I've been confused about that study, and the claims that it was using 100x a human dose. We say that 5mg/kg/day for a rat means 400-500mg total for a human, but I thought you had to consider body surface area and metabolism? Per Ergo Log at Found an interesting animal study? Here's how you calculate the human dosage I understand the formula to be:
Human dose = Animal dose x Animal Km/Human Km
So to take the 5mg/kg/day dose I interpret that as:
5mg x (6 Rat/37 Human) = 0.81mg/kg/day
Wich for me at 92kg = 92 x 0.81 = 75mg
Which is quite a bit closer to what we dose.
Do I misunderstand?
- T (Admittedly bad at math)
Human dose = Animal dose x Animal Km/Human Km
So to take the 5mg/kg/day dose I interpret that as:
5mg x (6 Rat/37 Human) = 0.81mg/kg/day
Wich for me at 92kg = 92 x 0.81 = 75mg
Which is quite a bit closer to what we dose.
Do I misunderstand?
- T (Admittedly bad at math)