Media Grade: This is the more usual grade of Long R3 IGF-1 that you see on the market. It is about 95% pure IGF-1 with some other incomplete peptides in it. And since the dose of IGF-1 is so small, the maximum 5% impurities of media grade represent a truly tiny amount. And the meaning of impurities in this context is simply some amino acids, either loose or in peptide form. In all likelihood that 5% of non-IGF-1 peptides is truly harmless.
Receptor Grade: Receptor-grade IGF-1 is guaranteed to be at least 99% pure Long R3 IGF-1 peptide. This grade is only used in advanced human trials in very specific spots on the planet. It is a truly rare thing and does not offer the bodybuilder any real-life advantage over media grade. It is also unavailable. There has been batches of some substance sold as "Receptor grade IGF-1" over the last year or so and here a very serious warning must be given. There is a peptide which is only the receptor binding portion of the IGF-1 molecule, which is a cellular lab product which contains bovine peptides and prions. This stuff has no other function than to bind to the IGF-1 receptor. It has no beneficial properties but blocks the receptor from being used by actual IGF-1. Some very bad or misinformed people have been selling this to bodybuilders as receptor grade IGF-1. This stuff can be very toxic. Prions cause CNS trouble of which mad cow disease is an example.