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Here is some info I have gathered from various sources. I hope to see some logs of this combo at high doses soon!
(From Wikipedia)
In 2008, researchers at the Salk Institute discovered that AICAR given to experimental mice significantly improves their performance in endurance-type exercise, apparently by converting fast-twitch muscle fibers to the more energy-efficient, fat-burning, slow-twitch type. They also looked at the administration of GW 501516 (also called GW1516) in combination with AICAR. Given to mice that did not exercise, this combination activated 40% of the genes that were turned on when mice were given GW1516 and made to exercise. This suggests it may be possible to obtain some of the benefits of exercising without actually exercising.[4] Because of the enhanced endurance effects, this could potentially be used by athletes to enhance their performance. One of the lead researchers from this study has developed a urine test to detect it and has made the test available to the International Olympic Committee, and the World Anti-Doping Agency has added AICAR to the prohibited list from 2009 onwards.[5]
(From Emaxhealth.com)
AICAR and GW1516 experiments suggest that these two drugs, also called exercise in a pill, might protect against gaining weight on a high-fat diet, which might make it useful for treating obesity.
Researchers have identified two drugs, AICAR and GW1516, that mimic many of the physiological effects of exercise. The drugs increase the ability of cells to burn fat and are the first compounds that have been shown to enhance exercise endurance.
Both AICAR and GW1516 can be given orally and work by genetically reprogramming muscle fibers so they use energy better and contract repeatedly without fatigue. In laboratory experiments, mice taking the drugs ran faster and longer than normal mice on treadmill tests. Animals that were given AICAR, one of the two drugs, ran 44 percent longer than untreated animals. The second compound, GW1516, had a more dramatic impact on endurance, but only when combined with exercise.
the scientists subjected two groups of mice — one that received the drug and one that did not — to interval training. The mice ran for 30 minutes on a slow treadmill five days a week for a total of four weeks. At the end of the training period, all of the mice - regardless of whether they had received GW1516 - had improved their performance. Those that had received GW1516, however, ran 68 percent longer than those that had only done the exercise training. “The dramatic effect of the drug was stunning,” Evans said.
“This is a drug that is like pharmacological exercise,” Evans says. “After four weeks of receiving the drug, the mice were behaving as if they'd been exercised.” In fact, he says, those that got the drug actually ran longer and further than animals that received exercise training.
The animals receiving AICAR improved their running performance and their ability to burn fat. None of these effects, however, were as strong as they were in the animals that received both exercise and activation of PPAR-delta via GW1516.
Like exercise, AICAR and GW1516 trigger a variety of changes that contribute to muscles cells' improved endurance and ability to burn fat. These changes include an increase in mitochondria, the structures responsible for producing energy; a shift in metabolism that takes advantage of lipids as an energy source; and an increase in blood flow, which enables the steady delivery of fat to burn. While the scientists only examined the drugs' effects on muscle cells in this study, Evans says it is likely that they confer benefits on other systems impacted by exercise, such as the heart and lungs.
Evans expects these types of drugs will be attractive to a variety of individuals. “If you like exercise, you like the idea of getting more bang for your buck,” he says of GW1516. “If you don't like exercise, you love the idea of getting the benefits from a pill,” as with AICAR.
So, while Evans sees tremendous opportunities for health benefits from drugs that mimic exercise, he also sees serious potential for abuse.
“Drugs that improve health are not only going to be used by people who have medical problems. They may also be used by people who are healthy - or by athletes who want an edge,” said Evans. He noted that the sports world has long been aware of his lab's work demonstrating a link between PPAR-delta and endurance. What's more, GW1516 has a relatively simple chemical structure and can be synthesized easily. Evans anticipates that athletes will seek their own sources of the drug - if they haven't already.
(From iSteroids.com)
The revolutionary AICAR and GW1516 are the newest buddies of athletes, and anti-doping authorities are scrambling to screen for these exercise-in-a-pill compounds. There are so called because they imitate the physiological effect of exercise in the body.
These drugs are welcome news for individuals who suffer obesity, metabolic disorders, and muscular dystrophy. These oral compounds work by “genetically reprogramming muscle fibers so they use energy better and contract repeatedly without fatigue.” This means that those who use AICAR and GW1516 need not do actual exercise and yet could shed unwanted fat. No wonder these two are now touted as miracle pills.
(From youtube.com)
YouTube - Too Good to be True??
YouTube - Exercise In A Pill
(From WebMD.com)
It may be possible to make a pill that captures the endurance-boosting effects of exercise, scientists report in Cell.
So far, they've tested two compounds in lab tests in mice. One of those compounds, called GW1516, boosted endurance in mice that exercised, but not in sedentary mice. The other compound, called AICAR, improved endurance in mice that didn't exercise at all.
Evans' team then worked on getting the same result without genetic engineering. They squirted GW1516, which boosts PPAR-delta, into mice's mouths every day for a month.
At the end of the month, the mice ran 68% longer and 70% farther than when the experiment began -- but only if they had been running on exercise wheels daily while taking the drug. GW1516 didn't do anything for mice that weren't exercising.
Next, the scientists focused on another protein called AMPK. They gave sedentary mice a daily injection of AICAR, which boosts AMPK, for a month.
At the end of the month, those mice ran 23% longer and 44% farther than before starting AICAR treatment. That is, their endurance had improved without working out.
The results show that AMPK and PPAR-delta "can be targeted by orally active drugs to enhance training or even to increase endurance without exercise," write the researchers.
(From aicar.co.uk)
AICAR is toally effective at changing “fast twitching” muscle to “slow twitching” muscle. This effect of AICAR is only possible usually by the sort of intense training undertaken by long distance runners or keen swimmers.
Why should you want the befit of AICAR? Its simple – slow twitching muscle burns fat, fast twitching burns sugars. Finally you have a way or targeting the way your body burns its fat reserves without dieting which of course just puts your body into starvation mode making it horde fat reserves.
AICAR is not readily avaliable but if you can find it – get some while you can!
(From Professionalmuscle.com)
I believe 2-5 mg/kg daily is the correct dosage. However I have heard that tests have been done at 10mg ED, so as a first time researcher of said compound, I will start at 10mg daily and work up to 1-2mg/kg body weight daily.
As far as side effects go, I have not found any as of yet except in large doses you may find, as in any fat burning agent, high BP, and possibly heart palpitations. So caution is the word for me when research is so new and hard to come by.
I hope this helps anybody curious about GW 1516 and its benefits. I also caution that I am in now way shape or form a professional. Please do your own research before solely trusting mine.
(Articles From websites)
**broken link removed**
Couch-Potato Drugs Are WADA?s First Banned for Gene-Doping Ties - Bloomberg.com
**broken link removed**
**broken link removed**
(From Wikipedia)
In 2008, researchers at the Salk Institute discovered that AICAR given to experimental mice significantly improves their performance in endurance-type exercise, apparently by converting fast-twitch muscle fibers to the more energy-efficient, fat-burning, slow-twitch type. They also looked at the administration of GW 501516 (also called GW1516) in combination with AICAR. Given to mice that did not exercise, this combination activated 40% of the genes that were turned on when mice were given GW1516 and made to exercise. This suggests it may be possible to obtain some of the benefits of exercising without actually exercising.[4] Because of the enhanced endurance effects, this could potentially be used by athletes to enhance their performance. One of the lead researchers from this study has developed a urine test to detect it and has made the test available to the International Olympic Committee, and the World Anti-Doping Agency has added AICAR to the prohibited list from 2009 onwards.[5]
(From Emaxhealth.com)
AICAR and GW1516 experiments suggest that these two drugs, also called exercise in a pill, might protect against gaining weight on a high-fat diet, which might make it useful for treating obesity.
Researchers have identified two drugs, AICAR and GW1516, that mimic many of the physiological effects of exercise. The drugs increase the ability of cells to burn fat and are the first compounds that have been shown to enhance exercise endurance.
Both AICAR and GW1516 can be given orally and work by genetically reprogramming muscle fibers so they use energy better and contract repeatedly without fatigue. In laboratory experiments, mice taking the drugs ran faster and longer than normal mice on treadmill tests. Animals that were given AICAR, one of the two drugs, ran 44 percent longer than untreated animals. The second compound, GW1516, had a more dramatic impact on endurance, but only when combined with exercise.
the scientists subjected two groups of mice — one that received the drug and one that did not — to interval training. The mice ran for 30 minutes on a slow treadmill five days a week for a total of four weeks. At the end of the training period, all of the mice - regardless of whether they had received GW1516 - had improved their performance. Those that had received GW1516, however, ran 68 percent longer than those that had only done the exercise training. “The dramatic effect of the drug was stunning,” Evans said.
“This is a drug that is like pharmacological exercise,” Evans says. “After four weeks of receiving the drug, the mice were behaving as if they'd been exercised.” In fact, he says, those that got the drug actually ran longer and further than animals that received exercise training.
The animals receiving AICAR improved their running performance and their ability to burn fat. None of these effects, however, were as strong as they were in the animals that received both exercise and activation of PPAR-delta via GW1516.
Like exercise, AICAR and GW1516 trigger a variety of changes that contribute to muscles cells' improved endurance and ability to burn fat. These changes include an increase in mitochondria, the structures responsible for producing energy; a shift in metabolism that takes advantage of lipids as an energy source; and an increase in blood flow, which enables the steady delivery of fat to burn. While the scientists only examined the drugs' effects on muscle cells in this study, Evans says it is likely that they confer benefits on other systems impacted by exercise, such as the heart and lungs.
Evans expects these types of drugs will be attractive to a variety of individuals. “If you like exercise, you like the idea of getting more bang for your buck,” he says of GW1516. “If you don't like exercise, you love the idea of getting the benefits from a pill,” as with AICAR.
So, while Evans sees tremendous opportunities for health benefits from drugs that mimic exercise, he also sees serious potential for abuse.
“Drugs that improve health are not only going to be used by people who have medical problems. They may also be used by people who are healthy - or by athletes who want an edge,” said Evans. He noted that the sports world has long been aware of his lab's work demonstrating a link between PPAR-delta and endurance. What's more, GW1516 has a relatively simple chemical structure and can be synthesized easily. Evans anticipates that athletes will seek their own sources of the drug - if they haven't already.
(From iSteroids.com)
The revolutionary AICAR and GW1516 are the newest buddies of athletes, and anti-doping authorities are scrambling to screen for these exercise-in-a-pill compounds. There are so called because they imitate the physiological effect of exercise in the body.
These drugs are welcome news for individuals who suffer obesity, metabolic disorders, and muscular dystrophy. These oral compounds work by “genetically reprogramming muscle fibers so they use energy better and contract repeatedly without fatigue.” This means that those who use AICAR and GW1516 need not do actual exercise and yet could shed unwanted fat. No wonder these two are now touted as miracle pills.
(From youtube.com)
YouTube - Too Good to be True??
YouTube - Exercise In A Pill
(From WebMD.com)
It may be possible to make a pill that captures the endurance-boosting effects of exercise, scientists report in Cell.
So far, they've tested two compounds in lab tests in mice. One of those compounds, called GW1516, boosted endurance in mice that exercised, but not in sedentary mice. The other compound, called AICAR, improved endurance in mice that didn't exercise at all.
Evans' team then worked on getting the same result without genetic engineering. They squirted GW1516, which boosts PPAR-delta, into mice's mouths every day for a month.
At the end of the month, the mice ran 68% longer and 70% farther than when the experiment began -- but only if they had been running on exercise wheels daily while taking the drug. GW1516 didn't do anything for mice that weren't exercising.
Next, the scientists focused on another protein called AMPK. They gave sedentary mice a daily injection of AICAR, which boosts AMPK, for a month.
At the end of the month, those mice ran 23% longer and 44% farther than before starting AICAR treatment. That is, their endurance had improved without working out.
The results show that AMPK and PPAR-delta "can be targeted by orally active drugs to enhance training or even to increase endurance without exercise," write the researchers.
(From aicar.co.uk)
AICAR is toally effective at changing “fast twitching” muscle to “slow twitching” muscle. This effect of AICAR is only possible usually by the sort of intense training undertaken by long distance runners or keen swimmers.
Why should you want the befit of AICAR? Its simple – slow twitching muscle burns fat, fast twitching burns sugars. Finally you have a way or targeting the way your body burns its fat reserves without dieting which of course just puts your body into starvation mode making it horde fat reserves.
AICAR is not readily avaliable but if you can find it – get some while you can!
(From Professionalmuscle.com)
I believe 2-5 mg/kg daily is the correct dosage. However I have heard that tests have been done at 10mg ED, so as a first time researcher of said compound, I will start at 10mg daily and work up to 1-2mg/kg body weight daily.
As far as side effects go, I have not found any as of yet except in large doses you may find, as in any fat burning agent, high BP, and possibly heart palpitations. So caution is the word for me when research is so new and hard to come by.
I hope this helps anybody curious about GW 1516 and its benefits. I also caution that I am in now way shape or form a professional. Please do your own research before solely trusting mine.
(Articles From websites)
**broken link removed**
Couch-Potato Drugs Are WADA?s First Banned for Gene-Doping Ties - Bloomberg.com
**broken link removed**
**broken link removed**
