Many HRT clinics here in South Florida are not RXing HCG any more. Something about laws and difficulty getting it. In March of 2020, the FDA reclassified HCG as a biologic. This change in classification means that compounding pharmacies, where all weight loss clinics order their HCG, would no longer be able to produce HCG because it requires the pharmacy to gain different licensure granted by the FDA.
They have started RXing the med Gonadorelin now. It arrives already constituted and you don't have to keep it in the fridge. Sometimes they even send tabs - which I think are completely useless.
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Gonadorelin is a synthetic gonadotropin releasing hormone that, like HCG, increases luteinizing hormone (LH), but also activates follicle stimulating hormone (FSH) which is something HCG does not do. Gonadorelin does so by stimulating the pituitary gland which is vital in the manufacturing of testosterone in the testicles. That stimulation provides a “double kick” in regard to potential testosterone production which replicates what occurs during puberty when the body is at its height in regard to secretion of hormones for growth and sexual development. In doing so, Gonadorelin can reverse testicular atrophy and even increase seminal volume – which would be considered a huge advantage to a lot of men.
The reason Gonadotropin is less known is that it has been used mostly to “test” how well the pituitary and hypothalamus are working in cases where women are experiencing abnormal menstrual cycles. Yet, the fact that it also works like HCG to increase androgen production is becoming something that is of considerable interest in the field of male HRT and life extension. The one area where HCG has a slight advantage is that it has the odd side effect of spurring weight loss; whereas, Gonadorelin doesn’t seem to share that component.