Question about enlarged prostate

[SouthernMuscle]

Hope you don’t mind i quoted you here, seemed the appropriate thread, and didn't want to derail the other

I want to stay on topic but do want to answer your question.

Essentially prostate cancer cells need male sex hormones, like testosterone, to keep growing.

My dads was stage 5, metastasized to his bones and other parts of his body. He did not live long at this stage as it was not curable. His PSA was 999.

All they could do was slow the growth which was done though chemical castration him so his body did not produce any testosterone.

Now back to the original topic.

They’re now learning more and more that estrogen and estrogen receptors play a large role in prostate cancer, still not fully elucidated. Very interesting

Estrogen Receptors Promote Migration, Invasion and Colony Formation of the Androgen-Independent Prostate Cancer Cells PC-3 Through β-Catenin Pathway - PubMed

Prostate cancer is initially dependent on the androgen, gradually evolves into an androgen-independent form of the disease, also known as castration-resistant prostate cancer (CRPC). At this stage, current therapies scantily improve survival of the patient. Androgens and estrogens are involved...

pubmed.ncbi.nlm.nih.gov

 

[alfresco]

Hope you don’t mind i quoted you here, seemed the appropriate thread, and didn't want to derail the other



They’re now learning more and more that estrogen and estrogen receptors play a large role in prostate cancer, still not fully elucidated. Very interesting

Estrogen Receptors Promote Migration, Invasion and Colony Formation of the Androgen-Independent Prostate Cancer Cells PC-3 Through β-Catenin Pathway - PubMed

Prostate cancer is initially dependent on the androgen, gradually evolves into an androgen-independent form of the disease, also known as castration-resistant prostate cancer (CRPC). At this stage, current therapies scantily improve survival of the patient. Androgens and estrogens are involved...

pubmed.ncbi.nlm.nih.gov

No worries man.

Very interesting. Thank you for that. News to me as is adding in testosterone therapy Who knew. Kinda counterintuitive wouldn’t you think?

And you know what, I always suspected, did not know, that estrogen might have played a role. True story.

 

[SouthernMuscle]

No worries man.

Very interesting. Thank you for that. News to me as is adding in testosterone therapy Who knew. Kinda counterintuitive wouldn’t you think?

And you know what, I always suspected, did not know, that estrogen might have played a role. True story.

I haven’t even scratched the surface of the data. In pubmed for the terms “prostate cancer estrogen” theres over 400 results just from 2020-2023. Obviously some of those won’t be applicable but still.