HGH Administration (split the doses or not)

TooPowerful4u · Nov 11, 2004

On another board (elitefitness) there are posts saying regardless of how much HGH you do, it is best to keep any single dose to 2IU or less more than that may be wasted. They're recommending the second dose should be about 6-8 hours later

THIS WAS WRITTEN BY A FRIEND OF MINE. HES A MEMBER OF ELITE AND ASKED ME TO POST THE QUESTION HERE IN HOPES YOU GUYS COULD SHED SOME LIGHT ON THIS

mike ross · Nov 11, 2004

makes no sense. we dose kids according to their bodyweight in kg with the total dose per day in one morning injection...they grow just fine.

Dad · Nov 11, 2004

One thing to consider

People have done the one dose, or multi dose approach, and gotten results.

One of the reasons for splitting the dose is the way GH works in the body. GH has a short half-life. It promotes IGF-1 production in the liver, and IGF-1 has a VERY short half-life. By splitting the dose, you may be sort of re-applying this mechanism several times daily.

Is 2 IU the magic number? Not sure if there's any reason to think more wouldn't be ok, as people use more than that in the single dose approach, Either way, the half-lives and mechanism are the same.

mike ross · Nov 11, 2004

honestly people are making this much more complicated than it has to be.

Wallace · Nov 11, 2004

Short children get a evening injection, if they get one inj per day. I read a study some time ago which said that splitting the total dose in 2/3 evening 1/3 morning gave better results.

IMO splitting too much is counterproductive and would give more gh-belly than muscle-tendon anabolism ... this on the basis of some studies with IGF1 ... when infused continously 24h/day the effect was more pronounced on intestine than muscle ... the opposite when the same 24h dose was splittet in 2 boluses every 12 hours ...

GH prompts a IGF1 response which lasts about 24 hours for the first weeks, then gradually drops to 6-8 hours AT MOST (at 6 weeks at least).

One issue that I never understand is the advice of injecting g far from the time of the day when a natural g peak occurs ... when u are on g you do not have natural g peaks because the IGF1 shuts the axis down, exactly as aas do with the gonadal axis ... I personally think it would be better to try mimic the natural production and so inject exactly following the natural rythme, not the opposite ....

injecting at bed time, for example, give the body the unique opportunity to shift towards fat burning during the nite, with the following anti catabolic effect (which is mostly mediated by the concentration of ffa in plasma) ... which, in turn, allow spleep to be an anticatabolic time despite no food is ingested .... if you use g and avoid injecting at bed time u will have your natural g production very low and therfore no g peak at nite, consequently no g mediated lipolytic anticatabolic effect ....

Just my 2 cents

Wallace

mike ross · Nov 11, 2004

no offense, if you want me to scan the package literature from nutropin or genotropin i will. it clearly states morning injections and thats how we give it at the hospital. not trying to offend you but thats the way the package literature reads and states.

however, i do agree somewhat on everything else you said wallace. good points

PHIL HERNON · Nov 11, 2004

AMEN

mike ross said:
no offense, if you want me to scan the package literature from nutropin or genotropin i will. it clearly states morning injections and thats how we give it at the hospital. not trying to offend you but thats the way the package literature reads and states.

however, i do agree somewhat on everything else you said wallace. good points

Praise the lord. Thank you Mikey, this has been driving me crazy, hahahaahahhha

bigbaldbulldog · Nov 11, 2004

PHIL HERNON said:
Praise the lord. Thank you Mikey, this has been driving me crazy, hahahaahahhha

Who is this Phil guy and does he REALLY know what he is talking about?? LMAO....what i have learned in this sport is the book reality and the street reality are usually 2 different things...everyone is different and therefore will have different results..trail and error...the paper insert may say morning but in the real world it may be different..who knows though..good luck..hi Phil i need to get to the gym and train again i'm slaking with all the hours..

Wallace · Nov 11, 2004

mike ross said:
no offense, if you want me to scan the package literature from nutropin or genotropin i will. it clearly states morning injections and thats how we give it at the hospital. not trying to offend you but thats the way the package literature reads and states.

however, i do agree somewhat on everything else you said wallace. good points

You are certanly right! I have stopped working with growth hormone few years back ... at that time, the usual schedule for short children was to split the weekly dose in 3 injections, tipically ma-we-fr... after a while somebody thought it might be better to divide it in 6 or 7 even doses, and give them at night, to mimic the normal production...

Now I have had a look in Medline and I see that they found no big difference with different timing schedule ...

And I founf also a study which says that the response to GHRH is impaired by gh administration only for a short time ... and that after 24 hours it was restored ... in that case a 3 times a week schedule has probably good chances to not shut down the axis ...

It is pure speculation of course ... the only effect that I had from gh has been carpal tunnel ... never used again ...

Wallace

Wallace · Nov 11, 2004

bigbaldbulldog said:
...what i have learned in this sport is the book reality and the street reality are usually 2 different things...everyone is different and therefore will have different results..trail and error...the paper insert may say morning but in the real world it may be different..who knows though..good luck..hi Phil i need to get to the gym and train again i'm slaking with all the hours..

This is expecially true!

Wallace

Armageddon · Nov 11, 2004

I've found that morning or even during the day makes me pretty sleepy and lathargic and if I take it before bed I have some really vivid and crazy dreams. Actually more like nightmares. Since the first time I took that stuff I see shit when I sleep that actual seems like it comes true.

I don't understand it myself and don't generally tell anyone as it doesn't seem right. It's how I caught one of my last girlfriends cheating on me. I saw it in a dream and confronted her about it and there it was. I kind of got freaked by it and couldn't/can't explain it. She asked how I knew and I said my dream. Needless to say I went back to being lethargic and sleepy as I did want to know certain things I guess

JETHRO TULL · Nov 11, 2004

GET BACK ON IT AND THINK ABOUT THE LOTTERY!

Armageddon said:
I've found that morning or even during the day makes me pretty sleepy and lathargic and if I take it before bed I have some really vivid and crazy dreams. Actually more like nightmares. Since the first time I took that stuff I see shit when I sleep that actual seems like it comes true. I don't understand it myself and don't generally tell anyone as it doesn't seem right. It's how I caught one of my last girlfriends cheating on me. I saw it in a dream and confronted her about it and there it was. I kind of got freaked by it and couldn't/can't explain it. She asked how I knew and I said my dream. Needless to say I went back to being lethargic and sleepy as I did want to know certain things I guess

BUY A TICKET ONCE IN A WHILE....GO ALL OUT!

mike ross · Nov 12, 2004

yeah wallace, everyone was confused when the stuff became available at first, but now the difference is not significant. when i first used the stuff myself i was doing 2iu post workout with 10iu humalog and got real good results considering the dosage

i do agree that each person is different and what works for one will not for another. i have always preached this, ask phil

PHIL HERNON · Nov 12, 2004

Yes he has but.......

mike ross said:
yeah wallace, everyone was confused when the stuff became available at first, but now the difference is not significant. when i first used the stuff myself i was doing 2iu post workout with 10iu humalog and got real good results considering the dosage

i do agree that each person is different and what works for one will not for another. i have always preached this, ask phil

Only for as long as I have known him. I cant say what he was saying before I knew him, I can only speculate.

Big A · Nov 22, 2004

mike ross said:
honestly people are making this much more complicated than it has to be.

Agreed.

I like to take a whole dose in the evening before bed and when I wake up in the morning I can see a difference. And no, it's not placebo, as if you take a whopping dose in the evening, in the morning your body looks more 'quality' and your skin has this glowing effect. It happens on everyone that I've seen with this schedule.
I also like Phil's method of 24IU once every 2 weeks.

Wallace · Nov 22, 2004

Big A said:
I also like Phil's method of 24IU once every 2 weeks.

You mean he takes 24 units in one single dose every 2 weeks?

Wallace

Big A · Nov 22, 2004

Wallace said:
You mean he takes 24 units in one single dose every 2 weeks?

Wallace

Yep. I tried it and I found I like 24IU once a week better.

bigbaldbulldog · Nov 22, 2004

Big A said:
Yep. I tried it and I found I like 24IU once a week better.

You liked taken 24 ius once a week better then...? then 2-4 ius at night time ?...GH is a very expensive experiment...no matter what you do !!

vitor · Nov 22, 2004

Explain

Can you explain alittle further, why would 24iu's once a week or once every 2 weeks be better than ED, do you still get the same sides with this method.

hardkor · Nov 22, 2004

This will an ongoing debate forever!

FYI- Dave Palumbo recommends injecting HGH apon rising from bed and Tom Prince suggest before bed. Looks like it doesn't really matter...just take it!