17aa orals best absorbed on an empty stomach?

ironone1 · May 25, 2009

I've heard different opinions of some saying to take orals with meals and others say that 17aa orals are best absorbed on an empty stomach. What is the best way to take them for the most absorbtion?

doug1 · May 26, 2009

i don't think there is a problem with absorbtion. why do you think there is a problem?

ironone1 · May 26, 2009

doug1 said:
i don't think there is a problem with absorbtion. why do you think there is a problem?

Well, like amino acids, it's recommended that you take them on an empty stomach for best absorbtion. It must make a difference if they tell you to take them a certain way, right? Orals you piss some of it out, injections its better absorbed, right? Do you think you absorb everything 100% when you take it orally? Comprendo, capice?

doug1 · May 26, 2009

if there is a study showing one method(empty stomach vs. with food) better than the other i'm not familiar with it, i really don't think it matters. i think the absorbtion is excellent either way with the 17a oral steroids. i personally if i have the time like to try and get it sublingually as to avoid the liver processing. i'm not sure why you say that orals some get pissed out, i haven't heard that. truth is, the orals are some of the most potent steroids for strength and size your body will ever know.

ironone1 · May 26, 2009

doug1 said:
if there is a study showing one method(empty stomach vs. with food) better than the other i'm not familiar with it, i really don't think it matters. i think the absorbtion is excellent either way with the 17a oral steroids. i personally if i have the time like to try and get it sublingually as to avoid the liver processing. i'm not sure why you say that orals some get pissed out, i haven't heard that. truth is, the orals are some of the most potent steroids for strength and size your body will ever know.

Yeah but they aren't absorbed as much as an IM injection going through the liver. Empty stomach with grapefruit juice is supposed to be the best. I know orals are strong.

Flexican · May 26, 2009

i did read a study once about dianabol being reccomended that it be taken throughout the day as traces were found not metabolized in urine of those who took one big dose as opposed to spread out.

Newman · May 26, 2009

ironone1 said:
Yeah but they aren't absorbed as much as an IM injection going through the liver. Empty stomach with grapefruit juice is supposed to be the best. I know orals are strong.

You're probably right on the 17aa & grapefruit juice thing, but I tried that with some UG Viagra & got a splitting headache that lasted 3 days, so DON'T do that with Viagra unless you really like pain...

ironone1 · May 27, 2009

Newman said:
You're probably right on the 17aa & grapefruit juice thing, but I tried that with some UG Viagra & got a splitting headache that lasted 3 days, so DON'T do that with Viagra unless you really like pain...

Viagra gave me headaches. I think because it raises your blood pressure. I don't know if it was due to the grapefruit juice, it might have been.

boattail · May 27, 2009

i've tried it both ways and haven't noticed a difference in results

beeman · May 27, 2009

Viagra will cause vasodialation and will lower blood pressure, that is why you have to watch the pde5 inhibitors with nitrates.

They recommend bcaa's on an empty stomach because if taken with food, there is competition in the stomach and you wont get the full effect. It would just be as if you ate more protein, but a very expensive protein.

Very few drugs are absorbed better on an empty stomach, a few are syntroid (t4) and capoten (captopril), but honestly if you dont have any stomach issues, we are talking an extra few percent and it really isnt going to matter.

KillerStack · May 27, 2009

ironone1 said:
I've heard different opinions of some saying to take orals with meals and others say that 17aa orals are best absorbed on an empty stomach. What is the best way to take them for the most absorbtion?

With food that contains some fat. Steroids are lipophilic and fats should enhance uptake I believe.

EasyEJL · May 28, 2009

the whole point of the methylation is to make them more absorbable, which is why the handful of non-17aa orals (like some of the prohormones) are supposed to be taken with fats to aid their absorption

ironone1 · May 28, 2009

EasyEJL said:
the whole point of the methylation is to make them more absorbable, which is why the handful of non-17aa orals (like some of the prohormones) are supposed to be taken with fats to aid their absorption

Yeah I remember seeing it posted to take ph's with a fatty meal and 17aa tabs on an empty stomach, so I was a little confused as to what the best way may be with my winstrol tabs. So you guys think with a fatty meal is the best way to go? Maybe a peaunut butter sandwich for breakfast first thing in the morning? So grapefruit juice doesn't matter then? Sorry, I'm a little confused with so many different viewpoints.

EasyEJL · May 28, 2009

you are just overcomplicating things. the difference overall is minor, and you are probably loosing the value of it by driving your cortisol up by being concerned

in my opinion, neither fatty meal or grapefruit juice would have all that much effect on absorption or halflife of winny. white grapefruit juice from duncan grapefruits has naringin, which helps with certain things

Flavonoids from grapefruit juice have been reported to affect hepatic metabolism by influencing Cytochrome P450 enzyme system, or CYP3A4. Many medications are metabolized in the liver by the cytochrome P450 enzyme complex or CYP3A4, including calcium channel blockers, HMG-CoA reductase inhibitors, anxiolytics, and some neuropsychiatrics. Adverse reactions have been reported by this drug-food interaction.

but IIRC doesn't affect winny

EDED · May 28, 2009

anything that blocks your liver doing its job to survive is highly highly DUMB

dont do it, just take your stuff and be happy, 17aa means alot, it means everything it means it will get untouched and hang around all over you then get pissed out, so what, im sure big pharma spent millions on research they probably covered that area, it passed so it must be okay,,,, some gear 17aa or not gets pissed out without being metabolized, no biggie. dose it according to your gains or sides, be nice to your liver.

another thing to think about,,,some AAS metabolites are actually involved in 'gains' taht we talk about, so aromatase or 5ar inhibitors or cytochrom blockers will change things.