.gif "IP Gear")
- Joined
- May 19, 2004
- Messages
- 485
I got this from another site just wanted to share
IGF-1 Long R3
1. IGF stands for insulin-like growth factor. It is a
natural substance that is produced in the human body
and is at its highest natural levels during puberty.
During puberty IGF is the most responsible for the
natural muscle growth that occurs during these few
years. There are many different things that IGF does
in the human body; I will only mention the points that
would be important for physical enhancement. Among the
effects the most positive are increased amino acid
transport to cells, increased glucose transport,
increased protein synthesis, decreased protein
degradation, and increased RNA synthesis.
When IGF is active it behaves differently in different
types of tissues. In muscle cells proteins and
associated cell components are stimulated. Protein
synthesis is increased along with amino acid
absorption. As a source of energy, IGF mobilizes fat
for use as energy in adipose tissue. In lean tissue,
IGF prevents insulin from transporting glucose across
cell membranes. As a result the cells have to switch
to burning off fat as a source of energy.
IGF also mimic's insulin in the human body. It makes
muscles more sensitive to insulin's effects, so if you
are a person that currently uses insulin you can lower
your dosage by a decent margin to achieve the same
effects, and as mentioned IGF will keep the insulin
from making you fat.
Perhaps the most interesting and potent effect IGF has
on the human body is its ability to cause hyperplasia,
which is an actual splitting of cells. Hypertrophy is
what occurs during weight training and steroid use, it
is simply an increase in the size of muscle cells.
See, after puberty you have a set number of muscle
cells, and all you are able to do is increase the size
of these muscle cells, you don't actually gain more.
But, with IGF use you are able to cause this
hyperplasia which actually increases the number of
muscle cells present in the tissue, and through weight
training and steroid usage you are able to mature
these new cells, in other words make them grow and
become stronger. So in a way IGF can actually change
your genetic capabilities in terms of muscle tissue
and cell count. IGF proliferates and differentiates
the number of types of cells present. At a genetic
level it has the potential to alter an individuals
capacity to build superior muscle density and size.
There is a lot of talk about the similarity between
IGF and growth hormone. The most often asked question
is simply which is more effective. GH doesn't directly
cause your muscles to grow, it works very indirectly
by increasing protein synthesis capabilities,
increasing the amount of insulin a person can use
effectively, and increasing the amount of anabolic
steroids a person can use effectively. GH also
indirectly causes muscle growth by stimulating the
release of IGF when it (the GH) is destroyed in the
human body. So one way you could look at it as GH
being a precursor to IGF. So to put it simple IGF is
more effective at directly causing muscle growth and
density increases. IGF is also much more cost
effective.
IGF can also be effectively used by itself and gains
will still be easily noticeable. With growth hormone
you need to use high amounts of anabolics and often
insulin to see any gains at all, this is not the case
with IGF. IGF can be used by itself and is often used
by bodybuilders who bridge between cycles, during this
bridge is a good time to use IGF since it has no
effect on natural testosterone production so it will
therefore allow you to return to normal in terms of
hormone levels. A stack of IGF, PGF2a, HCG, and clomid
would be a good bridge stack and would allow your body
to return to normal and still allow you to retain and
make new gains.
IGF is a research drug, it hasn't been approved by the
FDA for use as a pharmaceutical and it is currently
being researched for nerve tissue repair, possible
burn victims, and also as a possible aid in muscle
wasting for AIDS patients. There are many different
analogs of IGF available, instead of mentioning them
all, I will simply mention the two most common and the
most effective. Regular recombinant IGF is one of the
two, it is also the more expensive and the least
effective. Regular IGF only has a half-life of about
10-20 minutes in the human body and is quickly
destroyed, it can be combined with certain binding
proteins to extend the half-life, but it is not a very
simple procedure and there is a more effective and
less expensive version available. The most effective
form of IGF is Long R3 IGF-1, it has been chemically
altered and has had amino acid changes which cause it
to avoid binding to proteins in the human body and
allow it to have a much longer half life, around 20-30
hours. "Long R3 IGF-1 is an 83 amino acid analog of
IGF-1 comprising the complete human IGF-1 sequence
with the substition of an Arg® for the Glu(E) at
position three, hence R3, and a 13 amino acid
extension peptide at the N terminus. This analog of
IGF-1 has been produced with the purpose of increasing
the biological activity of the IGF peptide."
"Long R3 IGF-1 is signifacantly more potent than
IGF-1. The enhanced potency is due to the decreased
binding of Long R3 IGF-1 to all known IGF binding
proteins. These binding proteins normally inhibit the biological actions of IGF's."
It is also not as expensive since a media grade
version is available which is sufficient for
bodybuilding use. There is also a receptor grade
available but it is VERY expensive and the only
noticeable difference between the two would only be
able to be noticed in a laboratory setting. The price
on the black market for Long R3 IGF-1 can be seen
anywhere from $300-$500 per milligram depending on the
source, be wary of black market dealers of any IGF
since it is a VERY difficult item to obtain. As
mentioned IGF is a research product and is only
available from a few laboratories in the world and is
only available to research companies and biotechnology institutions. For the rest of this article when I say IGF I am now referring to Long R3 IGF-1 for simplicity sake.
Any form of IGF is ONLY supplied in a lyphosized form,
which means a dry powder state. NEVER PUCHASE
PRE-DILUTED LIQUID IGF!!!! There is no such product
made anywhere in the world and even if there were real
IGF ever present in the vial it would all be dead by
the time you receive it. IGF is a very delicate
peptide and must be diluted by yourself, where you
have access to a refrigerator and freezer. There has
also been a lot of talk by certain sources claiming to
have IGF made by the Eli Lilly company, to clear
things up Lilly is a pharmaceutical company and as
stated IGF is a research drug and has not yet been
approved, Lilly does not and never has manufactured
research drugs for retail sale.
The dilutents you will need for the IGF are a weak concentration of hydrochloric acid and a sterile buffer(sterile water or bacteriostatic water) the procedure for diluting the IGF is not very difficult, the dilutents can be obtained from most local chemical suppliers and a good source of IGF would also be able to supply the necessary dilutents.
The most effective length for a cycle of IGF is 50
days on and 20-40 days off. The most controversy
surrounding Long R3 IGF-1 is the effective dosage. The
most used dosages range between 20mcg/day to
120+mcg/day. IGF is only available by the milligram,
one mg will give you a 50 day cycle at 20mcg/day, 2mg
will give you a 50 day cycle at 40mcg/day, 3mg will
give you a 50 day cycle at 60mcg/day, 4mg will give
you a 50 day cycle at 80mcg/day and so on. The dosage
issue mainly revolves around how much money you have
to spend, plenty of people use the minimum dosage of
20mcg/day and are happy with the results, and in fact
several top bodybuilders use the 20mcg/day dosage and
are pleased with the results. IGF is most effective
when administered subcutaneously and injected once or
twice daily at your current dosage. The best time for injections is either in the morning and/or immediately after weight training.
Another frequently asked question of IGF refers to the
real world results, in terms of pure weight gain don't
expect to gain 5 lbs. a week like you may off of
anadrol or a similar steroid. The only weight you will
gain from IGF use is pure lean muscle tissue, with
steroids most of the weight gained is water weight.
With an effective dosage you can expect to gain 1-2
lbs of new lean muscle tissue every 2-3 weeks and
these effects can be increased with the use of
testosterone, anabolic steroids, and insulin use.
Increased vascularity is also very common, people
report seeing veins appear where they never have
before. And yet another effect reported is the ability
to stay lean while bulking with heavy dosages of
steroids and TONS of food while on an IGF cycle, this
is perhaps the most pleasing effect. Increased pumps
are also noticeable almost immediately, the pumps can
almost become painful, pumps are even noticeable when
doing cardio.
Overall, IGF is a very exciting drug due to its
ability to alter ones genetic capabilities. If you can
find a trustworthy source and you use it correctly it
can be a VERY useful tool in your bodybuilding drug arsenal.
IGF-1 Long R3
1. IGF stands for insulin-like growth factor. It is a
natural substance that is produced in the human body
and is at its highest natural levels during puberty.
During puberty IGF is the most responsible for the
natural muscle growth that occurs during these few
years. There are many different things that IGF does
in the human body; I will only mention the points that
would be important for physical enhancement. Among the
effects the most positive are increased amino acid
transport to cells, increased glucose transport,
increased protein synthesis, decreased protein
degradation, and increased RNA synthesis.
When IGF is active it behaves differently in different
types of tissues. In muscle cells proteins and
associated cell components are stimulated. Protein
synthesis is increased along with amino acid
absorption. As a source of energy, IGF mobilizes fat
for use as energy in adipose tissue. In lean tissue,
IGF prevents insulin from transporting glucose across
cell membranes. As a result the cells have to switch
to burning off fat as a source of energy.
IGF also mimic's insulin in the human body. It makes
muscles more sensitive to insulin's effects, so if you
are a person that currently uses insulin you can lower
your dosage by a decent margin to achieve the same
effects, and as mentioned IGF will keep the insulin
from making you fat.
Perhaps the most interesting and potent effect IGF has
on the human body is its ability to cause hyperplasia,
which is an actual splitting of cells. Hypertrophy is
what occurs during weight training and steroid use, it
is simply an increase in the size of muscle cells.
See, after puberty you have a set number of muscle
cells, and all you are able to do is increase the size
of these muscle cells, you don't actually gain more.
But, with IGF use you are able to cause this
hyperplasia which actually increases the number of
muscle cells present in the tissue, and through weight
training and steroid usage you are able to mature
these new cells, in other words make them grow and
become stronger. So in a way IGF can actually change
your genetic capabilities in terms of muscle tissue
and cell count. IGF proliferates and differentiates
the number of types of cells present. At a genetic
level it has the potential to alter an individuals
capacity to build superior muscle density and size.
There is a lot of talk about the similarity between
IGF and growth hormone. The most often asked question
is simply which is more effective. GH doesn't directly
cause your muscles to grow, it works very indirectly
by increasing protein synthesis capabilities,
increasing the amount of insulin a person can use
effectively, and increasing the amount of anabolic
steroids a person can use effectively. GH also
indirectly causes muscle growth by stimulating the
release of IGF when it (the GH) is destroyed in the
human body. So one way you could look at it as GH
being a precursor to IGF. So to put it simple IGF is
more effective at directly causing muscle growth and
density increases. IGF is also much more cost
effective.
IGF can also be effectively used by itself and gains
will still be easily noticeable. With growth hormone
you need to use high amounts of anabolics and often
insulin to see any gains at all, this is not the case
with IGF. IGF can be used by itself and is often used
by bodybuilders who bridge between cycles, during this
bridge is a good time to use IGF since it has no
effect on natural testosterone production so it will
therefore allow you to return to normal in terms of
hormone levels. A stack of IGF, PGF2a, HCG, and clomid
would be a good bridge stack and would allow your body
to return to normal and still allow you to retain and
make new gains.
IGF is a research drug, it hasn't been approved by the
FDA for use as a pharmaceutical and it is currently
being researched for nerve tissue repair, possible
burn victims, and also as a possible aid in muscle
wasting for AIDS patients. There are many different
analogs of IGF available, instead of mentioning them
all, I will simply mention the two most common and the
most effective. Regular recombinant IGF is one of the
two, it is also the more expensive and the least
effective. Regular IGF only has a half-life of about
10-20 minutes in the human body and is quickly
destroyed, it can be combined with certain binding
proteins to extend the half-life, but it is not a very
simple procedure and there is a more effective and
less expensive version available. The most effective
form of IGF is Long R3 IGF-1, it has been chemically
altered and has had amino acid changes which cause it
to avoid binding to proteins in the human body and
allow it to have a much longer half life, around 20-30
hours. "Long R3 IGF-1 is an 83 amino acid analog of
IGF-1 comprising the complete human IGF-1 sequence
with the substition of an Arg® for the Glu(E) at
position three, hence R3, and a 13 amino acid
extension peptide at the N terminus. This analog of
IGF-1 has been produced with the purpose of increasing
the biological activity of the IGF peptide."
"Long R3 IGF-1 is signifacantly more potent than
IGF-1. The enhanced potency is due to the decreased
binding of Long R3 IGF-1 to all known IGF binding
proteins. These binding proteins normally inhibit the biological actions of IGF's."
It is also not as expensive since a media grade
version is available which is sufficient for
bodybuilding use. There is also a receptor grade
available but it is VERY expensive and the only
noticeable difference between the two would only be
able to be noticed in a laboratory setting. The price
on the black market for Long R3 IGF-1 can be seen
anywhere from $300-$500 per milligram depending on the
source, be wary of black market dealers of any IGF
since it is a VERY difficult item to obtain. As
mentioned IGF is a research product and is only
available from a few laboratories in the world and is
only available to research companies and biotechnology institutions. For the rest of this article when I say IGF I am now referring to Long R3 IGF-1 for simplicity sake.
Any form of IGF is ONLY supplied in a lyphosized form,
which means a dry powder state. NEVER PUCHASE
PRE-DILUTED LIQUID IGF!!!! There is no such product
made anywhere in the world and even if there were real
IGF ever present in the vial it would all be dead by
the time you receive it. IGF is a very delicate
peptide and must be diluted by yourself, where you
have access to a refrigerator and freezer. There has
also been a lot of talk by certain sources claiming to
have IGF made by the Eli Lilly company, to clear
things up Lilly is a pharmaceutical company and as
stated IGF is a research drug and has not yet been
approved, Lilly does not and never has manufactured
research drugs for retail sale.
The dilutents you will need for the IGF are a weak concentration of hydrochloric acid and a sterile buffer(sterile water or bacteriostatic water) the procedure for diluting the IGF is not very difficult, the dilutents can be obtained from most local chemical suppliers and a good source of IGF would also be able to supply the necessary dilutents.
The most effective length for a cycle of IGF is 50
days on and 20-40 days off. The most controversy
surrounding Long R3 IGF-1 is the effective dosage. The
most used dosages range between 20mcg/day to
120+mcg/day. IGF is only available by the milligram,
one mg will give you a 50 day cycle at 20mcg/day, 2mg
will give you a 50 day cycle at 40mcg/day, 3mg will
give you a 50 day cycle at 60mcg/day, 4mg will give
you a 50 day cycle at 80mcg/day and so on. The dosage
issue mainly revolves around how much money you have
to spend, plenty of people use the minimum dosage of
20mcg/day and are happy with the results, and in fact
several top bodybuilders use the 20mcg/day dosage and
are pleased with the results. IGF is most effective
when administered subcutaneously and injected once or
twice daily at your current dosage. The best time for injections is either in the morning and/or immediately after weight training.
Another frequently asked question of IGF refers to the
real world results, in terms of pure weight gain don't
expect to gain 5 lbs. a week like you may off of
anadrol or a similar steroid. The only weight you will
gain from IGF use is pure lean muscle tissue, with
steroids most of the weight gained is water weight.
With an effective dosage you can expect to gain 1-2
lbs of new lean muscle tissue every 2-3 weeks and
these effects can be increased with the use of
testosterone, anabolic steroids, and insulin use.
Increased vascularity is also very common, people
report seeing veins appear where they never have
before. And yet another effect reported is the ability
to stay lean while bulking with heavy dosages of
steroids and TONS of food while on an IGF cycle, this
is perhaps the most pleasing effect. Increased pumps
are also noticeable almost immediately, the pumps can
almost become painful, pumps are even noticeable when
doing cardio.
Overall, IGF is a very exciting drug due to its
ability to alter ones genetic capabilities. If you can
find a trustworthy source and you use it correctly it
can be a VERY useful tool in your bodybuilding drug arsenal.
