It happens so often though LOL. But it says something is happening at the testicle level right? Palumbo has that pet theory that at very high doses testosterone builds up in the testicles and can stimulate spermatogenesis among other thing. But one thing is true, the testes change in size quickly even at very high dosages, but Trest is extra suppressive judging by testicle size. Like castrated in a way though you feel the androgen effects anyway. The testes are mostly their biggest in the morning after a good nights sleep, there is some type of activity going on despite supposedly being "fully shut down." Testicle size does signify something.