QUOTE=DatBtrue;500801
Dosing
...my quick run through the material indicates that there is not much information on dosing. First it is not possible to extrapolate doses used on lab animals to humans so those studies are of limited value. Second the drug company trials which tested for safety used high doses (25mcg/kg to 100mcg/kg). Third the drug company does not care about subcutaneous administration, they want an oral drug so subsequent studies use the oral delivery system where gram level dosing is used.
But from the oral dosing clinical trial one interesting thing emerged... that is that they found 10grams to be equally effective to 20grams and furthermore they found 60grams to have ZERO effect.
That means that there is an upper limit to dosing at which point you not only will get no further benefit BUT ALL benefit is lost and it is as if you took nothing.
The clinical trials though show measurable weekly fatloss. In some cases 1kg per week. This compound is particularly effective in older people...much more than in younger 20-somethings.
I suspect you don't need to take as high a dose as the studies might indicate. I'm not sure even the patent holders yet know the optimal subcutaneous dose. From their patent filing:
"The peptide which is the active ingredient of the pharmaceutical composition of this aspect of the invention exhibits advantageous therapeutic activity in the treatment of obesity in an animal when administered in an amount appropriate to the particular case. For example, from about 0.5 μg to about 20 mg per kilogram of body weight per day may be administered. Dosage regimens may be adjusted to provide the optimum prophylactic or therapeutic response. For example, one or more divided doses may be administered daily, weekly, monthly or in other suitable time intervals or the dose may be proportionally reduced as indicated by the exigencies of the clinical situation."
0.5 μg/kg is .5mcg/kg which is just 50mcg for a 100kg man.
Is such a low dose optimal? Probably not...but you'd probably get a very minimal positive effect from it.
If you combine the fragment Tyr176-hGH(176-191) with CJC-1295/GHRP-6 you will almost undoubtedly increase the fatloss.
Anyway I'm very interested in this compound. If I were in fatloss mode I'd probably add the Tyr176-hGH(176-191) at 100mcg dosed 3 times a day to CJC-1295 (dosed once at night at 100mcg)/ GHRP-6 (dosed three times a day at 100mcg).
The reason to keep the GHRP-6 dosing frequent is that fatty-acids blunt but do not eliminate the GH releasing effect of GHRP-6 as they do with GHRH (of which CJC-1295 is a long-lasting analogue).
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