How does GH *cause* fat loss?

[JW]

It seems most studies and literature state GH causes significant fat loss However, the never seem to explain how GH causes fat loss. What is the mechanism? With all the new peptides out GH is still the contest prep favorite for re comp and or fat loss is this warranted or just old school thinking?

 

[Putin]

I wouldnt call it SIGNIFICANT. Maybe it's dose dependtant.

 

[vadim_b1]

Through nutrient partitioning i think. Meaning muscle cells get the nutrients, fat cells do not, and hence shrink. Only a speculation though.

 

[mikeheavypecs]

I am on my 3rd week of GH. My pulse has been about 10 points higher the past couple of weeks, even when I get up in the middle of the night. I have guessed that the increase pulse rate burns alot of fat. I am amazed already how my abs are getting sharper.

Mike

 

[cobra333]

same here pulse is definantley higher ... and a woody that wont go down in the morning ... lolllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllll

 

[The_Beast]

hGH increases the release of fatty acids from the adipocytes (fat cells) into the blood stream which makes it easier to burn for energy. So in essence hGH increases the amount of fat being burned for energy by making this process easier.

Here is a chart from Snyder et al. (1990) comparing the amount of fatty acids released between 0.1mg of hGH per kg of lean body weight and a saline vehicle only (saline water, no GH).

Wiborg et al. (2000) also concluded that hGH therapy enhanced the efficacy of the oxidative metabolism... meaning that the muscles become better at utilizing fat for fuel, which would help lose fat AND preserve glycogen levels.

Ottosson et al. (1995) also found that hGH inhibits lypoprotein lipase (LPL) which would reduce the capacity of the body to store fat.

Finally we can also consider the IGF-1 increase from hGH use which would increase nutrients storage in the muscle (thus reducing storage in fat cells). It would also stimulate muscle growth which would indirectly increase fat burning via an increase in metabolic rate.

 

[JW]

thanks, thats what I was looking for....

 

[The_Beast]

thanks, thats what I wa slooking for....

I'm editing my post as we speak as I review the literature I have saved on my disk.

 

[The_Beast]

I wouldnt call it SIGNIFICANT. Maybe it's dose dependtant.

Actually it isn't ... I have a study stored somewhere (currently looking for it) and the effect on fatty acid mobilization isn't significantly dose-dependant ... however the IGF-1 stimulating properties of hGH ARE dose-dependant... which would indicate that for fat loss a lower, more frequent dose regimen might be best while for growth infrequent but large doses would be better.

 

[The_Beast]

Here it is... don't remember the exact doses, but the highest one was pretty high, the equivalent of around 20IU for a 200lbs guy and the lowest one being around 1IU.

 

[Smiler51]

Great Post!!!

I was always wondering the same myself. Thanks for answering and the graphs.

 

[mikeheavypecs]

same here pulse is definantley higher ... and a woody that wont go down in the morning ... lolllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllll

same here about the pulse AND WOODY. I can wake up with one, walk around the house, talk on the phone, watch the morning news and it is still UP
LOL

Mike

 

[mikeheavypecs]

Beast,
YOu obviously know your stuff........why is my pulse around 10 points higher since I started GH? I can even wake up at night and it is 91 (would used to be in the very low 80's) even at 3am...day time used to be in low 91s and now it can be 101 even at work and not working out.....just curious what causes that. Thyroid speeded up by GH???

Thanks!
Mike

hGH increases the release of fatty acids from the adipocytes (fat cells) into the blood stream which makes it easier to burn for energy. So in essence hGH increases the amount of fat being burned for energy by making this process easier.

Here is a chart from Snyder et al. (1990) comparing the amount of fatty acids released between 0.1mg of hGH per kg of lean body weight and a saline vehicle only (saline water, no GH).

Wiborg et al. (2000) also concluded that hGH therapy enhanced the efficacy of the oxidative metabolism... meaning that the muscles become better at utilizing fat for fuel, which would help lose fat AND preserve glycogen levels.

Ottosson et al. (1995) also found that hGH inhibits lypoprotein lipase (LPL) which would reduce the capacity of the body to store fat.

Finally we can also consider the IGF-1 increase from hGH use which would increase nutrients storage in the muscle (thus reducing storage in fat cells). It would also stimulate muscle growth which would indirectly increase fat burning via an increase in metabolic rate.

 

[KillerStack]

Here it is... don't remember the exact doses, but the highest one was pretty high, the equivalent of around 20IU for a 200lbs guy and the lowest one being around 1IU.

Can you find the full study? From my recollection IGF-1 increase was only dose dependent up to about 7IU.

Edit, here's a snip from a post by Karl Hoffman on another forum:

http://jcem.endojournals.org/cgi/content/full/85/11/4193

They dosed in IU/kg, so if you use the value of 70 kg for the average male, then there is no difference in this study in terms of IGF-1 between 7 IU/day and 14 IU/day. In women the story is quite different, as can be seen in fig1.

What about doses less than 7 IU per day? I've looked around many times and have never seen one study that answers that question. You can kind of piece together an answer by comparing the study above with this one:
http://ajpendo.physiology.org/cgi/content/full/276/6/E1009

Here IGF-1 increased as they increased the GH dose up to 4.2 IU per day. Unfortunately that was the maximum GH dose used.

So one can conclude that IGF-1 maxes out somewhere between around 4 and 7 IU per day.

 

[The_Beast]

Beast,
YOu obviously know your stuff........why is my pulse around 10 points higher since I started GH? I can even wake up at night and it is 91 (would used to be in the very low 80's) even at 3am...day time used to be in low 91s and now it can be 101 even at work and not working out.....just curious what causes that. Thyroid speeded up by GH???

Thanks!
Mike

We can rule out thyroid since hGH can lead to a reduction in T4 and T3 levels (which is why it's best to use thyroid medication during extended hGH use ...). hGH can increase serum sodium levels (Graham et al. 2007) which would lead to water retention which can in turn lead to increased blood pressure. The increase in blood pressure might put more strain on the heart because it will have to work harder to "push" the blood through the vascular system (because of the increase in blood pressure, especially when AAS are also used).

The added workload can either be accomplished by having the heart produce a stronger push (stronger myocardial contraction ... the heart is a muscle and if it's strong enough it can contract harder) or more frequent pushes (increased heart rate).

Boguer et al. (1996) have shown that hGH use lead to an increase in cardiac output of 30-40%, mostly because of an increase in nitric oxide production which leads to an increase in vasodilatation.

However this effect (increased blood pressure) is speculative since a lot of studies on hGH tend to show a decrease in blood pressure and some even show a decrease in resting heart rate (Sverrisdottir et al. 2003).

hGH seems to reduce the excretion of adrenaline, which might mean that it makes drugs like clenbuterol, ephedrine and albuterol more effective to... it is worth considering that the heart rate increase comes from a combination of several products, not only from the hGH itself.

 

[A50#]

I am on my 3rd week of GH. My pulse has been about 10 points higher the past couple of weeks, even when I get up in the middle of the night. I have guessed that the increase pulse rate burns alot of fat. I am amazed already how my abs are getting sharper.

Mike

Same here Mike. After about 4 week into it on 4iu/day I noticed my entire mid section tightened up.

 

[mikeheavypecs]

Beast, I am also on 900mg/week of test Enan and 600mg/wk of Deca...maybe that in conjuction with GH is causing the pulse to increase......

thanks for your reply!
Mike

We can rule out thyroid since hGH can lead to a reduction in T4 and T3 levels (which is why it's best to use thyroid medication during extended hGH use ...). hGH can increase serum sodium levels (Graham et al. 2007) which would lead to water retention which can in turn lead to increased blood pressure. The increase in blood pressure might put more strain on the heart because it will have to work harder to "push" the blood through the vascular system (because of the increase in blood pressure, especially when AAS are also used).

The added workload can either be accomplished by having the heart produce a stronger push (stronger myocardial contraction ... the heart is a muscle and if it's strong enough it can contract harder) or more frequent pushes (increased heart rate).

Boguer et al. (1996) have shown that hGH use lead to an increase in cardiac output of 30-40%, mostly because of an increase in nitric oxide production which leads to an increase in vasodilatation.

However this effect (increased blood pressure) is speculative since a lot of studies on hGH tend to show a decrease in blood pressure and some even show a decrease in resting heart rate (Sverrisdottir et al. 2003).

hGH seems to reduce the excretion of adrenaline, which might mean that it makes drugs like clenbuterol, ephedrine and albuterol more effective to... it is worth considering that the heart rate increase comes from a combination of several products, not only from the hGH itself.

 

[mikeheavypecs]

A50, yeh its kinda cool to watch your entire midsection change. I just started into my 4th week and others have made many comments to that affect.....

Mike

Same here Mike. After about 4 week into it on 4iu/day I noticed my entire mid section tightened up.