Guys, I have to throw this in too, is you are not putting the supplement Cissus quadrangularis in your daily regimen you are missing out.
1: J Ethnopharmacol. 2007 Mar 21;110(2):264-70. Epub 2006 Sep 26.Click here to read Links
Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn.
Panthong A, Supraditaporn W, Kanjanapothi D, Taesotikul T, Reutrakul V.
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
[email protected]
Cissus quadrangularis, a medicinal plant indigenous to Asia and Africa, is used for many ailments, especially for the treatment of hemorrhoid. The effects associated with hemorrhoid, i.e. analgesic and anti-inflammatory activities as well as the venotonic effect of the methanol extract of C. quadrangularis (CQ) were assessed in comparison with reference drugs. In the analgesic test, CQ provoked a significant reduction of the number of writhes in acetic acid-induced writhing response in mice. CQ also significantly reduced the licking time in both phases of the formalin test. The results suggest peripheral and central analgesic activity of CQ. In acute phase of inflammation CQ elicited the inhibitory effect on the edema formation of the rats' ear induced by ethyl phenylpropiolate as well as on the formation of the paw edema in rats induced by both carrageenin and arachidonic acid. It is likely that CQ is a dual inhibitor of arachidonic acid metabolism. In addition, CQ exerted venotonic effect on isolated human umbilical vein similarly to the mixture of bioflavonoids, i.e. 90% diosmin and 10% hesperidin.
The results obtained confirmed the traditional use of C. quadrangularis for the treatment of pain and inflammation associated with hemorrhoid as well as reducing the size of hemorrhoids.
RESEARCH PAPER
Year : 1984 | Volume : 16 | Issue : 3 | Page : 162-163
An experimental study of analgesic activity of Cissus quadrangularis
SP Singh, N Misra, KS Dixit, N Singh, RP Kohli
1. The analgesic activity of alcoholic extract of whole plant of cissus quadrangularis family vitaceae), was studied in mice by Haffner's Clip and Eddy's hot plate methods. 2. The extract effective by both oral and i.p. routes significantly (P < 0.001) increased the reaction time by both methods. 3. The duration of analgesic activity was from 2 to 4 h and optimum effect was observed at l/20th -1/10th of LD50 dose. The extract compared well with acetylsalicylic acid.
Conclusion:
The analgesic effect of this plant when used in bone fractures
may be of great value in relief of pain which is a constant feature in these cases. As
it compared well with acetyi salicylicacid initsanalgesic response the nature of its chemically active constituents needs to be explored.
Other good things it can do:
The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome
Julius Oben1 email, Dieudonne Kuate1 email, Gabriel Agbor1,2 email, Claudia Momo1 email and Xavio Talla1
Abstract
Aim
Once considered a problem of developed countries, obesity and obesity-related complications (such as metabolic syndrome) are rapidly spreading around the globe. The purpose of the present study was to investigate the use of a Cissus quadrangularis formulation in the management of metabolic syndrome, particularly weight loss and central obesity.
Methods
The study was a randomized, double-blind, placebo-controlled design involving 123 overweight and obese persons (47.2% male; 52.8% female; ages 19–50). The 92 obese (BMI >30) participants were randomized into three groups; placebo, formulation/no diet, and formulation/diet (2100–2200 calories/day). The 31 overweight participants (BMI = 25–29) formed a fourth (no diet) treatment group. All participants received two daily doses of the formulation or placebo and remained on a normal or calorie-controlled diet for 8 weeks.
Results
At the end of the trial period, statistically significant net reductions in weight and central obesity, as well as in fasting blood glucose, total cholesterol, LDL-cholesterol, triglycerides, and C-reactive protein were observed in participants who received the formulation, regardless of diet.
Conclusion
Cissus quadrangularis formulation appears to be useful in the management of weight loss and metabolic syndrome.
Cissus
Along with AlbumaSoy, Cissus (CQR-300), a standardized, patented extract of the Cissus quadrangularis plant--is a key ingredient in Soy Labs' CardioTrim line of products.
Cissus quadrangularis causes less amount of tissue reaction in the fractured region leading to optimum decalcification in the early stage with minimum of callus formation. Hence deposition of calcium is just enough to join the two broken segments of bone so that it’s remodeling takes much faster. This early completion of calcification process and earlier remodeling phenomenon lead to early recovery of Cissus treated animals.
Cissus is also shown to cause early gain in the tensile strength of fractured bones of about 90 per cent of its normal strength at the end of 6 week.
Cissus quadrangularis builds up the chemical composition of the fractured bone namely its mucopolysaccharides, collagen, calcium, phosphorus and others as well as its functional efficiency.
Mucopolysaccharides are a key component of the foundation of connective tissue. In addition, they provide a matrix upon which collagen, the major structural protein of ligaments and tendons, is built. Mucopolysaccharides also add elasticity and resiliency to skin and other connective tissues.
Mucopolysaccharides also play an important role in the healing by supplying raw materials for repairs. Rapid the utilization of these raw materials earlier will be completion of healing process. Cissus quadrangularis causes greater accumulation of mucopolysaccharides.
Cissus quadrangularis is shown to neutralize the anti-anabolic effect of steroids like cortisone in healing of fractures. Anti-anabolic effects of cortisone include inhibition of tissue regeneration and repair, also retarding formation of the specific skeletal structures. In such conditions even if the cartilage tissue is produced, its maturation and ultimate bone replacement do not take place in the normal pattern. It has main inhibitory action on fibroblasts and mast cells, which produce mucopolysaccharides of connective tissue. There have been reports that continuous intake of corticosteroids induces osteoporosis and pseudo fractures in the bone.
Imbalance in the activities of osteoclasts (cells responsible for bone loss) and osteoblasts (cells responsible for bone formation) may lead to osteoporosis and fractures in postmenopausal women. In osteoporosis, the bones begin to deteriorate due to calcium deficiency as a result of the body's efficiency in maintaining mineral balance in the blood at the expense of bone integrity. During menopause the decrease in hormones affects the body's ability to maintain calcium levels resulting in an increased loss of minerals from the bones. Postmenopausal women are at particular risk to osteoporosis because the loss of estrogen associated with the menopause leads to bone loss of much greater magnitude than one would expect on the basis of age alone. Cissus quadrangularis with significant ability to inhibit anti-anabolic effects and bone fracture healing effects is likely to exert some beneficial effects on recovery of bone mineral density in postmenopausal osteoporosis.
I wondering if a cortizone shot in each shoulder to get rid of the inflamation while taking the GHRP for collagen synthisis would be the best option. Anyone have any feedback?
If you are looking for a quick solution to the problem, cortizone is your best bet. However, after the cortizone I would take some proactive measures to help prevent it from coming back. The above is a good long term solution.
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