- Joined
- Jun 19, 2013
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I've been asked more then several times if IGF1 should be combined with GH, and why not to take it by itself or instead of GH usage ?
In a nutshell the ideal solution is using GH in combination with IGF1-lr3 and/or IGF1-DES
It's true that the IGF1 is the mediator for most of the anabolic effect of the GH, but we must consider 2 things -
The GH has some direct metabolic effect by itself, both in releasing glucose and fatty acid into the circulation, and by this raising metabolism and releasing available energy for anabolic demands, The GH has also a direct effect on nitrogen balance not through the IGF1 path
The IGF1 itself has a direct suppressing effect on the endogenous GH release - so if u inject exogenous IGF you actually and directly suppress any GH present in the circulation
Further more - many GH users are not aware to the fact that GH decreases insulin sensitivity. IGF1 increases insulin sensitivity, and negates this effect, which leads to optimal metabolic conditions. Some users use insulin in conjunction with GH but using IGF1 is much more effective in retaining optimum insulin sensitivity and much much safer
So the ideal solution is combining them both and by this keep optimal serum GH and IGF1 levels
In a nutshell the ideal solution is using GH in combination with IGF1-lr3 and/or IGF1-DES
It's true that the IGF1 is the mediator for most of the anabolic effect of the GH, but we must consider 2 things -
The GH has some direct metabolic effect by itself, both in releasing glucose and fatty acid into the circulation, and by this raising metabolism and releasing available energy for anabolic demands, The GH has also a direct effect on nitrogen balance not through the IGF1 path
The IGF1 itself has a direct suppressing effect on the endogenous GH release - so if u inject exogenous IGF you actually and directly suppress any GH present in the circulation
Further more - many GH users are not aware to the fact that GH decreases insulin sensitivity. IGF1 increases insulin sensitivity, and negates this effect, which leads to optimal metabolic conditions. Some users use insulin in conjunction with GH but using IGF1 is much more effective in retaining optimum insulin sensitivity and much much safer
So the ideal solution is combining them both and by this keep optimal serum GH and IGF1 levels