- Joined
- Jul 28, 2009
- Messages
- 6,319
Anyone taking hCG should definitely add NAC to their program to prevent Leydig desensitization (always a problem when using HCG).
Differential modulation of apoptotic gene expression by N-acetyl-l-cysteine in Leydig cells stimulated persistently with hCG in vivo
I edited out the dosage amounts because they do not apply to humans, you can see them in the original study, I wouldn't use this study as a dosing guide...
Differential modulation of apoptotic gene expression by N-acetyl-l-cysteine in Leydig cells stimulated persistently with hCG in vivo
The present study was designed to investigate the molecular mechanisms of NAC action in vivo under repeated hCG stimulation to adult rats. Leydig cell refractoriness led to a significant decline in serum testosterone and intracellular cAMP by day 30 of chronic hCG intervention which improved significantly following NAC co-administration. It inhibited the rise in lipid peroxidation, improved the activity of antioxidant enzymes along with intracellular glutathione and total antioxidant capacity in the target cells.
I edited out the dosage amounts because they do not apply to humans, you can see them in the original study, I wouldn't use this study as a dosing guide...
Last edited: