Re: cancer & lifespan
Very interesting, studies and medical references disprove the cancer theory of HGH, that HGH causes cancer or may increase the risks of cancer. Furthermore, studies show that low GH levels may be associated with shortened lifespan. The Mortality rate nearly doubles: 1.82 and in another study the Mortality rate more than doubled at: 2.17 X
Studies Below Show Increased Risk of Cancer Associated with Lower GH and/or IGF-1 levels
Woodson K, Tangrea JA, Pollak M, Copeland TD, Taylor PR, Virtamo J, Albanes D. Serum IGF•1: tumor marker or etiologic factor? A prospective study of prostate cancer among Finnish men. Cancer Res. 2003 JuI15;63(14):3991-4
Baffa R, Reiss K, EI-Gabry EA, Sedor J, Moy ML, Shupp-Byrne D, Strup SE, Hauck WW, Baserga R, Gomella LG. Low serum insulin-like growth factor 1 (IGF-1): a significant association with prostate cancer. Tech Urol. 2000 Sep;6(3):236-9
Chokkalingam AP, Pollak M, Fillmore CM, Gao YT, Stanczyk FZ, Deng J, Sesterhenn lA, Mostofi FK, Fears TR, Madigan MP, Ziegler RG, Fraumeni JF Jr, Hsing AW. Insulin-like growth factors and prostate cancer: a population-based case-control study in China. Cancer Epidemiol Biomarkers Prev 2001 May;10(5):421-7
Colombo F, lannotta F, Fachinetti A, Giuliani F, Cornaggia M, Finzi G, Mantero G, Fraschini F, Malesci A, Bersani M, et al. Changes in hormonal and biochemical parameters in gastric adenocarcinoma. Minerva Endocrinol. 1991 Jul-Sep;16(3):127-39
Low growth hormone may be associated with shorter lifespan:
Studies Below Show Shorter Life Expectancy Associated with Lower GH and/or IGF-1 levels
Rosen T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet. 1990 Aug 4;336(8710):285-8 mortality rate nearly doubles: 1.82
Besson A, Salemi S, Gallati S, Jenal A, Horn R, Mullis PS, Mullis PE. Reduced longevity in untreated patients with isolated growth hormone deficiency. J Clin Endocrinol Metab. 2003 Aug;88(8):3664-7
Bates AS, Van't Hoff W, Jones PJ , Clayton RN. The effect of hypopituitarism on life expectancy. J Clin Endocrinol Metab. 1996;81(3):1169-72
Bulow B, Hagmar L, Mikoczy Z, Nordstrom CH, Erfurth EM. Increased cerebrovascular mortality in patients with hypopituitarism. Clin Endocrinol (Oxf). 1997 Jan;46(1):75-81 Mortality rate doubles: 2.17 X with lower growth hormone
Svensson J, Bengtsson BA, Rosen T, Oden A, Johannsson G. Malignant disease and cardiovascular morbidity in hypopituitary adults with or without growth hormone replacement therapy. J Clin Endocrinol Metab. 2004 Jul;89(7):3306-12
Bengtsson BA, Koppeschaar HP, Abs R, Bennmarker H, Hernberg-Stahl E, Westberg B, Wilton P, Monson JP, Feldt-Rasmussen U, Wuster C. Growth hormone replacement therapy is not associated with any increase in mortality. KIMS Study Group. J Clin Endocrinol Metab. 1999 Nov;84(11):4291•2
Nilsson B, Gustavasson-Kadaka E, Bengtsson BA, Jonsson B. Pituitary adenomas in Sweden between 1958 and 1991: incidence, survival, and mortality. J Clin Endocrinol Metab. 2000;85:14201425. Mortality rate doubles: 2.02 with lower HGH levels
Tomlinson JW, Holden N, Hills RK, et al (West Midlands Prospective Hypopituitary Study Group). Association between premature mortality and hypopituitarism. Lancet. 2001 ;357:425-431 Mortality rate nearly doubles: 1.87 X with lower HGH levels
Roubenoff R, Parise H, Payette HA, Abad LW, D'Agostino R, Jacques PF, Wilson PW, Dinarello CA, Harris TB. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community dwelling men and women: the Framingham Heart Study. Am J Med. 2003 Oct 15; 115(6):429-35.
Denti L, Annoni V, Cattadori E, Salvagnini MA, Visioli S, Merli MF, Corradi F, Ceresini G, Valenti G, Hoffman AR, Ceda GP. Insulin-like growth factor 1 as a predictor of ischemic stroke outcome in the elderly. Am J Med. 2004 Sep 1;117(5):312-7.
Jankowska EA, Biel B, Majda J, Szklarska A, Lopuszanska M, Medras M, Anker SD, Banasiak W, Poole-Wilson PA, Ponikowski P. Anabolic deficiency in men with chronic heart failure: prevalence and detrimental impact on survival. Circulation. 2006 Oct 24; 114(17): 1829-37.
Fernandez-Reyes MJ, Alvarez-Ude F, Sanchez R, Mon C, Iglesias P, Diez JJ, Vazquez A. Inflammation and malnutrition as predictors of mortality in patients on hemodialysis. J Nephrol. 2002 Mar-Apr; 15(2): 136-43.
Petretta M, Colao A, Sardu C, Scopacasa F, Marzullo P, Pivonello R, Fontanella L, de Caterina M, de Simone A, Bonaduce D. NT-proBNP, IGF-I and survival in patients with chronic heart failure. Growth Horm IGF Res. 2007 Aug;17(4):288-96
Rasmuson T, Grankvist K, Jacobsen J, Olsson T, Ljungberg B. Serum insulin-like growth factor-1 is an independent predictor of prognosis in patients with renal cell carcinoma. Acta Oncol. 2004;43(8):744-8.