©ALL CONTENT OF THIS WEBSITE IS COPYRIGHTED AND CANNOT BE REPRODUCED WITHOUT THE ADMINISTRATORS CONSENT 2002-2024
.gif "IP Gear")
Provigil
- Thread starter Ashop
- Start date
E
edge250
Guest
i have a script from my sleep apnea. 100-200mg is plenty, very alert yet no jitters like ephedrine. usually lasts about 10-12 hours. i have what the docs call "shift workers syndrome" this stuff helps tremendously. i only use it on work days. i do not feel it enhances focus in the gym or anything or gives you any boost other than being awake. use it sparingly.
- Joined
- May 19, 2004
- Messages
- 5,196
I have read that it doesn't cause insomnia, that you can go to sleep with the drug in your system. True?edge250 said:
Most of my patients like this but the cost is outrageous. many insurance providers do not provide good coverage for this.
I have tried 100mg in the am and at noon. Was I impressed ... well not for the cost, i think the OTC caffeine stimulants work just as well, but the problem is ensuring safety with them.
I have tried 100mg in the am and at noon. Was I impressed ... well not for the cost, i think the OTC caffeine stimulants work just as well, but the problem is ensuring safety with them.
E
edge250
Guest
KillerStack said:
true.
- Joined
- Oct 9, 2003
- Messages
- 1,044
I have used it for the mental focus pc. and it did nothing for me at all. I took upto 300mg a day. I read somewhere it does not work for everyone. I did not see any diffrence at all in the gym or sleeping. I travel almost 90% of my week and to different time zones each week and it has not helped me at all.
I Like it
I have been useing Provigil for about 2 years now. I have sleep apnea and was always dragging ass. There is no jittery feeling. I have been juicing since 1977 and I have not been off since 1995. It does not interact with anything else that I know of. You dont even know its in your system, you are just not tired. There is no jacked feeling. You can sleep while taking this if you like. I take 200mg once every day. If I dont take it, I drag ass. My insurance gives me a 30 day supply for $30.
I have been useing Provigil for about 2 years now. I have sleep apnea and was always dragging ass. There is no jittery feeling. I have been juicing since 1977 and I have not been off since 1995. It does not interact with anything else that I know of. You dont even know its in your system, you are just not tired. There is no jacked feeling. You can sleep while taking this if you like. I take 200mg once every day. If I dont take it, I drag ass. My insurance gives me a 30 day supply for $30.
- Joined
- May 25, 2006
- Messages
- 216
KillerStack said:
I've found that sleep suffers if I dose after noon. SO it is a very long-lasting drug (helf-life).
- Joined
- May 25, 2006
- Messages
- 216
I've been munching on some bulk powder I got from a site sponsor in July. The effect was amazing at first, but I developed a tolerance. I have not noticed a crash effect.
This drug looks good for addiction, memory loss, depression, ...
This drug looks good for addiction, memory loss, depression, ...
- Joined
- Dec 8, 2004
- Messages
- 992
I did alot of research on this in the past.. Used it with good results. I would be carefull using it with any antidepressants.
there's tons of info on it. our own sponser Bodies by Design carries it at a great price.
you can get alot of info at www.antiaging-systems.com (not a plug Mods, but feel free to edit if need be)
Here's an article I pulled:
Modafinil, The Unique Stimulant?
By Robert Mason PhD
Modafinil is an eugeroic drug, (which simply means "good arousal"). This unique class contains only two at present, adrafinil and modafinil, both of which have been developed by Lafon Laboratories of France. Currently, their use and effectiveness is little known outside of Europe.
The basis of their uniqueness lies in their ability to only "stimulate when stimulation is required." As a result the "highs and lows" associated with other stimulants such as amphetamine are absent with eugeroics.
Their initial use often produces comments such as "I can't tell any difference." But it is only several hours later when one realizes that attention and awakeness are the same as earlier, that one is aware of their benefit.
Eugeroics have been designed to treat narcolepsy (sleeping in the day), hypersomnia (excessive sleep) and catoplexy (a condition of sudden muscular weakness or fatigue). Yet eugeroics don't affect normal sleep patterns nor are they addictive and they have far fewer side effects than the current prescribed stimulants.
Modafinil its eugeroic action
One study (5) on rats suggested that one possible vigilance enhancing property of modafinil was its ability to inhibit the release of GABA, through an action on 5HTP serotonin receptors. However, the doses used were far higher than normal therapeutic doses.
Meanwhile, most clinical studies point to modafinil as a unique and highly selective agonist of brain postsynaptic receptor sites called, alpha-1 adrenergic (1,2,7,8,9,10).
These sites are receptive to the neurotransmitter- Norepinephrine (NE). The central function of NE is a fairly recent discovery, it appears to regulate alertness and the waking- sleep cycle and has a role in the maintenance of attention, memory, learning, cerebral plasticity and even has neuro-protection qualities (2).
Central nervous stimulants (CNS) such as amphetamine or pemoline are the most widely used drugs to treat narcolepsy, hypersomnia and catoplexy, but these have a number of well documented problems, such as cardiovascular side effects, interference with sleep, psychiatric disturbances and addition.
Two studies (3,10) directly compared the affects of modafinil and d-amphetamine on sleep. Both double blind controls involved about twelve individuals, one study was undertaken on individuals whose mean age were 68, the other on much younger volunteers.
They utilized 100mg or 200mg of modafinil, or 10mg or 20mg of d-amphetamine or a placebo. All the drugs were administered orally and sleep scales, awakening quality and psychometric tests were completed in the morning.
The outcome of both tests showed that d-amphetamine caused a dose dependant impairment of sleep maintenance, but modafinil did not.
Herein lies the problem for those who have difficulty staying alert and awake during the day. The use of "classic" stimulants such as amphetamines threaten to reduce total sleep time and REM sleep, this will ultimately mean higher and higher doses are required and thus creates a vicious circle.
On the other hand, modafinil has not been shown to interfere with nighttime sleep, thus clearly indicating that the two compounds operate by different methods.
Modafinil its studies and clinical trials
Numerous studies on animals since the mid-1980's have confirmed the ability of modafinil to increase awakeness and alertness without serious side effects, or dependency.
One test on rats (4) produced an interesting result. The researchers discovered that modafinil decreased feeding and reduced body-weight! The amounts of modafinil required were not dose dependent and there was no alteration in the drink- feed ratio. Their conclusion was a reference to the possible mechanisms that underlie the relation between sleep, feeding and metabolism.
Various human trials have concentrated upon modafinil as a therapeutic agent to help maintain alertness and vigilance. A note worthy conclusion of one clinical trial (10) compared modafinil to amphetamine and described amphetamine as "vigilance increasing" but modafinil as "vigilance promoting." This is an interesting comment because as we've seen, modafinil won't prevent a person from sleeping if they want to, but if they wish to remain awake they will do so with a far greater alertness.
This was borne out in one clinical trial (11) where volunteers were subjected to 60 hours of sleep deprivation! During their continued wakefulness, their vigilance was assessed using questionnaires, analogue visual scales and sleep latency tests.
The subjects received either 200mg modafinil or a placebo every 8 hours. The modafinil group sustained a satisfactory level of vigilance with an absence of sleep episodes, unlike the placebo group who gradually declined and slipped into "micro-sleep" episodes, (as one might expect when awake for longer than 24 hours!)
A French study (9) conducted over 3 years, discovered that modafinil reduced drowsiness in 83% of hypersomniac patients and 71% of narcoleptics. Modafinil did not produce peripheric side effects, disturb night sleep and it was never responsible for drug dependence.
Another French study conducted with 149 patients over a period of 2 years (13), was treating patients with narcolepsy-cataplexy at 200mg to 400mg daily. The patients were then asked to score the benefit of modafinil themselves from 0 (no affect) to 3 (excellent affect), 64.1% of the subjects scored it as excellent.
An earlier study (17) with 123 patients, which also included those suffering with hypersomnia, physicians evaluated the patients on a scale of 1 (no affect) to 4 (excellent affect). The results? 17% excellent response, 63% good response, 17% fair and 3% no affect. The incidence of side effects were minimal (14 of the 123 patients had side effects, 11 of whose side effects disappeared when doses were reduced).
These results have been repeated in a number of smaller clinical trials (8, 12, 14, and 15) and confirm modafinil's excellent response to treating individuals suffering with narcolepsy, hypersomnia and catoplexy. Its efficacious use in conjunction with a virtual absence of side effects, non contraindication with normal sleep patterns and lack of drug dependence, certainly indicates that eugeroics are a breed apart from conventional stimulants.
Modafinil the military angle
It is fascinating to see that several countries armed forces have studied (and use!) modafinil for military operations. The use of stimulants to keep troops awake and alert is not a new one. It is known that British troops used them during the Falklands conflict and that USAF aircrews took amphetamines during the Libyan air strikes.
More recently the French government admitted that its crack Corp- the Foreign Legion- used modafinil during covert operations inside Iraq during the Gulf war.
In fact, Professor Michel Jouvet, an authority on sleep, claimed during an international defense meeting in Paris that, "modafinil could keep an army on its feet and fighting for three days and nights with no major side effects."
Not surprisingly then, we have heard that modafinil is in use in some sections of the Belgian, Dutch and US airforces.
Modafinil doses, contraindications and side effects
Side effects in 3 years continuous studies of modafinil have been minimal and usually noted as nothing more than headache or nausea, at therapeutic dosages (17, 18).
In rare cases there has been hyper-salivation (19) and moderate tachycardia (increased pulse rate- 20), this probably accounts for modafinil's instruction sheet, which states that those suffering from a heart condition must consult their physician before use. However, blood and pulse rates usually remain unchanged at normal therapeutic doses.
In fact, a suicidal 21-year-old female who ingested 4500mg demonstrated the relative safety of modafinil. Her side effects were limited to tachycardia, excitation and insomnia (9). As is common with most drugs, modafinil should not be used by those with serious liver disorders, or women who are pregnant or nursing.
The official insert for the modafinil package remains unclear as to the precise drug contraindications, but as it is an alpha-adrenergic agonist, those drugs that represent alpha-adrenergic antagonists should be avoided. These include prazosin, phentolamine or beta-blockers such as propranolol (Inderal).
Furthermore, drugs that enhance norepinephrine activity (such as Yohimbine) should only be used with care, as there may be a synergistic affect.
Adrafinil is noted as contraindicated with epilepsy and has been shown to enhance the potency of anti-epileptic drugs such as phenytoin (Dilantin/ Epanutin). Although this isn't mentioned in any of the modafinil literature we have read, it is best being advised of.
As for dosages, there seems to be little difference in doses and more importance placed upon regular administration (12). Those who simply wish to remain awake and alert will benefit from a single 100mg dose. To remain "on-call" all day, 100mg in the morning and another 100mg in the afternoon is probably all that is required. For those wishing to remain awake during the night, then another 100mg in the late evening (in other words approximately every 8 hours).
Dosages for those suffering from narcolepsy, hypersomnia and catoplexy are 100-200mg morning and afternoon. Some of the doses in trials have been as high as 600mg to 700mg daily (9) although doses over 500mg daily may cause euphoria, slight motor excitation or even insomnia!
Modafinil a comparison with Adrafinil
At first glance there may appear to be little difference between the two. It is true that modafinil is more potent, "average" doses of adrafinil are in the region of 600mg to 1200mg daily, compared to modafinil's 200mg to 400mg daily and this is self evident by the respective tablet sizes.
However, if one were to compare adrafinil and modafinil on price alone then adrafinil would win hands down! So the question must be asked, why did Lafon produce a newer analogue of adrafinil?
The answer probably lies in two parts. Firstly, it is thought that adrafinil may not be such a highly selective alpha-1 adrenergic as originally thought and may also affect other alpha receptors, (albeit in a minute fashion).
Secondly, adrafinil is attributed to some other possible side effects that have not been associated (to date) with modafinil, including, stomach pain, skin irritations, inner tension and in long term use (over 3 months usually), an increase in liver enzyme levels, (which is reversible by reduction or withdrawal).
It is our guess that it is this last potential side effect that lead to the development of modafinil. Clearly adrafinil requires regular blood testing to monitor liver enzyme levels and this may prove inconvenient, to those patients who would need to use eugeroics on a regular basis.
As none of the clinical reports we have read indicate any such problem with modafinil, it would appear that the analogue has achieved its desired aim.
Modafinil the conclusion
We were going to reiterate and condense the above article into a few lines, but the conclusion of the Aerospace Medical Association article (16) on modafinil was so good we will leave the last words to them.
"The development of modafinil brings to light a crucial social question. What would be the impediment for its use, if a compound such as modafinil is more like caffeine than amphetamine in terms of safety, and yet, as effective as the amphetamines?"
Our answer? Only time will tell (although looking around the so-called civilized world and seeing the rapid disappearance of individual rights through centralized bureaucratic control, we wouldn't bet on it! -ed.). These are changing and challenging times indeed.
References
1. Lamberg L "Narcolepsy researchers barking up the right tree" JAMA Sep. 96, 11 276 (10) 765-766.
2. Jouvet M, Albarede JL, Lubin S, Meyrignac C "noradrenaline and cerebral aging" Encephale May 1991 17 (3) 187-195.
3. Saletu B, Frey R, Krupka M, Anderer P, Grunberger J, Barbanoj MJ "Differential effects of a new central adrenergic agonist- modafinil and d-amphetamine on sleep and early morning behaviour in elderly" Arzneimittelforschung Oct 1989 39 (10) 1268-73.
4. Nicoladis S, DeSaint, Hilarre Z "Nonamphetamine awakening agent modafinil induces feeding changes in the rat" Brain Res Bull 1993 (32) 2 87-90.
5. Ferraro L, Tanganelli S, O'Connor WT, Antonelli T, Rambert F, Fuxe K "The vigilance promoting drug modafinil decreases GABA release in the medial preoptic area and in the posterior hypothalamus of the awake rate; possible involvement of the serotonergic 5-HT3 receptor" Neuro Sci Lett 1996 Dec 6 220 (1)
6. Gold LH, Balster RL, "Evaluation of the cocaine like discriminative stimulus effects and reinforcing effects of modafinil" Dept of Phar & Tox, Med Coll VA, USA.
7. Maffont F, Mayer G, Minz M, "Modafinil in diurnal sleepiness, a study of 123 patients" Expl Fonct Neuro CHU Parid France. Sleep 1994 Dec 17 (8) 5113-115.
8. Billiard M, Besset A, Montplasir J, Laffont F, Goldenberg F, Weill JS, Lubin S "Modafinil, a double blind multicentric study" Sleep 1994 Dec 17 (8) 5107-112.
9. Bastuji H, Jouvet M "Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil" Prog Neuro Psy Pharm 1988 12 (5) 695-700.
10. Saletu B, Frey R, Krupka M, Anderer P, Grunberger J, Barbanoj MJ "Differential effects of a new central adrenergic agonist- modafinil and d-amphetamine on sleep and early morning behaviour in young healthy volunteers" Int J Clinical Pharm Res 1989 9 (3) 183-185.
11. Lagarde D, Batejat D, Van Beers P, Sarafian D, Pradella S "Interest of modafinil, a new psycostimulant during a sixty hour sleep deprivation experiment" Fund Clin Pharmacol 1995 (9) 3- 271-9.
12. Broughton RJ, Fleming JA, George CF, Hill JD, Kruger MH, Moldofsky H, Montplasir JY, Morehouse RL, Moscovitch A, Murphy WF "Randomised double blind placebo controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy" Neurology 1997 Aug (49) 2 P444-451.
13. Basset A, Chetrit M, Carlander B, Billard M "Use of modafinil in the treatment of narcolepsy, a long term follow up study" Neurophysiol Clin 1996 26 (1) 60-66.
14. Arnuff I, Homeyer P, Garma L, Whitelaw WA, Derenne JP "Modafinil in obstructive sleep apnea hypopnea syndrome, a pilot study in 6 patients" Respiration 1997 64 (2) 159-161.
15. Boivon DB, Montplisir J, Petit D, Lambert C, Labin S "Effects of modafinil on symptomatology of human narcolepsy" Clin Neuropharmacol 1994 Fed 16 (1) 46-53.
16. Lyons TJ, French J "Modafinil the unique properties of a new stimulant" USAF School of Aerospace, Brooks TX (Science News Note 1991, 62 432-5).
17.Laffont F, Cathala HP, Kohler F "Effect of modafinil on narcoleptic and idiopathic hypersomnia" 5th Euro Cong sleep research, Copenhagen 1987 586.
18. Laffont F,Cathala HP, Waisbord P, Kohler F "Effect of modafinil on narcoleptic patients" 9th Euro Cong sleep research, Israel 1988; 26.
19. Bastuli H, Jouvet M "Traitement des hypersomnies per la modafinil" La Press Medicale 1986 15 (28) 1330.
20. Goldenberg F, Weil JS, Van Frenkeel R, "Effects of modafinil on diurnal variation of objective sleepiness in normal subjects" 5th Int Cong Sleep Research 1987 (149).
DISCLAIMER: ALL INFORMATION IS EDUCATIONAL AND PROVIDED UNDER IAS TERMS & CONDITIONS. IT DOES NOT, AND SHOULD NOT, REPLACE THE ADVICE OF YOUR PHYSICIAN.
there's tons of info on it. our own sponser Bodies by Design carries it at a great price.
you can get alot of info at www.antiaging-systems.com (not a plug Mods, but feel free to edit if need be)
Here's an article I pulled:
Modafinil, The Unique Stimulant?
By Robert Mason PhD
Modafinil is an eugeroic drug, (which simply means "good arousal"). This unique class contains only two at present, adrafinil and modafinil, both of which have been developed by Lafon Laboratories of France. Currently, their use and effectiveness is little known outside of Europe.
The basis of their uniqueness lies in their ability to only "stimulate when stimulation is required." As a result the "highs and lows" associated with other stimulants such as amphetamine are absent with eugeroics.
Their initial use often produces comments such as "I can't tell any difference." But it is only several hours later when one realizes that attention and awakeness are the same as earlier, that one is aware of their benefit.
Eugeroics have been designed to treat narcolepsy (sleeping in the day), hypersomnia (excessive sleep) and catoplexy (a condition of sudden muscular weakness or fatigue). Yet eugeroics don't affect normal sleep patterns nor are they addictive and they have far fewer side effects than the current prescribed stimulants.
Modafinil its eugeroic action
One study (5) on rats suggested that one possible vigilance enhancing property of modafinil was its ability to inhibit the release of GABA, through an action on 5HTP serotonin receptors. However, the doses used were far higher than normal therapeutic doses.
Meanwhile, most clinical studies point to modafinil as a unique and highly selective agonist of brain postsynaptic receptor sites called, alpha-1 adrenergic (1,2,7,8,9,10).
These sites are receptive to the neurotransmitter- Norepinephrine (NE). The central function of NE is a fairly recent discovery, it appears to regulate alertness and the waking- sleep cycle and has a role in the maintenance of attention, memory, learning, cerebral plasticity and even has neuro-protection qualities (2).
Central nervous stimulants (CNS) such as amphetamine or pemoline are the most widely used drugs to treat narcolepsy, hypersomnia and catoplexy, but these have a number of well documented problems, such as cardiovascular side effects, interference with sleep, psychiatric disturbances and addition.
Two studies (3,10) directly compared the affects of modafinil and d-amphetamine on sleep. Both double blind controls involved about twelve individuals, one study was undertaken on individuals whose mean age were 68, the other on much younger volunteers.
They utilized 100mg or 200mg of modafinil, or 10mg or 20mg of d-amphetamine or a placebo. All the drugs were administered orally and sleep scales, awakening quality and psychometric tests were completed in the morning.
The outcome of both tests showed that d-amphetamine caused a dose dependant impairment of sleep maintenance, but modafinil did not.
Herein lies the problem for those who have difficulty staying alert and awake during the day. The use of "classic" stimulants such as amphetamines threaten to reduce total sleep time and REM sleep, this will ultimately mean higher and higher doses are required and thus creates a vicious circle.
On the other hand, modafinil has not been shown to interfere with nighttime sleep, thus clearly indicating that the two compounds operate by different methods.
Modafinil its studies and clinical trials
Numerous studies on animals since the mid-1980's have confirmed the ability of modafinil to increase awakeness and alertness without serious side effects, or dependency.
One test on rats (4) produced an interesting result. The researchers discovered that modafinil decreased feeding and reduced body-weight! The amounts of modafinil required were not dose dependent and there was no alteration in the drink- feed ratio. Their conclusion was a reference to the possible mechanisms that underlie the relation between sleep, feeding and metabolism.
Various human trials have concentrated upon modafinil as a therapeutic agent to help maintain alertness and vigilance. A note worthy conclusion of one clinical trial (10) compared modafinil to amphetamine and described amphetamine as "vigilance increasing" but modafinil as "vigilance promoting." This is an interesting comment because as we've seen, modafinil won't prevent a person from sleeping if they want to, but if they wish to remain awake they will do so with a far greater alertness.
This was borne out in one clinical trial (11) where volunteers were subjected to 60 hours of sleep deprivation! During their continued wakefulness, their vigilance was assessed using questionnaires, analogue visual scales and sleep latency tests.
The subjects received either 200mg modafinil or a placebo every 8 hours. The modafinil group sustained a satisfactory level of vigilance with an absence of sleep episodes, unlike the placebo group who gradually declined and slipped into "micro-sleep" episodes, (as one might expect when awake for longer than 24 hours!)
A French study (9) conducted over 3 years, discovered that modafinil reduced drowsiness in 83% of hypersomniac patients and 71% of narcoleptics. Modafinil did not produce peripheric side effects, disturb night sleep and it was never responsible for drug dependence.
Another French study conducted with 149 patients over a period of 2 years (13), was treating patients with narcolepsy-cataplexy at 200mg to 400mg daily. The patients were then asked to score the benefit of modafinil themselves from 0 (no affect) to 3 (excellent affect), 64.1% of the subjects scored it as excellent.
An earlier study (17) with 123 patients, which also included those suffering with hypersomnia, physicians evaluated the patients on a scale of 1 (no affect) to 4 (excellent affect). The results? 17% excellent response, 63% good response, 17% fair and 3% no affect. The incidence of side effects were minimal (14 of the 123 patients had side effects, 11 of whose side effects disappeared when doses were reduced).
These results have been repeated in a number of smaller clinical trials (8, 12, 14, and 15) and confirm modafinil's excellent response to treating individuals suffering with narcolepsy, hypersomnia and catoplexy. Its efficacious use in conjunction with a virtual absence of side effects, non contraindication with normal sleep patterns and lack of drug dependence, certainly indicates that eugeroics are a breed apart from conventional stimulants.
Modafinil the military angle
It is fascinating to see that several countries armed forces have studied (and use!) modafinil for military operations. The use of stimulants to keep troops awake and alert is not a new one. It is known that British troops used them during the Falklands conflict and that USAF aircrews took amphetamines during the Libyan air strikes.
More recently the French government admitted that its crack Corp- the Foreign Legion- used modafinil during covert operations inside Iraq during the Gulf war.
In fact, Professor Michel Jouvet, an authority on sleep, claimed during an international defense meeting in Paris that, "modafinil could keep an army on its feet and fighting for three days and nights with no major side effects."
Not surprisingly then, we have heard that modafinil is in use in some sections of the Belgian, Dutch and US airforces.
Modafinil doses, contraindications and side effects
Side effects in 3 years continuous studies of modafinil have been minimal and usually noted as nothing more than headache or nausea, at therapeutic dosages (17, 18).
In rare cases there has been hyper-salivation (19) and moderate tachycardia (increased pulse rate- 20), this probably accounts for modafinil's instruction sheet, which states that those suffering from a heart condition must consult their physician before use. However, blood and pulse rates usually remain unchanged at normal therapeutic doses.
In fact, a suicidal 21-year-old female who ingested 4500mg demonstrated the relative safety of modafinil. Her side effects were limited to tachycardia, excitation and insomnia (9). As is common with most drugs, modafinil should not be used by those with serious liver disorders, or women who are pregnant or nursing.
The official insert for the modafinil package remains unclear as to the precise drug contraindications, but as it is an alpha-adrenergic agonist, those drugs that represent alpha-adrenergic antagonists should be avoided. These include prazosin, phentolamine or beta-blockers such as propranolol (Inderal).
Furthermore, drugs that enhance norepinephrine activity (such as Yohimbine) should only be used with care, as there may be a synergistic affect.
Adrafinil is noted as contraindicated with epilepsy and has been shown to enhance the potency of anti-epileptic drugs such as phenytoin (Dilantin/ Epanutin). Although this isn't mentioned in any of the modafinil literature we have read, it is best being advised of.
As for dosages, there seems to be little difference in doses and more importance placed upon regular administration (12). Those who simply wish to remain awake and alert will benefit from a single 100mg dose. To remain "on-call" all day, 100mg in the morning and another 100mg in the afternoon is probably all that is required. For those wishing to remain awake during the night, then another 100mg in the late evening (in other words approximately every 8 hours).
Dosages for those suffering from narcolepsy, hypersomnia and catoplexy are 100-200mg morning and afternoon. Some of the doses in trials have been as high as 600mg to 700mg daily (9) although doses over 500mg daily may cause euphoria, slight motor excitation or even insomnia!
Modafinil a comparison with Adrafinil
At first glance there may appear to be little difference between the two. It is true that modafinil is more potent, "average" doses of adrafinil are in the region of 600mg to 1200mg daily, compared to modafinil's 200mg to 400mg daily and this is self evident by the respective tablet sizes.
However, if one were to compare adrafinil and modafinil on price alone then adrafinil would win hands down! So the question must be asked, why did Lafon produce a newer analogue of adrafinil?
The answer probably lies in two parts. Firstly, it is thought that adrafinil may not be such a highly selective alpha-1 adrenergic as originally thought and may also affect other alpha receptors, (albeit in a minute fashion).
Secondly, adrafinil is attributed to some other possible side effects that have not been associated (to date) with modafinil, including, stomach pain, skin irritations, inner tension and in long term use (over 3 months usually), an increase in liver enzyme levels, (which is reversible by reduction or withdrawal).
It is our guess that it is this last potential side effect that lead to the development of modafinil. Clearly adrafinil requires regular blood testing to monitor liver enzyme levels and this may prove inconvenient, to those patients who would need to use eugeroics on a regular basis.
As none of the clinical reports we have read indicate any such problem with modafinil, it would appear that the analogue has achieved its desired aim.
Modafinil the conclusion
We were going to reiterate and condense the above article into a few lines, but the conclusion of the Aerospace Medical Association article (16) on modafinil was so good we will leave the last words to them.
"The development of modafinil brings to light a crucial social question. What would be the impediment for its use, if a compound such as modafinil is more like caffeine than amphetamine in terms of safety, and yet, as effective as the amphetamines?"
Our answer? Only time will tell (although looking around the so-called civilized world and seeing the rapid disappearance of individual rights through centralized bureaucratic control, we wouldn't bet on it! -ed.). These are changing and challenging times indeed.
References
1. Lamberg L "Narcolepsy researchers barking up the right tree" JAMA Sep. 96, 11 276 (10) 765-766.
2. Jouvet M, Albarede JL, Lubin S, Meyrignac C "noradrenaline and cerebral aging" Encephale May 1991 17 (3) 187-195.
3. Saletu B, Frey R, Krupka M, Anderer P, Grunberger J, Barbanoj MJ "Differential effects of a new central adrenergic agonist- modafinil and d-amphetamine on sleep and early morning behaviour in elderly" Arzneimittelforschung Oct 1989 39 (10) 1268-73.
4. Nicoladis S, DeSaint, Hilarre Z "Nonamphetamine awakening agent modafinil induces feeding changes in the rat" Brain Res Bull 1993 (32) 2 87-90.
5. Ferraro L, Tanganelli S, O'Connor WT, Antonelli T, Rambert F, Fuxe K "The vigilance promoting drug modafinil decreases GABA release in the medial preoptic area and in the posterior hypothalamus of the awake rate; possible involvement of the serotonergic 5-HT3 receptor" Neuro Sci Lett 1996 Dec 6 220 (1)
6. Gold LH, Balster RL, "Evaluation of the cocaine like discriminative stimulus effects and reinforcing effects of modafinil" Dept of Phar & Tox, Med Coll VA, USA.
7. Maffont F, Mayer G, Minz M, "Modafinil in diurnal sleepiness, a study of 123 patients" Expl Fonct Neuro CHU Parid France. Sleep 1994 Dec 17 (8) 5113-115.
8. Billiard M, Besset A, Montplasir J, Laffont F, Goldenberg F, Weill JS, Lubin S "Modafinil, a double blind multicentric study" Sleep 1994 Dec 17 (8) 5107-112.
9. Bastuji H, Jouvet M "Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil" Prog Neuro Psy Pharm 1988 12 (5) 695-700.
10. Saletu B, Frey R, Krupka M, Anderer P, Grunberger J, Barbanoj MJ "Differential effects of a new central adrenergic agonist- modafinil and d-amphetamine on sleep and early morning behaviour in young healthy volunteers" Int J Clinical Pharm Res 1989 9 (3) 183-185.
11. Lagarde D, Batejat D, Van Beers P, Sarafian D, Pradella S "Interest of modafinil, a new psycostimulant during a sixty hour sleep deprivation experiment" Fund Clin Pharmacol 1995 (9) 3- 271-9.
12. Broughton RJ, Fleming JA, George CF, Hill JD, Kruger MH, Moldofsky H, Montplasir JY, Morehouse RL, Moscovitch A, Murphy WF "Randomised double blind placebo controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy" Neurology 1997 Aug (49) 2 P444-451.
13. Basset A, Chetrit M, Carlander B, Billard M "Use of modafinil in the treatment of narcolepsy, a long term follow up study" Neurophysiol Clin 1996 26 (1) 60-66.
14. Arnuff I, Homeyer P, Garma L, Whitelaw WA, Derenne JP "Modafinil in obstructive sleep apnea hypopnea syndrome, a pilot study in 6 patients" Respiration 1997 64 (2) 159-161.
15. Boivon DB, Montplisir J, Petit D, Lambert C, Labin S "Effects of modafinil on symptomatology of human narcolepsy" Clin Neuropharmacol 1994 Fed 16 (1) 46-53.
16. Lyons TJ, French J "Modafinil the unique properties of a new stimulant" USAF School of Aerospace, Brooks TX (Science News Note 1991, 62 432-5).
17.Laffont F, Cathala HP, Kohler F "Effect of modafinil on narcoleptic and idiopathic hypersomnia" 5th Euro Cong sleep research, Copenhagen 1987 586.
18. Laffont F,Cathala HP, Waisbord P, Kohler F "Effect of modafinil on narcoleptic patients" 9th Euro Cong sleep research, Israel 1988; 26.
19. Bastuli H, Jouvet M "Traitement des hypersomnies per la modafinil" La Press Medicale 1986 15 (28) 1330.
20. Goldenberg F, Weil JS, Van Frenkeel R, "Effects of modafinil on diurnal variation of objective sleepiness in normal subjects" 5th Int Cong Sleep Research 1987 (149).
DISCLAIMER: ALL INFORMATION IS EDUCATIONAL AND PROVIDED UNDER IAS TERMS & CONDITIONS. IT DOES NOT, AND SHOULD NOT, REPLACE THE ADVICE OF YOUR PHYSICIAN.
- Joined
- Jul 21, 2002
- Messages
- 11,597
leapfrog said:personally i like my adderral script,helps me focus,lean up,&control my add
leap
ps.my friend told me provigil 200mg works great but gave him & his girl brutal headaches.i still want to try it and see how it works.
leap
The headache side concerns me,,,looking for more mental, physical energy with less side than ECA, Clen or stimulants. I may try 100mg per day to start.
- Joined
- Dec 8, 2004
- Messages
- 992
Alin said:
I did 200mgs this AM, and was set for the day.
theres no buzz, its not like you feel it. You just don't feel sluggish or tired.. If you don't feel sluggish or tired, I dont know what it would feel like at 100mgs, probly nuthin
OuchThatHurts
Moderator / Psy, Ret.
Staff member
Moderator
Kilo Klub Member
Registered
Verified Customer
- Joined
- Nov 6, 2005
- Messages
- 10,566
I do not prescribe it. Many sleep centers use it to combat the daytime effects of sleep apnea all the way to narcolepsy. This is why it was prescribed in your case and the 10-12 hours makes sense because that's it's active life. I can check out the PDR and get more info on it because it's just not within the range of meds I need to employ. I'm usually trying to put people out not wake them up! Little humor there...edge250 said:
Alin, if you can get it (which I know for a fact that you can), I'd suggest starting out at a low dosage since I believe you're not suffering from sleepiness but just want a mild boost right? It comes in 100 and 200mg tabs and I suggest breaking a single 100mg tab and taking it on an empty stomach (i.e. not with food). For you, you can do wholesale which will be a lot cheaper than retail. I assume your pockets are deep enough though either way... Can you let me know how you react by PM or on here? I can't take clen or any beta-agonists for that matter - my body flips out.
Alin, that reminds me, I need to talk to you.
OTH
- Joined
- Sep 13, 2005
- Messages
- 3,540
edge250 said:
Intresting I am just about to got to bed to use a pluse oximeter I got from my hospitial to see if I have sleep apnea. This drug sounds very promsing as I sometimes have to use ephedrine to get me trough the day.
- Joined
- Jun 4, 2002
- Messages
- 14,362
I like it. Two nights ago I was hauling my ass in the lambo until 4am and then I had to get up at 7am, so only 3 hours sleep. The modavigil (provigil) saved my day.
I use it when I lack sleep.
You'll like it.
I use it when I lack sleep.
You'll like it.
Similar threads
Members online
- Standfast
- Doitagain
- megroo
- buffone77
- demon
- steve0691
- kadafi2
- ChefTren
- KrAven
- dxteran
- Nate Dawg
- Durro
- Growthfreak
- Alzadosghost
- Cdubw44
- Pheedno
- sciroxx-lab
- TheOtherOne55
- musclefreak47
- soonerfanatic
- Simak
- Goodfella1988
- slesh
- Big Vin
- iron lifter
- Palifter
- Fa Seeshus
- IceCream
- mikelew
- WskyCowboy
- Duke309
- mimo
- grammo13
- rifleman
- 302
- 360
- hassan
- td
- Quadlife
- Bataille
- Hulk8tiny
- tbda
- EspenMuskelbunt1
- Trenloverboy
- LordBrolly
- Meyerr13
- strummer
- traininsane11
- mansir
- Flocci
Forum statistics
