Fibroblast growth factor 21

[Vespa103]

Ok for those watching this stuff is supposed to put your body into ketosis even if you are eating everything. It also supposedly lowers blood pressure, cholesteral, and glucose levels in blood while increasing sensitivity to insulin without causing hypo. So you eat everything and actually get leaner and healthier to good to be true or start planning dosage chart for a cycle? And yes youcan get it if you look hard enough. I attached one study of diabetic primates but found a lot of em earlier on other computer dealing with ketosis in mice.

http://endo.endojournals.org/cgi/content/abstract/148/2/774

 

[dragonfire101]

Nice post. I'm going to have to do some research on this.

 

[speedbacker]

Will definitely read more about this.

 

[lookingforanedge]

Sounds veryinteresting....keep us posted if you get and try this stuff.

 

[dragonfire101]

http://diabetes.diabetesjournals.org/cgi/content/full/55/9/2470


Going to have to wait there is not alot of research yet.

Pubmed articles

Items 1 - 15 of 15 One page.


1:
Lundasen T, Hunt MC, Nilsson LM, Sanyal S, Angelin B, Alexson SE, Rudling M.
Related Articles, Links
PPARalpha is a key regulator of hepatic FGF21.
Biochem Biophys Res Commun. 2007 Aug 24;360(2):437-40. Epub 2007 Jun 21.
PMID: 17601491 [PubMed - in process]
2:
Moore DD.
Related Articles, Links
Physiology. Sister act.
Science. 2007 Jun 8;316(5830):1436-8. No abstract available.
PMID: 17556573 [PubMed - indexed for MEDLINE]
3:
Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E.
Related Articles, Links
Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARalpha and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States.
Cell Metab. 2007 Jun 6;5(6):426-437.
PMID: 17550778 [PubMed - as supplied by publisher]
4:
Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA.
Related Articles, Links
Endocrine Regulation of the Fasting Response by PPARalpha-Mediated Induction of Fibroblast Growth Factor 21.
Cell Metab. 2007 Jun;5(6):415-25.
PMID: 17550777 [PubMed - in process]
5:
Ogawa Y, Kurosu H, Yamamoto M, Nandi A, Rosenblatt KP, Goetz R, Eliseenkova AV, Mohammadi M, Kuro-o M.
Related Articles, Links
BetaKlotho is required for metabolic activity of fibroblast growth factor 21.
Proc Natl Acad Sci U S A. 2007 May 1;104(18):7432-7. Epub 2007 Apr 23.
PMID: 17452648 [PubMed - indexed for MEDLINE]
6:
Kharitonenkov A, Wroblewski VJ, Koester A, Chen YF, Clutinger CK, Tigno XT, Hansen BC, Shanafelt AB, Etgen GJ.
Related Articles, Links
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.
Endocrinology. 2007 Feb;148(2):774-81. Epub 2006 Oct 26.
PMID: 17068132 [PubMed - indexed for MEDLINE]
7:
Moyers JS, Shiyanova TL, Mehrbod F, Dunbar JD, Noblitt TW, Otto KA, Reifel-Miller A, Kharitonenkov A.
Related Articles, Links
Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling.
J Cell Physiol. 2007 Jan;210(1):1-6.
PMID: 17063460 [PubMed - indexed for MEDLINE]
8:
Wente W, Efanov AM, Brenner M, Kharitonenkov A, Koster A, Sandusky GE, Sewing S, Treinies I, Zitzer H, Gromada J.
Related Articles, Links
Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.
Diabetes. 2006 Sep;55(9):2470-8.
PMID: 16936195 [PubMed - indexed for MEDLINE]
9:
Huang X, Yu C, Jin C, Yang C, Xie R, Cao D, Wang F, McKeehan WL.
Related Articles, Links
Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis.
Mol Carcinog. 2006 Dec;45(12):934-42.
PMID: 16929488 [PubMed - indexed for MEDLINE]
10:
Yamauchi H, Hotta Y, Konishi M, Miyake A, Kawahara A, Itoh N.
Related Articles, Links
Fgf21 is essential for haematopoiesis in zebrafish.
EMBO Rep. 2006 Jun;7(6):649-54. Epub 2006 Apr 13.
PMID: 16612391 [PubMed - indexed for MEDLINE]
11:
Craik D.
Related Articles, Links
Peptides and therapeutic proteins--SRI conference. New opportunities for macromolecule development, delivery and commercialization. 17-18 November 2005, Philadelphia, PA, USA.
IDrugs. 2006 Jan;9(1):25-7. No abstract available.
PMID: 16374728 [PubMed - indexed for MEDLINE]
12:
Eisenstein M.
Related Articles, Links
Growth factor discovery promises advance in diabetes research.
Lab Anim (NY). 2005 Jun;34(6):10. No abstract available.
PMID: 15924117 [PubMed - indexed for MEDLINE]
13:
Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA, Gromada J, Brozinick JT, Hawkins ED, Wroblewski VJ, Li DS, Mehrbod F, Jaskunas SR, Shanafelt AB.
Related Articles, Links
FGF-21 as a novel metabolic regulator.
J Clin Invest. 2005 Jun;115(6):1627-35. Epub 2005 May 2.
PMID: 15902306 [PubMed - indexed for MEDLINE]
14:
Yamashita T, Yoshioka M, Itoh N.
Related Articles, Links
Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain.
Biochem Biophys Res Commun. 2000 Oct 22;277(2):494-8.
PMID: 11032749 [PubMed - indexed for MEDLINE]
15:
Nishimura T, Nakatake Y, Konishi M, Itoh N.
Related Articles, Links
Identification of a novel FGF, FGF-21, preferentially expressed in the liver.
Biochim Biophys Acta. 2000 Jun 21;1492(1):203-6.
PMID: 10858549 [PubMed - indexed for MEDLINE]