IMO, controlling serum Myo levels via increased Follistatin, Myo Propeptide, various GDF-8 antibodies, is transitory at best, without consideration of the degree of what the total end result may be from the dosages used.
My point is that once homeostasis returns myo serum levels back to normal, unless you are on some other cycle or adequate hrt lifestyle, your results will not be mainained. You would need to be on a permanent replacement therapy of these compounds per se, unless you opt for the viral vector route using DNA/RNA gene scilencing.
This is the reason most are interested in duplication the mechanisms involved in Myo DNA mutations (Myo Gene deficiencies). Black747 has used more myo related compounds than anyone else I know.
He started years back with custom anti GDF-8 antibodies, then a pegylated version of the same antibody for similar systemic control of Myo levels.
He moved on eventually to hush 29mer Myo shRNA which was also futile.
He was not using the efficacy of viral vectors used in studies, relying more on other transfection regeants for the custom plasmid constructs. It was trial and error.
He is currently working on more research into other regeants and plans to keep trying to find the "magic bullet" in this area of interest to him.
Anyhow I digress, and just wanted to point out that IMO, systemic control of serum Myo is not worth the price, especially since this can already be achieved via AAS. I am not even discussing the potential health negatives of Myo alteration either.
So, for someone as dedicated to this as Black747 is, going the gene silencing route is a more fruitful direction. Reduction in Myo needs to be drastic and needs to be long term. I mean loooong, like typical growth factors require before manifestation of disernible results are realized. The kind of levels/duration in myo deficiency observed for years during ones growth phase, or years one might need to have myo silenced via gene therapy.
10 days or 100 days or even one year would not be worth the price of "continual use" method for this area IMO. But if you have ALL the money in the world, this may be a different viewpoint as well.
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