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OSTARINE the new SARMS

Osta-gain

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LOOK AT THESE STUDIES ....WOW

Clinical development (GTx, Inc.)

OstarineTM is an aryl propionamide SARM and the most advanced clinical candidate. OstarineTM demonstrated exciting data in an initial proof-of-concept Phase IIa clinical trial. GTx, Inc. reported in December 2006 the results of this clinical trial, which was a double blind, randomized, placebo-controlled trial in sixty elderly men and sixty postmenopausal women [Dalton, 2007a; Dalton, 2007b]. Without a prescribed diet or exercise regimen, all subjects treated with OstarineTM had a dose-dependent increase in total LBM, with the 3 mg/day cohort achieving an increase of 1.3 kg compared to baseline and 1.4 kg compared to placebo after 3 months of treatment. Treatment with OstarineTM also resulted in a dose-dependent improvement in functional performance measured by a stair climb test, with the 3 mg/day cohort achieving clinically significant improvement in speed and power. Interestingly, subjects treated with 3 mg/d of OstarineTM had on average an 11% decline in fasting blood glucose, a 17% reduction in insulin levels, and a 27% reduction in insulin resistance (homeostasis model assessment) as compared to baseline, suggesting that sarms might have therapeutic potential in diabetics or people at risk for diabetes. Phase I clinical studies with OstarineTM showed that it was rapidly absorbed after oral administration with a half-life of about 1 day (unpublished data).
 

Osta-gain

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GTx Announces Ostarine Increased Lean Body Mass and Leg Press Strength in Head to Head Clinical Study

SAN DIEGO, Jun 21, 2010 (BUSINESS WIRE) -- GTx, Inc. /quotes/comstock/15*!gtxi/quotes/nls/gtxi (GTXI 3.00, -0.01, -0.33%) announced that Ostarine(TM) (GTx-024, formerly MK-2866) increased lean body mass and leg press strength in a head to head study evaluating Ostarine and another selective androgen receptor modulator (SARM), MK-3984, in postmenopausal women. The data were presented yesterday at the 2010 Annual Meeting of the Endocrine Society. GTx is developing its lead SARM, Ostarine, for the treatment of cancer induced muscle wasting (cancer cachexia).

"This is the third Ostarine clinical study that measured lean body mass and physical performance endpoints, and Ostarine has consistently demonstrated the ability to increase muscle mass and strength," said Mitchell S. Steiner, MD, CEO of GTx. "We also continue to be pleased with Ostarine's safety profile."

The 12 week, randomized clinical trial evaluated Ostarine 3 mg and two doses of MK-3984 compared to placebo in 88 postmenopausal women. Total lean body mass was measured by DEXA at baseline and 12 weeks, and physical performance was evaluated at the same interval by bilateral leg press machine.

After 12 weeks of treatment, Ostarine 3 mg and MK-3984 significantly increased total lean body mass. Compared to placebo, mean differences from baseline for lean body mass were observed with increases of 1.54 kg (p value<0.001) for both Ostarine 3 mg and 50 mg of MK-3984 and an increase of 1.74 kg (p value<0.001) for 125 mg of MK-3984. Increases in thigh muscle volume as measured by MRI for Ostarine and MK-3984 were noted as early as week 4 with the effect persisting through the end of the study. Ostarine 3 mg and MK-3984 treatment resulted in an increase in leg muscle strength. Mean leg muscle strength at 12 weeks for Ostarine 3 mg treated subjects increased by 22 pounds from baseline.

Ostarine 3 mg and MK-3984 were tissue selective. Treatment did not cause virilization in these women, as there was no change in sebaceous gland volume, rate of sebum excretion, or hair follicle gene expression. Moreover, Ostarine 3 mg and MK-3984 did not stimulate endometrial proliferation as measured by endometrial thickness. As for safety, seven subjects treated with MK-3984 were discontinued from the study due to elevations in Liver enzymes greater than three times the upper limit of normal, whereas no clinically significant Liver enzyme elevations occurred in subjects treated with Ostarine.

In summary, 12 week treatment with Ostarine 3 mg and MK-3984 had comparable efficacy on total lean body mass, muscle strength and tissue selectivity in postmenopausal women. Ostarine 3 mg was well tolerated with no clinically significant Liver enzyme elevations.


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J_Diggs

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Jun 1, 2010
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Very nice research to support the product. The initial test stated it was an oral administration. Do you know if that is the most effacious method of delivery for the animals subjects they are tested on? Thanks for any insight here and I am interested in the product. I will look into it further and may reach out to you again.
 

Osta-gain

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Very nice research to support the product. The initial test stated it was an oral administration. Do you know if that is the most effacious method of delivery for the animals subjects they are tested on? Thanks for any insight here and I am interested in the product. I will look into it further and may reach out to you again.
I'm unaware of a injectable source for ostarine.. Oral seems to work great and if its not broke then why fix it?
 

EDED

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Jan 31, 2009
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i guess these bastards dont have aging parents ahahhahahah no replies lol

there is no way in hell they would do GH injections,

postmenopausal mother has all the symptoms of low energy, she takes bone medicine ( no not viagra ahahha), cholesterol etc

father is getting smaller and more feeble, prostate issue <<<no worries here though.

anyways, I have old lab mice too, so Osta should be interesting in the mice,,,,i will give my parents some ginseng tea instead ;)
 

EDED

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Jan 31, 2009
Messages
987
also 3 mg per day, one day half life? amazing.
 

minister

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I would love to put my dog on it , but you need a small fortune.
 

EDED

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Messages
987
^^^ dose dependent though ;)

old mice will get 3mg

young dumb full of c** mice will be on 25er
 

minister

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Get it while its on sale and run it at 15mg a day for your test subject... that will last for 60 days...and your subject will still get great gains
I think I will jump on that. Thanks and Blesiings friends> Minister.
 

Tom

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interested in sale, is there a link?
 

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