Found the answer to Phil's EOD GH Protocol

[dragonfire101]

Clin Endocrinol Metab. 2002 Aug;87(8):3573-7. Related Articles, Links


Prevention of growth deceleration after withdrawal of growth hormone therapy in idiopathic short stature.

Lampit M, Hochberg Z.

Department of Pediatrics, Meyer Children's Hospital, Haifa 31096, Israel.

The treatment of children with idiopathic short stature by daily injections of human GH (hGH) is followed after its withdrawal by a growth deceleration with normal serum GH and IGF-I levels. The present study was designed to understand and prevent growth deceleration. We hypothesized that this phenomenon is due to tolerance at the target organ level, that tolerance develops in response to the unphysiological pharmacokinetics of daily-injected hGH, and that alternate day hGH therapy will prevent it. Thirty-eight prepubertal children with idiopathic short stature, aged 3.3-9.0 yr, were studied. Their heights were less than -2 SD score, growth rate was above the 10th percentile for age, bone age was less than 75% of chronological age, and the stimulated serum GH concentration was greater than 10 microg/liter. The children were matched for sex, height, and growth velocity SD score to receive daily or alternate day hGH at the same weekly dose of 6 mg/m(2) for a period of 2 yr. The 1st and 2nd year mean growth velocities were 3.4 and 2.3 SD score for the daily therapy group and 3.0 and 2.0 SD score for the alternate day group, respectively (P = NS). Over the initial 6 months after withdrawal of therapy, and growth velocity decelerated to a nadir of -3.9 SD score in the daily therapy group, whereas it decelerated in the alternate day group to only -0.2 SD score (P < 0.01). Over the entire 2 yr off therapy the latter group maintained mean growth rates of -0.2 to -1.2 SD score, similar to their pretreatment velocities. The daily group recovered slowly to resume their mean pretreatment rate only on the fourth semiannual evaluation off therapy. The cumulative 4-yr growth velocity (2 yr on and 2 yr off therapy) of the alternate day group was greater than that of the daily therapy group (mean, 0.9 vs. 0.3 SD score; P < 0.002). At the end of the 4-yr therapy period, the adult height prediction of the alternate day group was greater than that of the daily group by a mean 6.5 cm (P = 0.06). It is concluded that growth deceleration after withdrawal of hGH therapy in idiopathic short stature is due to tolerance to GH and IGF-I in response to the unphysiological pharmacokinetics of daily-injected hGH and that alternate day therapy allows for an alternate day physiological GH profile, thus preventing tolerance during therapy and growth deceleration thereafter.

Publication Types:
Clinical Trial
Controlled Clinical Trial

PMID: 12161476 [PubMed - indexed for MEDLINE]

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[Fullybuilt]

Whats this mean in laymens terms?

 

[Steak Helmet]

I have done the ED and the EOD and prefer the EOD way better than the ED.

 

[MAINEVENT]

I have done the ED and the EOD and prefer the EOD way better than the ED.

Steak, do you use the 2 iu's eod?

 

[db006]

2 on 1 off for me

 

[finephysique]

I thought Phils protocol was one huge blast every 2 weeks?

 

[dragonfire101]

I thought Phils protocol was one huge blast every 2 weeks?

Yes, that was his suggestion also and the EOD.

 

[KillerStack]

Regarding the study: BBers are not trying to grow taller, and the target organ is not bone. So what real relevance does it have to those who are trying to get leaner and hopefully put on some muscle? I don't know.

 

[dragonfire101]

So what real relevance does it have to those who are trying to get leaner and hopefully put on some muscle? I don't know.

The study was not posted in regards to how much leaner or bigger a Bodybuilder can get from GH use.


It was posted to show that tolerance develops in response to the unphysiological pharmacokinetics of daily-injected hGH, and that alternate day hGH therapy will prevent it.

So the real relevance for the Bodybuilding is it may be beneficial dosing GH EOD as suggested by some individuals.

Especially if it may be a long GH cycle.

 

[hardkor]

Makes sense. I find there are a lot of bb's that are doing EOD GH but at higher doses than what they were doing ED. Haven't tried it yet myself but after reading this article, I think i'll give it a go. thanks!

 

[dragonfire101]

For entertainment purposes 2-4iu EOD and then do the 24iu blast every 2-3 weeks or maybe just once a month if one wanted to save on GH.

 

[BigBoyJ]

I thought I read somewhere that the body will develop anti-bodies that destroy gh when it's done every day. Using gh eod helps prevent the formation of these anti-bodies. Or maybe I was dreaming that...or I could be mildly retarded.

 

[Fullybuilt]

I would think the only way to prove this is to get IGF bloodwork done during the ED protocol and the same on the EOD protocol?

 

[pickapeck]

Bump.. this has come up recently in another thread and thought this would be a good information.

 

[LK3]

an idea is also to run peptides after.