My man... There's multiply studies on ARBs showing the rate of adverse events is the same as in the placebo group or even lower. Yet you act like ARBs and ACEIs are the devil. There's even a study for Telmisartan showing exactly that with double the dose (160mg) than what is generally prescribed (80mg).
It is general consense that this drug Class (ARBs and ACEIs) are known for showing the least side effects of all ever invented bp meds.
"My man" I do not think these drugs are "the deeeeeeevillllll" at all. I think it's bad to promote them for healthy men as a prophylactic because there are risks that also should be considered:
Please refer to:
American Society of Health-System Pharmacists 2014; Drug Information 2014. Bethesda, MD. 2014, p. 2073:
"Symptomatic hypotension may occur in patients with an activated renin-angiotensin system (e.g., patients with volume or salt depletion secondary to salt restriction or prolonged diuretic therapy)...
"Because the RAAS appears to contribute substantially to maintenance of glomerular filtration in patients with congestive heart failure in whom renal perfusion is severely compromised, renal function may deteriorate markedly (e.g., renal failure) in these patients during therapy with an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor antagonist (e.g., telmisartan)...
"Renal artery stenosis also is a risk factor for renal impairment during therapy with drugs that inhibit the RAA system. Although reports received to date have involved patients treated with ACE inhibitors, this adverse effect also would be expected to occur when drugs with similar pharmacologic activity (e.g., angiotensin II receptor antagonists) are used in a similar manner."
LiverTox (NIH):
Telmisartan has been associated with a low rate of serum aminotransferase elevations (Likelihood score: E* (Unproved but suspected rare cause of clinically apparent liver injury).
https://www.ncbi.nlm.nih.gov/books/n/livertox/Telmisartan/
NIH; DailyMed. Current Medication Information for MIicardis (Telmisartan) Tablet (Revised: October 2012). Available from, as of October 9, 2014:
https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=cfb9309f-e0df-4a55-9542-0e869fce05fb
"Hyperkalemia may occur in patients on
angiotensin II receptor blockers (ARBs), particularly in patients with advanced renal impairment, heart failure, on renal replacement therapy, or on potassium-containing supplements, diuretics, salt substitutes or other drugs that increase potassium levels. Consider periodic determinations of serum electrolytes to detect possible electrolyte imbalances..."
Anyone presenting these drugs as risk-free PPARgamma (lulz) modulators and great for fluid retention (oh btw they're blood pressure and diabetic nephropathy meds) is, frankly, dangerous.
.gif "IP Gear")
