Gh
exogenous use of human growth hormone will increase the release of insulin like growth factor-1, which can bind to the insulin receptor. Prolonged use of exo HGH can lead to insulin resistance, which will diminish the effectiveness of insulin in antagonizing the release of glucagon from the alpha cells of the pancreas. This can lead to increased hepatic gluconeogensis, as well as (in severe prolonged use) non alcohol related fatty liver disease.