose tolerance test, lipid levels, fasting C-peptide, glycosylated haemoglobin, and HOMA-model insulin resistance were also similar at baseline. In group 1 as compared to group 2 at the end of two months, fasting blood glucose (148.3 +/- 44.1 to 119.9 +/- 25 vs. 137.5 +/- 41.1 to 113.0 +/- 36.0) and two hour postglucose blood glucose (210.6 +/- 79.0 to 181.1 +/- 69 vs. 219.9 +/- 41.0 to 241.6 +/- 43) were not different. But area under curve (AUC) of blood glucose (2375 +/- 574 vs 27597 +/- 274) as well as insulin (2492 +/- 2536 vs. 5631 +/- 2428) was significantly lower (p < 0.001). HOMA model derived insulin resistance showed a decrease in percent beta-cell secretion in group 1 as compared to group 2 (86.3 +/- 32 vs. 70.1 +/- 52) and increase in percent insulin sensitivity (112.9 +/- 67 vs 92.2 +/- 57) (p < 0.05). Serum triglycerides decreased and HDL cholesterol increased significantly in group 1 as compared to group 2 (p < 0.05). CONCLUSIONS: Adjunct use of fenugreek seeds improves glycemic control and decreases insulin resistance in mild type-2 diabetic patients. There is also a favourable effect on hypertriglyceridemia.
PMID: 11868855 [PubMed - indexed for MEDLINE]

 

[speedbacker]

I've used it and like it a lot. It will definitely help to keep you lean during times where your carb intake is higher. I use fenugreek with gymnema sylvestre.

 

[6.8SPC]

I've used it and like it a lot. It will definitely help to keep you lean during times where your carb intake is higher. I use fenugreek with gymnema sylvestre.

How do you use it? PWO? with large carb meals?
Gymnema is an ayurvedic herb correct? I've read that it can help stimulate and improve insulin production directly in the pancreas. Thanks for feedback.

 

[speedbacker]

How do you use it? PWO? with large carb meals?
Gymnema is an ayurvedic herb correct? I've read that it can help stimulate and improve insulin production directly in the pancreas. Thanks for feedback.

Yea, I use it, 600mg pwo and also with meals that are larger in carbs. I've also been using USP labs 2 products p-slin and anabolic pump, and have been pleasantly surprised with them, using them for similar reasons as the fenugreek and GS.