Key Points:
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189634/
- TREN induced a greater magnitude of Fat loss than Testosterone.
- TREN binds to ARs with approximately 3x the affinity of Testosterone and an affinity roughly equal to that of DHT, the most potent endogenous androgen
- Even Low dosage TREN is more Anabolic than Supraphysiological Testosterone dosages
- TREN increases responsiveness of skeletal muscle to IGF1
- The aromatization of Testosterone appears to be essential for bone development in men, as demonstrated by the identification of several men who suffer from aromatase deficiency resulting in the Osteopenia, which is treatable with Estradiol but not Testosterone
- TREN and its primary metabolites are non-estrogenic, and in vivo evidence demonstrates that TREN induces Anti-estrogenic effects in oviparous species
- the anti-estrogenic effects and apparently nonaromatizable aspects of TREN partially underlie the slightly diminished bone-protective effects and the apparent adynamic bone state (i.e., reduced markers of bone resorption and bone formation) that we observed following TREN treatment of ORX animals.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189634/