This is how I look at it based on mostly my experiences with talking with vets and not actually my own experience.
First off, my personal experience reallly has shown me my body doesnt react a whole lot different to the two methods of building muscle. My body responds more to the rest and food aspects. I also save myself from injuries with lighter, and when I say light I mean light enough to fail at 12-20 reps giving it everything you have to give and more.
The biggest guys I've talked to have lifted MASSIVE weight in their lifetime at some point and for a decent amount of time. Typically in their younger years (20's or so) and then have switched over to higher rep work yet still maintaining some impressive numbers. This has been the circumstances over and over again from guys I talk to.
So basically you build up the muscle fastest while young and can handle those big boys numbers yet also be able to take nice punishment to your body without any massive injuries to put you out completely. But this period of time (if you want to stay healthy and functional later in life and not a Oxy dependent drug addict due to being in massive pain all the time with blown joints, bulging disks in your back and whatever else) isnt the main focus for too long with the intelligent and sucessful vets I've talked to. After lifting so heavy for say 10 years you're going to be a monster, so even at higher rep sets these guys are still pushing some seriously impressive weight by this point after their young invincible days. And as you get older your reps get higher to save your joints.
FOr example, look at Ronnie Coleman. Dude is a fucking MESS. I cant imagine how much pain he is in taking a 10 minute walk in the morning. His body looks pretty damn horrendous to be fair here considering he was the King of bodybuilding for all those years.
Then take a look at Dexter Jackson. Just as old yet still placing top 5 or 6 at the olympia for all these years and looks absolutely in picture perfect health. Immaculate physique and injury free. Bet the dude could run a damn 10k if he wanted with just a minimal amount of preparation.
On the other hand Ronnie has a torn lat that looks pretty damn bad, his body has been torn and ripped apart from head to toe from heavy weight lifting until his ending days and it sure shows now.
Genetically, both are in the top .5%. They just took completely different routes. Guess it depends what is more important to you? Being King Kong for your lifting years and later on a half disabled mess with constant pain and an incredibly beat up and almost shocking physique or be like Dexter and maybe be in the shadows yet maintain health, injury free all while maintaining your incredible physique that you spent your life creating.
I'll pick Dexter anyday. If it was up to me I'd gladly hand over the Crown whoever wanted it when comparing those two. Ronnie was the biggest baddest dude in the world for nearly a decade, but what is he now? Still impressively huge sure, but take that shirt off and pants off and he might still hear gasps but they arent the kind of gasps that you can be proud about. And to be fair, sure - Dexter still loaded up on gear, Ronnie isnt - but even if he was, his physique is too far gone to even come close to the aesthetics and just overall perfection of Jackson.
Fuck bodybuilding, do it for a hobby, not a obssessive out of control lifestyle due to personal insecurity issues all for NOTHING in the end. People forget quick. Alpha's come and go but they're forgotten as fast as they come up. Be intelligent, above all else maintain balance, keep your AAS use under control, enough to keep you growing and not hitting walls and if you get far enough to be taking multiple grams of stuff to maintain competitive be damn sure to get bloodwork very often and take the correct AIs, liver support, supps, give blood and whatever else I'm leaving out to make god damn sure you can be around to see your kids grow up and make families of their own and function able enough to keep up with the grandkids and be the grandpa all kids want.
Sorry, I got off track big time here. I just look around in amazement at the unpredictable, irresponsible, straight up fucking retarded actions that the majority of the bodybuilding community choose to do on a daily basis.
Back on track - as heavy as you can handle without hurting yourself. Or save yourself a ton of time and risk of injury and just hire John Meadows - he has the most creative and intelligent exercises to ensure optimal growth while saving your body. Not only will feel better but you may just be able to actually do what we're here for - living our lives with people, family, and lifting up others and making a positive difference in the world, no matter how slow or small that may be.
Again, I'm all over here, but my point to be clear is just do whatever ensures growth at a level that you're content and happy with in the most efficient and intelligent way to avoid injury at all costs like the damn plague. One mistep with 5 or more plates on your back and lights out. I have back issues at 27 years old due to my ignorance and ego in the gym. I tore my patella tendon in my knee with just 450 on the third set of 5. Plus, whats more impressive? 405 for 30 reps or 600 for 5? I'd put my money on Mr. 405 every damn time. High reps are tough, it takes some serious mind power to push through and give everything you got as your body is failing on your but yet you still push through and get it done. It recruits more muscle fibres, it takes extreme determination, healthy cardio levels, all while saving your joints and risk of muscle strains and tears.
But like I said, just hire JM and take the thinking out of it completely and just DO.
SOrry for my blabbering, hopefully it makes sense lol - been gone for almost 2 weeks, stilll dealing with jet lag and just a little out of it.