Slow build up when increasing vascularity. Think Eq in terms of kicking in as an anabolic. This take time to kick in for most as a vasodialtor. One of the major benefits to this supplement is that it increases the ability to perform cardio with less effort once it does kick in. Great supplement for those wanted to get or stay in athletic shape, (conditioning). To be most effective it must b taken throughout the day. It is also in the Bcaa product extend. i usually by ingredients in bulk and make my own.