I just watched and he is referring to some study that he saw. He said that the g.h. decreases(in a week or less) , but it already sent the igf-1 through the roof, which will be maintained longerm because 1gf-1 stays elevated for awhile. Now the study I posted shows that it takes a full month for igf-1 to peak. Wish he would come on here and clarify but he does state all the "unanswered" questions so I think he is confused as well.
Actually, studies show that IGF-1 levels continued to RISE for an entire year. Now, they were about 80% of the way they after 1 month, but they did go up another 15-20% over the following 11 months.
I know many people who have used it for a year or longer and still love it, which isn't surprising because IGF-1 levels are as high as ever at that point. I've been on about 1.5 years (aside from taking off a few weeks) and I have no plans of discontinuing.
This subject requires more research, as MK's effects on GH and IGF-1 levels are two different things. Since IGF-1 and GH are substantially different hormones with different effects in the body, understanding how the compound works on these hormones over the short and long-term would help us better understand how to implement it for the achievement of various goals.
The pharmacokinetic and pharmacodynamic discrepancy between exo. GH and MK-677 is likely why users have noticed that MK and GH do not provide identical cosmetic effects (particularly when it comes to fat loss), despite both compounds working primarily through the same two hormones (GH and IGF-1).
I've always believed that a comparable dose of exo. GH is superior for fat loss, but I've also found that 25 mg of MK-677 (used daily) is significantly more effective (in my experience and those of many others I know, some of whom are posting in this thread) for adding size and enhancing growth than low-moderate doses of exo. GH (2-4 iu/day).
I grow very little, if at all, from 3.3 iu of GH/day. On the other hand, 25 mg of MK produces near immediate and profound gains in bodyweight, muscle fullness, and strength, while also indirectly enhancing growth through increased appetite and improved sleep quality.
Of course, high dose GH use still reigns supreme from a growth standpoint, but for many there is not a single other non-steroidal drug that is as cost-effective as MK-677, from a growth and recovery standpoint. For very little money someone can purchase a 30-60 day cycle of MK-677 and experience very noticeable changes in their physique within a short period of time.
In my opinion, MK is a near perfect, low-cost compliment to a growth cycle, particularly for those individuals who struggle to eat all the clean food they need to make maximum muscle gains while minimizing bodyfat build-up. It just makes it so much easier to do one's job at the dinner table, day in and day out.
In fact, I have often stated that I believe ghrelin mimetics (in general) to be one of the most valuable recent additions to the PED marketplace, as no other class of compound is capable of stimulating the appetite as profoundly as the ghrelin mimetics without causing any serious side effects (even when used chronically over an extended period of time). In addition to appetite stimulation, ghrelin mimetics also contribute to a bodybuilder's primary goals by providing direct growth benefits (IGF-1 elevation, etc).
Remember when bodybuilders used to use insulin with every meal just so they could eat more food (some still do)? Well, that approach leads to all sorts of potential health problems...and ultimately leads to the deterioration of one's physique. This deterioration first begins with one's appearance (the bodybuilder's overall shape, lines, muscular detail begins to take a turn for the worse), followed by a gradual loss of muscle mass. This is caused by several factors, the most damaging of which is severe insulin resistance. When severe insulin resistance is allowed to persist over the long-term it prevents nutrients from entering muscle cells via Glut-4 down-regulation. This muscle loss initially starts in the limbs (as it typical of diabetics) and gradually extends inward, affecting the muscles of the torso.
Other factors, such as systemic inflammation (which is also caused by chronically elevated BG and insulin levels; a hallmark of insulin resistance), promotes promotes muscle atrophy via decreased muscle protein synthesis and increased ubiquitin-proteasome, lysosomal-proteasome and caspase 3-mediated protein degradation. The evidence also suggests that the inflammation-sensitive Nuclear Factor KB and Signal Transducer and Activator of Transcription 3 pathways may play a role in muscle atrophy in those afflicted with insulin resistance.
It has always been my contention that ghrelin mimetics (such as MK-677) are equally effective in stimulating the appetite, but without causing any of the negative effects typically associated with insulin abuse. For many, it has become a staple in their program and will continue to be for as long as it remains available.